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Dr. Lin Li

Associate Professor

University of North Texas

Department of Biomedical Engineering

(940) 369-8707

Email: Lin.Li@unt.edu

Education

  • PhD, University of Texas at Arlington, 2015
    Major: Biomedical Engineering
  • BS, Huazhong University of Science and Technology, 2009
    Major: Optoelectronic Engineering

Licensures and Certifications

  • Animal Research, Collaborative Institutional Training Initiative (CITI Program). (2019 - 2022).

Professional Memberships

  • American Epilepsy Society. (January 01, 2015 - Present).
  • Society of Neuroscience. (January 01, 2015 - Present).

Development Activities

  • Workshop, Grant writing workshop, University of North Texas. Denton,TX,United States of America. (November 30, 2020 - December 3, 2020).
  • Tutorial, Faculty First Flight 2019-2020, University of North Texas. Denton,TX,United States of America. (September 1, 2019 - January 12, 2020).
  • Conference Attendance, AES Annual Meeting 2019, American Epilepsy Society. Baltimore,United States of America. (December 6, 2019 - December 10, 2019).
  • Conference Attendance, Neuroscience Annual Meeting 2019, Society of Neurosicence. Chicago,Illinois,United States of America. (October 19, 2019 - October 23, 2019).
  • Seminar, New Nanotechnologies to Understand and Manipulate Transport in the Brain, University of Texas at Arlington. Arlington,Texas,United States of America. (October 11, 2019 - October 11, 2019).
  • Seminar, Promotion & Tenure workshop, University of North Texas. Denton,TX,United States of America. (September 23, 2019 - September 23, 2019).
  • Seminar, New faculty orientation, University of North Texas. Denton,TX,United States of America. (August 13, 2019 - August 14, 2019).

Teaching

Teaching Experience

    University of North Texas

  • BMEN 2900 - Special Problems in Biomedical Engineering, 5 courses.
  • BMEN 3311 - Biomedical Signal Analysis, 23 courses.
  • BMEN 5005 - Neuroengineering, 1 course.
  • BMEN 5322 - Medical Imaging, 5 courses.
  • BMEN 5900 - Special Problems in Biomedical Engineering, 6 courses.
  • BMEN 5950 - Master's Thesis, 8 courses.
  • BMEN 6910 - Individual Research, 11 courses.
  • BMEN 6950 - Biomedical Engineering Doctoral Dissertation, 8 courses.
  • EENG 6940 - Individual Research, 3 courses.
  • MTSE 6940 - Individual Research, 6 courses.
  • MTSE 6950 - Doctoral Dissertation, 1 course.

Directed Student Learning

  • Master's Thesis Committee Chair, "Epilepsy Research," Biomedical Engineering. (September 2024).
  • Dissertation Committee Member, "Biological research on animal model," Biological Sciences. (January 2024).
  • Directed Individual/Independent Study, "Epilepsy research," Biomedical Engineering. (September 2023).
  • Directed Individual/Independent Study, "Epilepsy Research," Biomedical Engineering. (September 2023).
  • Dissertation Committee Chair, "Preclinical research of epilepsy," Biomedical Engineering. (September 2023).
  • Dissertation Committee Chair, "Computational Neuroscience," Biomedical Engineering. (September 2023).
  • Dissertation Committee Member, Biomedical Engineering. (September 2023).
  • Dissertation Committee Chair, "Medical imaging in preclinical research," Biomedical Engineering. (January 15, 2023).
  • Dissertation Defense Committee Chair, "In-vitro and in-vivo study of photobiomodulation as a novel antiepilepsy therapy," Biomedical Engineering. (September 1, 2019 - December 15, 2024).
  • Dissertation Defense Committee Chair, "Platform for automatic detection of epileptic features in clinical and translational applications," Biomedical Engineering. (September 1, 2019 - December 15, 2024).
  • Master's Thesis Committee Member, Biomedical Engineering. (January 2023 - May 2024).
  • Supervised Research, "Translational Research of Epilepsy," Biomedical Engineering. (September 2021 - May 2024).
  • Supervised Research, "Translational Research of Epilepsy," Biomedical Engineering. (September 2021 - May 2024).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (September 2021 - May 2023).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (November 2021 - May 2022).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (November 2021 - May 2022).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (November 2021 - May 2022).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (September 2021 - May 2022).
  • Supervised Research, "Translational reasearch for epilepsy," Other - Outside UNT. (January 1, 2021 - December 31, 2021).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (January 2020 - June 2021).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (September 2019 - June 2021).
  • Directed Individual/Independent Study, "Translational Research of Epilepsy," Texas Academy of Mathematics and Science. (September 2019 - June 2021).
  • Supervised Research, "Translational Research of Epilepsy," Other - Outside UNT. (January 2018 - December 2020).
  • Doctoral Comprehensive Exam Member or Grader, Biomedical Engineering. (September 12, 2019 - September 12, 2019).
  • Doctoral Comprehensive Exam Member or Grader, Biomedical Engineering. (September 12, 2019 - September 12, 2019).

Awards and Honors

  • Outstanding Research Faculty, University of North Texas. (May 2024).
  • Junior Faculty Summery Research Award, University of North Texas. (July 2020).
  • Young Investigator Award, American Epilepsy Society. (August 1, 2019).
  • Grass Young INvestigator Award, American Epilepsy Society. (August 1, 2017).

Research

Published Intellectual Contributions

    Conference Proceeding

  • Zhou, Y., You, J., Zhu, F., Bragin, A., Engel, J., Li, L. (2021). Automatic Electrophysiological Noise Reduction and Epileptic Seizure Detection for Stereoelectroencephalography. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE. http://dx.doi.org/10.1109/embc46164.2021.9630651
  • Ali, Z.A., Meng, N., Lin, L. Problem Based Learning: Key Learning from an Instructional Model Implementation with Client Partner. AECT Annual Convention Conference Proccedings. Bloomington, IN, Association of Educational Communications and Technology. https://aect.org/aects_annual_convention_proce.php
  • Li, L., Babawale, O., Cazzell, M., Liu, H. (2016). Assessment of resting-state brain networks in young and older adults by automatic voxel classification with atlas-guided diffuse optical tomography. Biomedical Optics 2016. OSA. http://dx.doi.org/10.1364/cancer.2016.jw3a.46
  • Li, L., Zeng, L., Cazzell, M., Liu, H. (2014). A statistical approach to assess measurement reliability of functional DOT for brain imaging. Biomedical Optics 2014. OSA. http://dx.doi.org/10.1364/biomed.2014.bm3a.27
  • Li, L., Cazzell, M., Liu, H. (2014). Investigation of age difference under risk decision-making using atlas-guided diffuse optical tomography. Biomedical Optics 2014. OSA. http://dx.doi.org/10.1364/biomed.2014.bm3a.26
  • Lin, Z., Li, L., Cazzell, M., Liu, H., Kollias, N., Choi, B., Zeng, H., Kang, H.W., Knudsen, B.E., Wong, B.J., Ilgner, J.F., Suter, M.J., Lam, S., Brenner, M., Gregory, K.W., Tearney, G.J., Marcu, L., Hirschberg, H., Madsen, S.J., Mahadevan-Jansen, A., Jansen, E.D., Mandelis, A., Morris, M.D. (2013). Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model. Photonic Therapeutics and Diagnostics IX. SPIE. http://dx.doi.org/10.1117/12.2005538
  • Li, L., Lin, Z., Cazzell, M., Liu, H., Kollias, N., Choi, B., Zeng, H., Kang, H.W., Knudsen, B.E., Wong, B.J., Ilgner, J.F., Suter, M.J., Lam, S., Brenner, M., Gregory, K.W., Tearney, G.J., Marcu, L., Hirschberg, H., Madsen, S.J., Mahadevan-Jansen, A., Jansen, E.D., Mandelis, A., Morris, M.D. (2013). Test-retest assessment of functional near-infrared spectroscopy to measure risk decision making in young adults. Photonic Therapeutics and Diagnostics IX. SPIE. http://dx.doi.org/10.1117/12.2005552
  • Lin, Z., Ren, M., Li, L., Yang, S., Liu, H. (2012). Diffuse optical tomography to study ischemic stroke in preclinical rat models. Biomedical Optics and 3-D Imaging. OSA. http://dx.doi.org/10.1364/biomed.2012.btu3a.32
  • Li, L., Lin, Z., Cazzell, M., Liu, H. (2012). Measurement of brain activations to examine gender-specific risk decision making using functional near infrared spectroscopy (fNIRS). Biomedical Optics and 3-D Imaging. OSA. http://dx.doi.org/10.1364/biomed.2012.btu3a.34
  • Niu, H., Li, L., Bhave, G.S., Lin, Z., Tian, F., Khosrow, B., Zhang, R., Liu, H. (2011). Investigation of cerebral hemodynamic changes during repeated sit-stand maneuver using functional near-infrared spectroscopy. Dynamics and Fluctuations in Biomedical Photonics VIII. SPIE. http://dx.doi.org/10.1117/12.875944

    • Journal Article

  • Tao, X., Kumar, U., Wang, M., Manglani, K., Zhu, C., Jones, M.R., Bombino, A., Bragin, A., Cole, G., Vossel, K., Engel, Jr., J., Frautschy, S.A., Li, L. (2025). Disruption of electrophysiological rhythms and memory impairment in an Alzheimer's transgenic rat model. Other. 17 (1) 200.
  • Truong, Q., Wang, M., Li, L., Chan, T. (2025). A genetic safeguard for eliminating target genes in synthetic probiotics in a gut environment. iScience. Cell Express.
  • Jafari, N., He, L., Khalil, C., Yeh, H.J., Harris, N.G., Stern, J.M., Engel, J., Bragin, A., Li, L. (2025). Intrinsic brain network stability during kainic acid‐induced epileptogenesis.
  • You, J., Fuchs, J.L., Wang, M., Hu, Q., Tao, X., Krolczyk, E., Tirumala, T., Bragin, A., Liu, H., Engel, J., Li, L. (2025). Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid-induced rat epilepsy model. 383 115005. Experimental Neurology.
  • Kang, S., Li, L., Shahdadian, S., Wu, A., Liu, H. (2025). Site-and electroencephalogram-frequency–specific effects of 800-nm prefrontal transcranial photobiomodulation on electroencephalogram global network topology in young adults. 12 (1) 015011-015011.
  • Meckes, B.R., Li, L., Chan, T. (2024). Sequence-Based Protein Design: A Review of Using Statistical Models to Characterize Coevolutionary Traits for Developing Hybrid Proteins as Genetic Sensors. International Journal of Molecular Sciences.
  • Wang, M., Dinarvand, D., Chan, T., Bragin, A., Li, L. (2024). Photobiomodulation as a Potential Treatment of Alzheimer’s Disease: A Review Paper. Brain Sciences.
  • Kinshuk, S., Li, L., Meckes, B.R., Chan, T. (2024). Sequence-Based Protein Design: A Review of Using Statistical Models to Characterize Coevolutionary Traits for Developing Hybrid Proteins as Genetic Sensors. International Journal of Molecular Sciences. 25 8320.
  • Zhu, F., Wang, H., Li, L., Bragin, A., Cao, D., Chen, Y. (2023). Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy.
  • Zhou, Y., You, J., Kumar, U., Weiss, S.A., Bragin, A., Engel, J., Papadelis, C., Li, L. (2022). An approach for reliably identifying high-frequency oscillations and reducing false-positive detections. Other. 7 (4) 674-686. Wiley Online. https://onlinelibrary.wiley.com/doi/full/10.1002/epi4.12647
  • Liu, A., Henin, S., Abbaspoor, S., Bragin, A., Buffalo, E., Farrell, J., Foster, D., Frank, L., Gedankien, T., Gotman, J., Guidera, J., Hoffman, K., Jacobs, J., Kahana, M., Li, L., Liao, Z., Lin, J., Losonczy, A., Malach, R., van der Meer, M., McClain, K., McNaughton, B., Norman, Y., Navas-Olive, A., Prida, L., Rueckemann, J., Sakon, J.J., Skelin, I., Soltesz, I., Staresina, B., Weiss, S.A., Wilson, M.A., Zaghloul, K.A., Zugaro, M., Buzsáki, G. (2022). A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations. Nature Communications. 13 (6000) Frontiers Media SA. https://www.nature.com/articles/s41467-022-33536-x
  • You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12 Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
  • Li, L., Kumar, U., You, J., Zhou, Y., Weiss, S.A., Engel, J., Bragin, A. (2021). Spatial and temporal profile of high-frequency oscillations in posttraumatic epileptogenesis. Other. 161 105544. Elsevier BV. http://dx.doi.org/10.1016/j.nbd.2021.105544
  • Kumar, U., Li, L., Bragin, A., Engel, J. (2021). Spike and wave discharges and fast ripples during posttraumatic epileptogenesis. Other. 62 (8) 1842-1851. Wiley. http://dx.doi.org/10.1111/epi.16958
  • You, J., Bragin, A., Liu, H., Li, L. (2021). Preclinical studies of transcranial photobiomodulation in the neurological diseases. Other. 3 (2) Wiley. http://dx.doi.org/10.1002/tbio.202000024
  • Li, L., He, L., Harris, N., Zhou, Y., Engel, J., Bragin, A. (2021). Topographical reorganization of brain functional connectivity during an early period of epileptogenesis. Other. 62 (5) 1231-1243. Wiley. http://dx.doi.org/10.1111/epi.16863
  • Choi, D., Li, L., Liu, H., Zeng, L. (2020). A recursive partitioning approach for subgroup identification in brain–behaviour correlation analysis. Other. 23 (1) 161-177. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s10044-018-00775-y
  • Cao, D., Chen, Y., Liao, J., Nariai, H., Li, L., Zhu, Y., Zhao, X., Hu, Y., Wen, F., Zhai, Q. (2019). Scalp EEG high frequency oscillations as a biomarker of treatment response in epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS). Other. 71 151-157. Elsevier BV. http://dx.doi.org/10.1016/j.seizure.2019.05.023
  • Li, L., Bragin, A., Staba, R., Engel, J. (2019). Unit firing and oscillations at seizure onset in epileptic rodents. Other. 127 382-389. Elsevier BV. http://dx.doi.org/10.1016/j.nbd.2019.03.027
  • Li, L., Kriukova, K., Engel, J., Bragin, A. (2018). Seizure development in the acute intrahippocampal epileptic focus. Scientific Reports. 8 (1) Springer Science and Business Media LLC. http://dx.doi.org/10.1038/s41598-018-19675-6
  • Li, L. (2018). Whole-cortical graphical networks at wakeful rest in young and older adults revealed by functional near-infrared spectroscopy. Other. 5 (03) 1. SPIE-Intl Soc Optical Eng. http://dx.doi.org/10.1117/1.nph.5.3.035004
  • Culaclii, S., Kim, B., Lo, Y., Li, L., Liu, W. (2018). Online Artifact Cancelation in Same-Electrode Neural Stimulation and Recording Using a Combined Hardware and Software Architecture. Other. 12 (3) 601-613. Institute of Electrical and Electronics Engineers (IEEE). http://dx.doi.org/10.1109/tbcas.2018.2816464
  • Li, L., Patel, M., Almajano, J., Engel, J., Bragin, A. (2018). Extrahippocampal high-frequency oscillations during epileptogenesis. Other. 59 (4) e51-e55. Wiley. http://dx.doi.org/10.1111/epi.14041
  • Li, L., Cazzell, M., Zeng, L., Liu, H. (2017). Are there gender differences in young vs. aging brains under risk decision-making? An optical brain imaging study. Other. 11 (4) 1085-1098. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s11682-016-9580-z
  • Li, L., Cazzell, M., Babawale, O., Liu, H. (2016). Automated voxel classification used with atlas-guided diffuse optical tomography for assessment of functional brain networks in young and older adults. Other. 3 (4) 045002. SPIE-Intl Soc Optical Eng. http://dx.doi.org/10.1117/1.nph.3.4.045002
  • Bragin, A., Li, L., Almajano, J., Alvarado-Rojas, C., Reid, A.Y., Staba, R.J., Engel, J. (2016). Pathologic electrographic changes after experimental traumatic brain injury. Other. 57 (5) 735-745. Wiley. http://dx.doi.org/10.1111/epi.13359
  • Li, L., Zeng, L., Lin, Z., Cazzell, M., Liu, H. (2015). Tutorial on use of intraclass correlation coefficients for assessing intertest reliability and its application in functional near-infrared spectroscopy–based brain imaging. Journal of Biomedical Optics. 20 (5) 050801. SPIE-Intl Soc Optical Eng. http://dx.doi.org/10.1117/1.jbo.20.5.050801
  • Lin, Z., Li, L., Cazzell, M., Liu, H. (2014). Atlas‐guided volumetric diffuse optical tomography enhanced by generalized linear model analysis to image risk decision‐making responses in young adults. Other. 35 (8) 4249-4266. Wiley. http://dx.doi.org/10.1002/hbm.22459
  • Lin, Z., Ren, M., Li, L., Liu, Y., Su, J., Yang, S., Liu, H. (2014). Interleaved imaging of cerebral hemodynamics and blood flow index to monitor ischemic stroke and treatment in rat by volumetric diffuse optical tomography. NeuroImage. 85 566-582. Elsevier BV. http://dx.doi.org/10.1016/j.neuroimage.2013.07.020
  • Lin, Z., Niu, H., Li, L., Liu, H. (2012). Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System. Other. 2012 1-10. Hindawi Limited. http://dx.doi.org/10.1155/2012/276367
  • Cazzell, M., Li, L., Lin, Z., Patel, S.J., Liu, H. (2012). Comparison of neural correlates of risk decision making between genders: An exploratory fNIRS study of the Balloon Analogue Risk Task (BART). NeuroImage. 62 (3) 1896-1911. Elsevier BV. http://dx.doi.org/10.1016/j.neuroimage.2012.05.030

Presentations Given

    Invited Talk

  • Li, L. (Presenter), 2021 IEEE MetroCon, DEVELOPMENT OF A REAL-TIME AUTOMATIC ELECTROPHYSIOLOGICAL NOISE REDUCTION ALGORITHM BASED ON DISCRETE SPECTRUM ANALYSIS, United States of America. (2021 - 2021).

    • Oral Presentation

  • Li, L. (Author & Presenter), 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Automatic Electrophysiological Noise Reduction and Epileptic Seizure Detection for Stereoelectroencephalography, United States of America. (2021 - 2021).
  • Li, L. (Author & Presenter), AES Annual meeting 2019, Electrograph Substrates of Altered Brain Networks during the Latent Period of Epileptogenesis, American Epilepsy Society, Baltimore, United States of America. (2019 - 2019).

    • Poster

  • Jafari, N. (Author & Presenter), Li, L. (Author), Divergent Brain Network Reorganizations in Post-Traumatic and Kainate- Induced Epileptogenesis, United States of America. (2025 - 2025).
  • Li, L. (Author & Presenter), Society of Neuroscience, Disruption of Electrophysiological Rhythms and Memory Impairment in an Alzheimer's Transgenic Rat Model, United States of America. (2025 - 2025).
  • You, J. (Author), Wang, M. (Author & Presenter), Hu, Q. (Author), Tao, X. (Author), Bragin, A. (Author), Engel, J. (Author), Liu, H. (Author), Li, L. (Author & Presenter), American Epilepsy Annual meeting, Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid induced rat epilepsy model, American Epilepsy Society, Los Angeles, United States of America. (2024 - 2024).
  • Zhou, Y. (Author & Presenter), Li, L. (Author), Society of Neuroscience, An approach for reliably identifying high-frequency oscillations and reducing false positive detections, Society of Neuroscience, Washington DC, United States of America. (2023 - 2023).
  • Tao, X. (Author & Presenter), Li, L. (Author), Society of Neuroscience, Interrupted hippocampal-cortical coupling associated with the decline of learning and memory performance after posttraumatic epilepsy., Society of Neuroscience, Washington DC, United States of America. (2023 - 2023).
  • Li, L. (Author & Presenter), AES 2022 Annual Meeting, High-frequency oscillations in a rat model of Alzheimer’s Disease, American Epilepsy Society, nashville, United States of America. (2022 - 2022).
  • Li, L. (Author & Presenter), Neuroscience Annual meeting 2022, Impaired hippocampal-prefrontal cortex connectivity with development of cognitive disfunction, Society of Neurosicence, san diego, United States of America. (2022 - 2022).
  • Li, L. (Author & Presenter), AES 2021 Annual Meeting, Spatial and Temporal Profile of High-frequency Oscillations in Posttraumatic Epileptogenesis, American Epilepsy Society, Chicago, United States of America. (2021 - 2021).
  • Li, L. (Author & Presenter), AES Annual meeting 2020, Topographical reorganization of brain functional during an early period of epileptogenesis, American Epilepsy Society, United States of America. (2020 - 2020).
  • Li, L. (Author & Presenter), Neuroscience Annual meeting 2019, Alterations of resting state functional brain connectivity in the early period of epileptogenesis - An EEG-fMRI combined study, Society of Neurosicence, Chicago, United States of America. (2019 - 2019).

Contracts, Grants, Sponsored Research

    Grant - Research

  • Engel, J. (Principal), Vossel, K. (Co-Principal), Staba, R. (Co-Principal), Bragin, A. (Co-Principal), Li, L. (Co-Principal), "In Vivo Studies of the Epileptic Hippocampus," sponsored by NIH, Federal, $6215421 Funded. (2023 - 2028).
  • Li, L. (Principal), "New approach for identification pHFO networks to predict epileptogenesis," sponsored by NIH, Federal, $720101 Funded. (2022 - 2026).
  • Meckes, B. (Principal), Li, L. (Principal), "Nanoparticles for Blood Brain Barrier Delivery," sponsored by University of North Texas, University of North Texas, $10000 Funded. (2022 - 2023).
  • Li, L. (Principal), "UCLA Neurology Epilepsy Data Evaluation," sponsored by University of California Los Angeles, University of North Texas, $35000 Funded. (2020 - 2022).
  • Li, L. (Principal), Fuchs, J. (Co-Principal), "Photobiomodulation on regulating Mitochondria Dysfunctions during Epileptogenesis," sponsored by University of North Texas, University of North Texas, $10000 Funded. (2021 - 2022).
  • Li, L. (Principal), "UCLA Neurology Epilepsy Data Evaluation," sponsored by The Regents of the University of, NFP, Funded. (2020 - 2022).

Service

University Service

  • Member, PAC. (September 24, 2025 - Present).
  • Committee Member, Graduate Curriculum Committee. (August 1, 2022 - Present).
  • Committee Member, BMEN Graduate Committee. (September 2020 - Present).
  • Committee Member, Undergraduate advising - senior level. (September 2019 - June 2020).

Professional Service

  • Committee Member, Pediatric Epilepsy Research Consortium. Niwot, CO. (April 7, 2023 - Present).
  • Editor, Guest Editor, Frontiers in Neurology. (June 2022 - Present).