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Dr. Anastasia Sacharidou

Assistant Professor

University of North Texas

Department of Biological Sciences

(940) 369-7282

Email: Anastasia.Sacharidou@unt.edu

Education

  • PhD, University of Missouri - Columbia, 2010
    Major: Physiology

Professional Memberships

  • American Diabetes Association. (September 2017 - Present).
  • American Heart Association. (September 2007 - Present).
  • North American Vascular Biology Organization. (2007 - Present).

Development Activities

  • Other (Faculty development program), NCFDD Faculty Success Program, self. United States of America. (October 2024).
  • Seminar, BioFrontier - Biology Seminar series (in person LSC-a117), Dept of Biological Sciences, UNT-Denton. Denton,TX,United States of America. (August 23, 2024).
  • Continuing Education Program, ACUE Teaching Certification (Online course), UNT - VPRI's office. Denton,TX,United States of America. (August 2024).
  • Seminar, Earl P. Benditt Award Lecture Dr. Asrar Malik (online), NAVBO. United States of America. (January 14, 2025 - January 14, 2025).
  • Workshop, Fall Faculty Grantsmanship Workshop (in-person), UNT - Denton. Denton,TX,United States of America. (December 10, 2024 - December 10, 2024).
  • Workshop, PVD - How to write a competitive abstract (online), American Heart Association. United States of America. (December 4, 2024 - December 4, 2024).
  • Workshop, NSF BIO/IOS Postdoc to PI webinar (online), NSF (BIO and IOS). United States of America. (November 20, 2024 - November 20, 2024).
  • Other (Mini-symposium), CENG-COS Jr. Faculty Meeting day 2 (in person at SRB), UNT-Denton (VPRI office). Denton,TX,United States of America. (November 19, 2024 - November 19, 2024).
  • Other (Mini-symposium), CENG-COS Jr. Faculty Meeting Day 1 - (in-person at Discovery Park), UNT-Denton (VPRI office). Denton,TX,United States of America. (November 13, 2024 - November 13, 2024).
  • Workshop, Career Developmnet Forum: NIH Study Sections (online career development workshop), NAVBO. United States of America. (November 12, 2024 - November 12, 2024).
  • Other (Mini-symposium), October COS Jr. Research Faculty (in person), UNT - Denton (VPRI office). Daneton,TX,United States of America. (October 28, 2024 - October 28, 2024).
  • Workshop, October Research Café Crafting Effective Specific Aims for NIH Grants (online workshop), HSC-UNT. United States of America. (October 23, 2024 - October 23, 2024).
  • Workshop, IRB Human Subjects Research (online), UNT-Denton. Denton,TX,United States of America. (September 25, 2024 - September 25, 2024).
  • Seminar, Surrounding Tissues on Vessel Function ( online mini-symposium organized by NAVBO), NAVBO. United States of America. (September 12, 2024 - September 12, 2024).

Teaching

Teaching Experience

    University of North Texas

  • BIOL 4110 - Endocrinology, 1 course.
  • BIOL 5110 - Endocrinology., 1 course.

Directed Student Learning

  • Doctoral Advisory Committee Member, "Regulation of Von Willebrand Factor (VWF) Levels," Biological Sciences. (December 2024).
  • Master's Thesis Committee Member, "Investigating genes affecting membrane trafficking proteins, using zebrafish as a model organism," Biological Sciences. (November 2024).
  • Supervised Research, "Endothelial Cell Genes Contributing to the Development of Thrombosis," Biological Sciences. (November 2024).
  • Postdoctoral Research Supervision, "Identify novel regulatory proteins involved in thrombosis," Biological Sciences. (August 2024).

Awards and Honors

  • ATVB Junior Investigator Award for Women, ATVB/PVD. (May 6, 2016).
  • Outstanding poster presentation, NAVBO/ Developmental Vascular Biology. (2010).
  • Outstanding Poster Presentation, NAVBO/ Integrin Signaling in Physiology and Disease. (2010).
  • Outstanding Abstract and Poster Presentation, University of Missouri/ Dept of Medical Pharmacology and Physiology. (2009).
  • Outstanding Poster Presentation, NAVBO/ Developmental Vascular Biology. (2008).
  • Outstanding Abstract and Poster Presentation, Texas A&M University/ Texas A&M Agricultural Conference. (2006).
  • Outstanding Clinical Research Associate, Pfizer Hellas/ Dept of Neurosciences. (2001).
  • Outstanding Clinical Research Associate, EUAGELISMOS Hospital/ Dept of Cardiovascular Diseases. (2000).

Research

Published Intellectual Contributions

    Atherosclerosis Thrombosis Vascular Biology

  • Calvier, L., Xian, X., Lee, R.G., Sacharidou, A., Mineo, C., Shaul, P.W., Kounnas, M.Z., Tsai, S., Herz, J. (2021). Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. No. 41 (4) 1309-1318. Philadephia, Pennsylvania, Lippincott Williams & Wilkins. https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.121.316000?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

    • Book Chapter

  • Stratman, A.N., Kim, D.J., Sacharidou, A., Speichinger, K.R., Davis, G.E. (2012). Methodologic Approaches to Investigate Vascular Tube Morphogenesis and Maturation Events in 3D Extracellular Matrices In Vitro and In Vivo. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. (978-94-007-4580-3 (print) and 978-94-007-4581-0 (online)) 101-126. Dordrecht, Springer Netherlands. https://doi.org/10.1007/978-94-007-4581-0_6
  • Davis, G.E., Stratman, A.N., Sacharidou, A., Koh, W. (2011). Molecular Basis for Endothelial Lumen Formation and Tubulogenesis During Vasculogenesis and Angiogenic Sprouting. International Review of Cell and Molecular Biology. 288 101-165. Amsterdam, Netherlands, Elsevier. https://doi.org/10.1016/b978-0-12-386041-5.00003-0
  • Davis, G.E., Stratman, A.N., Sacharidou, A. (2011). Molecular Control of Vascular Tube Morphogenesis and Stabilization: Regulation by Extracellular Matrix, Matrix Metalloproteinases, and Endothelial Cell–Pericyte Interactions. Biological and Medical Physics, Biomedical Engineering. (978-1-4419-7834-9 (print) and 978-1-4419-7835-6 (online)) 17-47. New York, New York, Springer New York. https://doi.org/10.1007/978-1-4419-7835-6_2
  • Koh, W., Stratman, A.N., Sacharidou, A., Davis, G.E. (2008). Chapter 5 In Vitro Three Dimensional Collagen Matrix Models of Endothelial Lumen Formation During Vasculogenesis and Angiogenesis. Methods in Enzymology. 443 (ISSN 0076-6879) 83-101. New York, New York (NY), Elsevier. https://doi.org/10.1016/s0076-6879(08)02005-3

    • Critical Review

  • Sacharidou, A., Shaul, P.W., Mineo, C. (2018). New Insights in the Pathophysiology of Antiphospholipid Syndrome. No. 44 (5) 475-482. New York, NY, Thieme Medical Publishers. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://pmc.ncbi.nlm.nih.gov/articles/PMC6333209/pdf/nihms-1005491.pdf
  • Sacharidou, A., Stratman, A.N., Davis, G.E. (2012). Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices. Other. No. 195 (1-2) 122-143. Basel-Stadt, Switzerland, S. Karger AG. https://doi.org/10.1159/000331410

    • Current Cardiology Reviews

  • Papaetis, G.S., Sacharidou, A., Michaelides, I.C., Mikellidis, K.C., Karvounaris, S.A. (2024). Insulin Resistance, Hyperinsulinemia and Atherosclerosis: Insights into Pathophysiological Aspects and Future Therapeutic Prospects. Other. No. 21 (1) 19. Potomac, Maryland (MD), Bentham Science Publishers Ltd.. https://doi.org/10.2174/011573403x314035241006185109

    • Journal Article

  • Yu, L., Xu, L., Peng, J., Sacharidou, A., Hsieh, H., Weinstock, A., Khan, S., Ma, L., Duran, J.G., McDonald, J., Nelson, E.R., Park, S., McDonnell, D.P., Moore, K.J., Huang, L.J., Fisher, E.A., Mineo, C., Huang, L., Shaul, P.W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature Communications. No. 14 (1401) 17. Ney York, NY, Nature Portofolio (part of Springer Nature). https://www.nature.com/articles/s41467-023-39586-z
  • Sacharidou, A., Chambliss, K., Peng, J., Barrera, J., Tanigaki, K., Luby-Phelps, K., Özdemir, İ., Khan, S., Sirsi, S.R., Kim, S.H., Katzenellenbogen, B.S., Katzenellenbogen, J.A., Kanchwala, M., Sathe, A.A., Lemoff, A., Xing, C., Hoyt, K., Mineo, C., Shaul, P.W. (2023). Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Nature Communications. No. 14 (1) 15. New York, New York (NY), Springer Science and Business Media LLC. https://doi.org/10.1038/s41467-023-40562-w
  • Sacharidou, A., Chu, H., Nguyen, A., Li, C., Chambliss, K.L., Salmon, J.E., Shen, Y., Lo, J., Leone, G.W., Herz, J., Hui, D.Y., Marciano, D.K., Abrahams, V.M., Natale, B.V., Montalbano, A.P., Xiao, X., Xu, L., Natale, D.R., Shaul, P.W., Mineo, C. (2021). Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circulation Research. No. 129 (7) 16. Philadelphia, Pennsylvania, Lippincott Williams & Wilkins. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318941?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
  • Calvier, L., Manouchehri, N., Sacharidou, A., Mineo, C., Shaul, P.W., Hui, D.Y., Kounnas, M.Z., Stüve, O., Herz, J. (2021). Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis. Other. No. 6 (62) Washington, DC, American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/sciimmunol.abd0931
  • Calvier, L., Demuth, G., Manoucherhri, N., Wong, C., Sacharidou, A., Mineo, C., Shaul, P.W., Monson, N.L., Kounnas, M.Z., Stuve, O., Herz, J. (2020). Reelin Depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes. No. 12 (556) 22. Washington, DC, American Association for the Advancement of Science. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://pmc.ncbi.nlm.nih.gov/articles/PMC7860587/pdf/nihms-1651677.pdf
  • Peng, J., Vongpatanasin, W., Sacharidou, A., Kifer, D., Yuhanna, I.S., Banerjee, S., Tanigaki, K., Polasek, O., Chu, H., Sundgren, N.C., Rohatgi, A., Chambliss, K.L., Lauc, G., Mineo, C., Shaul, P.W. (2019). Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. No. 140 (24) 2005-2018. New York, NY, Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circulationaha.119.043490
  • Sacharidou, A., Chambliss, K.L., Ulrich, V., Salmon, J.E., Shen, Y., Herz, J., Hui, D.Y., Terada, L.S., Shaul, P.W., Mineo, C. (2018). Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium (Plenary Paper). Blood. No. 131 (19) 2097-2110. Washington, DC, American Society of Hematology. https://pubmed.ncbi.nlm.nih.gov/29500169/
  • Tanigaki, K., Sacharidou, A., Peng, J., Chambliss, K.L., Yuhanna, I.S., Ghosh, D., Ahmed, M., Szalai, A.J., Vongpatanasin, W., Mattrey, R.F., Chen, Q., Azadi, P., Lingvay, I., Botto, M., Holland, W.L., Kohler, J.J., Sirsi, S.R., Hoyt, K., Shaul, P.W., Mineo, C. (2017). Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance. Other. No. 128 (1) 309-322. Iowa City, Iowa, American Society for Clinical Investigation. https://doi.org/10.1172/jci89333
  • Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y., Salmon, J.E., Brekken, R.A., Huang, X., Thorpe, P.E., Shaul, P.W., Zenclussen, A.C. (2016). Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis. PLOS One. No. 11 (7) e0158757. San Francisco, CA, Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0158757
  • Ulrich, V., Gelber, S.E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R.T., de Groot, P.G., Natale, D.R., Harihara, A., Redecha, P., Abrahams, V.M., Shaul, P.W., Salmon, J.E., Mineo, C. (2016). ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Other. No. 68 (3) 730-739. Hoboken, New Jersey, Wiley. https://doi.org/10.1002/art.39453
  • Lee, E.E., Ma, J., Sacharidou, A., Mi, W., Salato, V.K., Nguyen, N., Jiang, Y., Pascual, J.M., North, P.E., Shaul, P.W., Mettlen, M., Wang, R.C. (2015). A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome. Molecular Cell. No. 58 (5) 845-853. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1016/j.molcel.2015.04.015
  • Yuan, L., Le Bras, A., Sacharidou, A., Itagaki, K., Zhan, Y., Kondo, M., Carman, C.V., Davis, G.E., Aird, W.C., Oettgen, P. (2012). ETS-related Gene (ERG) Controls Endothelial Cell Permeability via Transcriptional Regulation of the Claudin 5 (CLDN5) Gene. Journal of Biological Chemistry. No. 287 (9) 6582-6591. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1074/jbc.m111.300236
  • Chan, A.C., Drakos, S.G., Ruiz, O.E., Smith, A.C., Gibson, C.C., Ling, J., Passi, S.F., Stratman, A.N., Sacharidou, A., Revelo, M.P., Grossmann, A.H., Diakos, N.A., Davis, G.E., Metzstein, M.M., Whitehead, K.J., Li, D.Y. (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. Other. No. 121 (5) 1871-1881. Iowa City, Iowa, American Society for Clinical Investigation. https://doi.org/10.1172/jci44393
  • Xu, K., Sacharidou, A., Fu, S., Chong, D.C., Skaug, B., Chen, Z.J., Davis, G.E., Cleaver, O. (2011). Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling. Developmental Cell. No. 20 (4) 526-539. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1016/j.devcel.2011.02.010
  • Sacharidou, A., Koh, W., Stratman, A.N., Mayo, A.M., Fisher, K.E., Davis, G.E. (2010). Endothelial lumen signaling complexes control 3D matrix–specific tubulogenesis through interdependent Cdc42- and MT1-MMP–mediated events. Blood. No. 115 (25) 5259-5269. Washington, District of Columbia (DC), American Society of Hematology. https://doi.org/10.1182/blood-2009-11-252692
  • Fisher, K.E., Sacharidou, A., Stratman, A.N., Mayo, A.M., Fisher, S.B., Mahan, R.D., Davis, M.J., Davis, G.E. (2009). MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. Journal of Cell Science. No. 122 (24) 4558-4569. Cambridge, United Kingdom, The Company of Biologists. https://doi.org/10.1242/jcs.050724
  • Stratman, A.N., Saunders, W.B., Sacharidou, A., Koh, W., Fisher, K.E., Zawieja, D.C., Davis, M.J., Davis, G.E. (2009). Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP–dependent proteolysis in 3-dimensional collagen matrices. Blood. No. 114 (2) 237-247. Washington, DC, American Society of Hematology. https://doi.org/10.1182/blood-2008-12-196451
  • Koh, W., Sachidanandam, K., Stratman, A.N., Sacharidou, A., Mayo, A.M., Murphy, E.A., Cheresh, D.A., Davis, G.E. (2009). Formation of endothelial lumens requires a coordinated PKCϵ-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal of Cell Science. No. 122 (11) 1812-1822. Cambridge, The Company of Biologists. https://doi.org/10.1242/jcs.045799

    • Journal Article in the Journal "Diabetes"

  • Tanigaki, K., Chambliss, K.L., Yuhanna, I.S., Sacharidou, A., Ahmed, M., Atochin, B.N., Huang, P.L., Shaul, P.W., Mineo, C. (2016). Endothelial FCg Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice. No. 65 (7) 1996-2005. Crystal City, Virginia, American Diabetes Association. https://diabetesjournals.org/diabetes/article/65/7/1996/16156/Endothelial-Fc-Receptor-IIB-Activation-Blunts

Service

University Service

  • Committee Member, Physiology and Neurobiology Division. (December 2024 - Present).
  • Member, Faculty Innovation Network (FIN)/ Division of Research and Innovation. (November 2024 - Present).
  • Committee Member, Faculty Search Committee member (Assistant Professor of Computational Biology). (November 2024 - Present).
  • Committee Member, Faculty Search Committee (Assistant Professor of Biology -Cancer Biologist). (October 2024 - Present).
  • Committee Member, Biochemistry and Molecular Biology Division/ Dept of Biological Sciences. (September 2024 - Present).

Professional Service

  • Member, NCFDD (National Center for Faculty Development and Diversity). (October 2024 - Present).
  • Member, NAVBO/ Early-Stage Investigators Group. (September 2024 - Present).
  • Reviewer, Ad Hoc Reviewer, Atherosclerosis journal. (January 2024 - Present).
  • Reviewer, Ad Hoc Reviewer, Molecular Medicine journal. (January 2024 - Present).
  • Committee Chair, Lean-In (while a junior faculty at UTSW). Dallas DFW, TX. (2022 - Present).