Dr. Tsz Yan Clement Chan
University of North Texas
Biomedical Engineering
(940) 565-2154
Email:

Education

PhD, Massachusetts Institute of Technology, 2011.
Major: Biological Chemistry
Dissertation Title: A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
BS, University of Wisconsin-Madison, 2005.
Major: Biochemistry

Teaching

Teaching Experience

University of North Texas
BMEN 2900, Special Problems in Biomedical Engineering, 2 courses.
BMEN 4313, Cellular Engineering, 3 courses.
BMEN 4326, Principles of Biomolecular Engineering, 1 course.
BMEN 4980, Experimental Course, 2 courses.
BMEN 5313, Bioengineering of Cellular Systems, 6 courses.
BMEN 5326, Biomolecular Engineering, 1 course.
BMEN 5800, Topics in Biomedical Engineering, 5 courses.
BMEN 5900, Special Problems in Biomedical Engineering, 1 course.
BMEN 5950, Master's Thesis, 5 courses.
BMEN 6910, Individual Research, 4 courses.
BMEN 6930, Translational Biomedical Engineering, 2 courses.

Teaching at Other Institutions

University of Texas at Tyler, Molecular Biology for Modifying Organisms, BIOL 4302, Spring 2020.

University of Texas at Tyler, General Biology I, BIOL 1306, Spring 2019.

University of Texas at Tyler, Molecular Biology for Modifying Organisms, BIOL 4302, Spring 2019.

University of Texas at Tyler, General Biology II, BIOL 1307, Fall 2018.

University of Texas at Tyler, Molecular Biology for Modifying Organisms, BIOL 4302, Spring 2018.

University of Texas at Tyler, General Chemistry, CHEM 1311, Fall 2017.

Directed Student Learning

Master's Thesis Committee Member,"Developing a generalizable two-input genetic and-logic gate in Arabidopsis thaliana for multi-signal processing," Biological Sciences. (May 20, 2021October 31, 2022).

Master's Thesis Committee Member,"Engineering Whole Cell-Based Biosensors for Heavy Metal Detection Using Metalloregulatory Transcriptional Repressors of the SmtB/ArsR Family," Biomedical Engineering. (September 1, 2020May 15, 2022).

Research

Published Intellectual Contributions

Journal Article
You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12, . Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
Jiang, X., Dimas, R. P., Chan, C. T., Morcos, F. (2021). Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions. Nature Communications. 12, 5592. https://doi.org/10.1038/s41467-021-25851-6
Dimas, R. P., Jordan, B. R., Jiang, X., Martini, C., Glavy, J. S., Patterson, D. P., Morcos, F., Chan, T. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Other. 47(16), 8913-8925. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz666
Dimas, R. P., Jiang, X., Alberto de la Paz, J., Morcos, F., Chan, T. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Other. 47(10), 5449-5463. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz280
Lee, J. W., Chan, T., Slomovic, S., Collins, J. J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14(6), 530-537. https://api.elsevier.com/content/abstract/scopus_id/85047020981
Chan, T., Lee, J. W., Cameron, D. E., Bashor, C. J., Collins, J. J. (2016). 'Deadman' and 'Passcode' microbial kill switches for bacterial containment. Nature Chemical Biology. 12(2), 82-86. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nchembio.1979
Chan, T., Deng, W., Li, F., Demott, M. S., Babu, I. R., Begley, T. J., Dedon, P. C. (2015). Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28(5), 978-988. https://api.elsevier.com/content/abstract/scopus_id/84929408617
Dwyer, D. J., Belenky, P. A., Yang, J. H., Cody MacDonald,, Martell, J. D., Takahashi, N., Chan, T., Lobritz, M. A., Braff, D., Schwarz, E. G., Ye, J. D., Pati, M., Vercruysse, M., Ralifo, P. S., Allison, K. R., Khalil, A. S., Ting, A. Y., Walker, G. C., Collins, J. J. (2014). Antibiotics induce redox-related physi. Proceedings of the National Academy of Sciences of the United States of America. 111(20), . https://api.elsevier.com/content/abstract/scopus_id/84901059678
Mandal, D., Köhrer, C., Su, D., Babu, I. R., Chan, T., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P. C., Rajbhandary, U. L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Other. 20(2), 177-188. https://api.elsevier.com/content/abstract/scopus_id/84892739139
Su, D., Chan, T., Gu, C., Lim, K. S., Chionh, Y. H., McBee, M. E., Russell, B. S., Babu, I. R., Begley, T. J., Dedon, P. C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Other. 9(4), 828-841. https://api.elsevier.com/content/abstract/scopus_id/84897129376
Begley, U., Sosa, M. S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, T., Su, D., Dedon, P. C., Aguirre-Ghiso, J. A., Begley, T. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Other. 5(3), 366-383. https://api.elsevier.com/content/abstract/scopus_id/84874750617
Patil, A., Dyavaiah, M., Joseph, F., Rooney, J. P., Chan, T., Dedon, P. C., Begley, T. J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Other. 11(19), 3656-3665. https://api.elsevier.com/content/abstract/scopus_id/84867259656
Chan, T., Pang, Y. L., Deng, W., Babu, I. R., Dyavaiah, M., Begley, T. J., Dedon, P. C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3, . https://api.elsevier.com/content/abstract/scopus_id/84864828979
Patil, A., Chan, T., Dyavaiah, M., Rooney, J. P., Dedon, P. C., Begley, T. J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Other. 9(7), 990-1001. https://api.elsevier.com/content/abstract/scopus_id/84865298780
Chan, T., Chionh, Y. H., Ho, C., Lim, K. S., Babu, I. R., Ang, E., Wenwei, L., Alonso, S., Dedon, P. C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis bacille calmette-guérin. Molecules. 16(6), 5168-5181. https://api.elsevier.com/content/abstract/scopus_id/79959627017
Chan, T., Dyavaiah, M., DeMott, M. S., Taghizadeh, K., Dedon, P. C., Begley, T. J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Other. 6(12), 1-9. https://api.elsevier.com/content/abstract/scopus_id/78650683942
Fu, D., Brophy, J. A., Chan, T., Atmore, K. A., Begley, U., Paules, R. S., Dedon, P. C., Begley, T. J., Samson, L. D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30(10), 2449-2459. https://api.elsevier.com/content/abstract/scopus_id/77951981033
Seyedsayamdost, M. R., Chan, T., Mugnaini, V., Stubbe, J., Bennati, M. (2007). PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129(51), 15748-15749. https://api.elsevier.com/content/abstract/scopus_id/37549042071
Seyedsayamdost, M. R., Xie, J., Chan, T., Schultz, P. G., Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129(48), 15060-15071. https://api.elsevier.com/content/abstract/scopus_id/36849004028

Presentations Given

Invited Talk

Chan, C. (Author & Presenter), Southern Methodist University Department of Chemistry Seminar Series, Rationally modifying biochemical properties of transcriptional regulators for cellular applications, Southern Methodist University, Department of Chemistry, Virtual, United States of America. (20212021).

Chan, C. (Author & Presenter), UNT BioDiscovery Institute Seminar Series, Module Swapping of Transcriptional Regulators: A Strategy to Create Novel Cellular Behaviors, UNT BioDiscovery Institute, Virtual, United States of America. (20202020).

Oral Presentation

Chan, T. (Author & Presenter), DiscoverBMB 2023, Oral Presentation, ASBMB, Seattle, Washington, United States of America. (2023).

Chan, C. (Author & Presenter), ACS Spring 2022 Annual Meeting, Robust design of modular transcriptional regulators: New tools for building genetic devices, American Chemical Society, San Diego, California, United States of America. (2022).

Chan, T. (Author & Presenter), ASBMB Annual Meeting 2020, A module Swapping Approach to Engineering Allosterically Regulated Transcriptional Regulators, American Society of Biochemistry and Molecular Biology, Webinar, United States of America. (2020).

Chan, T. (Author & Presenter), Spring 2019 ASM Texas Branch Meeting, Creating biomonitoring devices with microbes—from protein engineering to genetic circuit development, American Society for Microbiology Texas Branch, New Braunfels, Texas, United States of America. (2019).

Contracts, Grants and Sponsored Research

Grant - Research
Chan, T., "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," Sponsored by National Institute of Health (Award # R35GM142421), Federal, $1525588 Funded. (20212026).
Chan, T., "NIH Instrument Supplement R35GM142421-03S1," Sponsored by NIH National Institute of General Medical Sciences, Federal, $247975 Funded. (September 1, 2023August 31, 2024).
Singh, R. (Principal), Chan, T. (Principal), Hu, M. (Principal), "Genetic Biocontainment Switch to Improve the Safety of Drug Detoxifying Bacteria in Preventing Chemotherapy-induced Diarrhea," Sponsored by National Institutes of Health/National Cancer Institute (R41CA275454), Federal, $399999 Funded. (April 1, 2023March 31, 2024).
Chan, C. (Principal), "DESIGN AND CONSTRUCT MODULAR TRANSCRIPTIONAL REPRESSORS TO FACILITATE THE DEVELOPMENT OF LIVING DIAGNOSTICS," Sponsored by National Institutes of Health (Award # 1R15GM135813-01), Federal, $391722 Funded. (December 1, 2020November 30, 2023).
Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," Sponsored by National Science Foundation (Award # 1914538), Federal, $441684 Funded. (July 1, 2019August 30, 2020).

Copyrights, Patents

Patent
Chan, T., "Methods for robust design of modular repressors," US Patent App. 17/823,921. Regular, United States, Date Submitted to University: 2021 –. Date of Patent Application: 2023 –.

Awards and Honors

2022 Junior Faculty Research Award, UNT College of Engineering. (April 28, 2022 – Present).

Service

University Service

Committee Member, Computational Biology Faculty Search Committee. (October 1, 2023 – Present).

Chairperson, Scholarship Committee. (August 2022 – Present).

Committee Member, Executive Committee of BioDiscovery Institute. (June 1, 2022 – Present).

Member, Genomics Center Advisory Board. (2022 – Present).

Committee Member, BMEN Graduate Committee. (September 1, 2020 – Present).

Other, College Graduate Curriculum Commitee. (September 1, 2020 – Present).

Professional Service

Other, Chemosensors (Peer-reviewed Journal). (June 1, 2019 – Present).

Reviewer, Grant Proposal, National Science Foundation. (20212021).

Public Service

Grant Proposal Reviewer, External, National Science Institute and National Institutes of Health. (August 8, 2023August 9, 2023).

Consulting

For Profit Organization, SanarEntero, LLC, Online, United States of America. (May 2, 2022June 21, 2022).