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Dr. Tsz Yan Clement Chan

Assistant Professor

University of North Texas

Department of Biomedical Engineering

(940) 565-2154

Email: Tszyanclement.Chan@unt.edu

Education

  • PhD, Massachusetts Institute of Technology, 2011
    Major: Biological Chemistry
    Dissertation: A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
  • BS, University of Wisconsin-Madison, 2005
    Major: Biochemistry

Teaching

Teaching Experience

    University of North Texas

  • BMEN 2900 - Special Problems in Biomedical Engineering, 2 courses.
  • BMEN 4313 - Cellular Engineering, 4 courses.
  • BMEN 4326 - Principles of Biomolecular Engineering, 1 course.
  • BMEN 4980 - Experimental Course, 2 courses.
  • BMEN 5313 - Bioengineering of Cellular Systems, 7 courses.
  • BMEN 5326 - Biomolecular Engineering, 1 course.
  • BMEN 5800 - Topics in Biomedical Engineering, 5 courses.
  • BMEN 5900 - Special Problems in Biomedical Engineering, 1 course.
  • BMEN 5950 - Master's Thesis, 6 courses.
  • BMEN 6910 - Individual Research, 5 courses.
  • BMEN 6930 - Translational Biomedical Engineering, 2 courses.
  • BMEN 6950 - Biomedical Engineering Doctoral Dissertation, 1 course.

Teaching at Other Institutions

  • University of Texas at Tyler, BIOL 4302 Molecular Biology for Modifying Organisms, Spring 2020.
  • University of Texas at Tyler, BIOL 1306 General Biology I, Spring 2019.
  • University of Texas at Tyler, BIOL 4302 Molecular Biology for Modifying Organisms, Spring 2019.
  • University of Texas at Tyler, BIOL 1307 General Biology II, Fall 2018.
  • University of Texas at Tyler, BIOL 4302 Molecular Biology for Modifying Organisms, Spring 2018.
  • University of Texas at Tyler, CHEM 1311 General Chemistry, Fall 2017.

Directed Student Learning

  • Master's Thesis Committee Member, "Developing a generalizable two-input genetic and-logic gate in Arabidopsis thaliana for multi-signal processing," Biological Sciences. (May 20, 2021 - October 31, 2022).
  • Master's Thesis Committee Member, "Engineering Whole Cell-Based Biosensors for Heavy Metal Detection Using Metalloregulatory Transcriptional Repressors of the SmtB/ArsR Family," Biomedical Engineering. (September 1, 2020 - May 15, 2022).

Awards and Honors

  • 2022 Junior Faculty Research Award, UNT College of Engineering. (April 28, 2022).

Research

Published Intellectual Contributions

    Journal Article

  • Mathis, K., Chan, T., Meckes, B.R. (2024). Controlling Cell Interactions with DNA Directed Assembly. Advanced Healthcare Materials. Wiley. http://dx.doi.org/10.1002/adhm.202402876
  • Kinshuk, S., Li, L., Meckes, B.R., Chan, T. (2024). Sequence-Based Protein Design: A Review of Using Statistical Models to Characterize Coevolutionary Traits for Developing Hybrid Proteins as Genetic Sensors. International Journal of Molecular Sciences. 25 8320.
  • You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12 Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
  • Jiang, X., Dimas, R.P., Chan, C.T., Morcos, F. (2021). Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions. Nature Communications. 12 5592. https://doi.org/10.1038/s41467-021-25851-6
  • Dimas, R.P., Jordan, B.R., Jiang, X., Martini, C., Glavy, J.S., Patterson, D.P., Morcos, F., Chan, T. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Other. 47 (16) 8913-8925. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz666
  • Dimas, R.P., Jiang, X., Alberto de la Paz, J., Morcos, F., Chan, T. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Other. 47 (10) 5449-5463. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz280
  • Lee, J.W., Chan, T., Slomovic, S., Collins, J.J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14 (6) 530-537. https://api.elsevier.com/content/abstract/scopus_id/85047020981
  • Chan, T., Lee, J.W., Cameron, D.E., Bashor, C.J., Collins, J.J. (2016). 'Deadman' and 'Passcode' microbial kill switches for bacterial containment. Nature Chemical Biology. 12 (2) 82-86. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nchembio.1979
  • Chan, T., Deng, W., Li, F., Demott, M.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2015). Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28 (5) 978-988. https://api.elsevier.com/content/abstract/scopus_id/84929408617
  • Dwyer, D.J., Belenky, P.A., Yang, J.H., Cody MacDonald, Martell, J.D., Takahashi, N., Chan, T., Lobritz, M.A., Braff, D., Schwarz, E.G., Ye, J.D., Pati, M., Vercruysse, M., Ralifo, P.S., Allison, K.R., Khalil, A.S., Ting, A.Y., Walker, G.C., Collins, J.J. (2014). Antibiotics induce redox-related physi. Proceedings of the National Academy of Sciences of the United States of America. 111 (20) https://api.elsevier.com/content/abstract/scopus_id/84901059678
  • Mandal, D., Köhrer, C., Su, D., Babu, I.R., Chan, T., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P.C., Rajbhandary, U.L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Other. 20 (2) 177-188. https://api.elsevier.com/content/abstract/scopus_id/84892739139
  • Su, D., Chan, T., Gu, C., Lim, K.S., Chionh, Y.H., McBee, M.E., Russell, B.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Other. 9 (4) 828-841. https://api.elsevier.com/content/abstract/scopus_id/84897129376
  • Begley, U., Sosa, M.S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, T., Su, D., Dedon, P.C., Aguirre-Ghiso, J.A., Begley, T. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Other. 5 (3) 366-383. https://api.elsevier.com/content/abstract/scopus_id/84874750617
  • Patil, A., Dyavaiah, M., Joseph, F., Rooney, J.P., Chan, T., Dedon, P.C., Begley, T.J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Other. 11 (19) 3656-3665. https://api.elsevier.com/content/abstract/scopus_id/84867259656
  • Chan, T., Pang, Y.L., Deng, W., Babu, I.R., Dyavaiah, M., Begley, T.J., Dedon, P.C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3 https://api.elsevier.com/content/abstract/scopus_id/84864828979
  • Patil, A., Chan, T., Dyavaiah, M., Rooney, J.P., Dedon, P.C., Begley, T.J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Other. 9 (7) 990-1001. https://api.elsevier.com/content/abstract/scopus_id/84865298780
  • Chan, T., Chionh, Y.H., Ho, C., Lim, K.S., Babu, I.R., Ang, E., Wenwei, L., Alonso, S., Dedon, P.C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis bacille calmette-guérin. Molecules. 16 (6) 5168-5181. https://api.elsevier.com/content/abstract/scopus_id/79959627017
  • Chan, T., Dyavaiah, M., DeMott, M.S., Taghizadeh, K., Dedon, P.C., Begley, T.J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Other. 6 (12) 1-9. https://api.elsevier.com/content/abstract/scopus_id/78650683942
  • Fu, D., Brophy, J.A., Chan, T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J., Samson, L.D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30 (10) 2449-2459. https://api.elsevier.com/content/abstract/scopus_id/77951981033
  • Seyedsayamdost, M.R., Chan, T., Mugnaini, V., Stubbe, J., Bennati, M. (2007). PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129 (51) 15748-15749. https://api.elsevier.com/content/abstract/scopus_id/37549042071
  • Seyedsayamdost, M.R., Xie, J., Chan, T., Schultz, P.G., Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129 (48) 15060-15071. https://api.elsevier.com/content/abstract/scopus_id/36849004028

Presentations Given

    Invited Talk

  • Chan, T. (Author & Presenter), 77th Annual Convention of the Texas Community College Teachers Association, Biomedical Engineering Research Experience for Undergraduates at University of North Texas, Texas Community College Teachers Association, Frisco, TX, United States of America. (2024 - 2024).
  • Chan, C. (Author & Presenter), Southern Methodist University Department of Chemistry Seminar Series, Rationally modifying biochemical properties of transcriptional regulators for cellular applications, Southern Methodist University, Department of Chemistry, Virtual, United States of America. (2021 - 2021).
  • Chan, C. (Author & Presenter), UNT BioDiscovery Institute Seminar Series, Module Swapping of Transcriptional Regulators: A Strategy to Create Novel Cellular Behaviors, UNT BioDiscovery Institute, Virtual, United States of America. (2020).

    • Oral Presentation

  • Chan, T. (Author & Presenter), DiscoverBMB 2023, Oral Presentation, American Society of Biochemistry and Molecular Biology, Seattle, Washington, United States of America. (2023).
  • Chan, T. (Author & Presenter), Synthetic Biology Young Speaker Series (SynBYSS), Designing modular transcriptional regulators as genetic sensors, SynBYSS, Virtual, United States of America. (2023 - 2023).
  • Chan, C. (Author & Presenter), ACS Spring 2022 Annual Meeting, Robust design of modular transcriptional regulators: New tools for building genetic devices, American Chemical Society, San Diego, California, United States of America. (2022).
  • Chan, T. (Author & Presenter), ASBMB Annual Meeting 2020, A module Swapping Approach to Engineering Allosterically Regulated Transcriptional Regulators, American Society of Biochemistry and Molecular Biology, Webinar, United States of America. (2020).
  • Chan, T. (Author & Presenter), Spring 2019 ASM Texas Branch Meeting, Creating biomonitoring devices with microbes—from protein engineering to genetic circuit development, American Society for Microbiology Texas Branch, New Braunfels, Texas, United States of America. (2019).

Contracts, Grants, Sponsored Research

    Grant - Research

  • Chan, T., "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institute of Health (Award # R35GM142421), Federal, $1525588 Funded. (2021 - 2026).
  • Chan, T., "NIH Instrument Supplement R35GM142421-03S1," sponsored by NIH National Institute of General Medical Sciences, Federal, $247975 Funded. (2023 - 2024).
  • Singh, R. (Principal), Chan, T. (Principal), Hu, M. (Principal), "Genetic Biocontainment Switch to Improve the Safety of Drug Detoxifying Bacteria in Preventing Chemotherapy-induced Diarrhea," sponsored by National Institutes of Health/National Cancer Institute (R41CA275454), Federal, $399999 Funded. (2023 - 2024).
  • Chan, C. (Principal), "DESIGN AND CONSTRUCT MODULAR TRANSCRIPTIONAL REPRESSORS TO FACILITATE THE DEVELOPMENT OF LIVING DIAGNOSTICS," sponsored by National Institutes of Health (Award # 1R15GM135813-01), Federal, $391722 Funded. (2020 - 2023).
  • Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, $441684 Funded. (2019 - 2020).
  • Chan, T. (Principal), "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institutes of Health, FED, Funded. (2021 - 2026).
  • Chan, T. (Principal), "Design and construct modular transcriptional repressors to facilitate the development of living diagnostics," sponsored by National Institutes of Health, FED, Funded. (2020 - 2023).
  • Chan, T. (Supporting), Wang, X. (Principal), "Development of Drug Detoxifying Bacteria for Chemotherapy Induced Gut Injury," sponsored by Sanarentero LLC, IND, Funded. (2021 - 2022).
  • Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, Funded. (2019 - 2020).

Copyrights, Patents

    Patent

  • Chan, T., Methods for robust design of modular repressors, US Patent App. 17/823,921. Regular, Date submitted to the University: 2021. Date of Patent Application: 2023. .

Service

University Service

  • Committee Member, Computational Biology Faculty Search Committee. (October 1, 2023 - Present).
  • Chairperson, Scholarship Committee. (August 2022 - Present).
  • Committee Member, Executive Committee of BioDiscovery Institute. (June 1, 2022 - Present).
  • Member, Genomics Center Advisory Board. (2022 - Present).
  • Committee Member, BMEN Graduate Committee. (September 1, 2020 - Present).
  • Other (Representative for the Department of Biomedical Engineering), College Graduate Curriculum Commitee. (September 1, 2020 - August 31, 2021).

Public Service

  • Grant Proposal Reviewer, External, National Science Institute and National Institutes of Health. (August 8, 2023 - August 9, 2023).

Professional Service

  • Committee Member, SynBYSS Conference Committee. (2023 - Present).
  • Other (Topic Editor), Chemosensors (Peer-reviewed Journal). (June 1, 2019 - Present).
  • Reviewer, Grant Proposal, National Science Foundation. (2021 - 2021).

Consulting

  • For Profit Organization, SanarEntero, LLC, Online, United States of America. (May 2, 2022 - June 21, 2022).