Anastasia Sacharidou

Previous Scheduled Teaching

Published Intellectual Contributions

Atherosclerosis Thrombosis Vascular Biology

• Calvier, L., Xian, X., Lee, R.G., Sacharidou, A., Mineo, C., Shaul, P.W., Kounnas, M.Z., Tsai, S., Herz, J. (2021). Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. No. 41 (4) 1309-1318. Philadephia, Pennsylvania, Lippincott Williams & Wilkins. https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.121.316000?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Book Chapter

• Stratman, A.N., Kim, D.J., Sacharidou, A., Speichinger, K.R., Davis, G.E. (2012). Methodologic Approaches to Investigate Vascular Tube Morphogenesis and Maturation Events in 3D Extracellular Matrices In Vitro and In Vivo. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. (978-94-007-4580-3 (print) and 978-94-007-4581-0 (online)) 101-126. Dordrecht, Springer Netherlands. https://doi.org/10.1007/978-94-007-4581-0_6
• Davis, G.E., Stratman, A.N., Sacharidou, A., Koh, W. (2011). Molecular Basis for Endothelial Lumen Formation and Tubulogenesis During Vasculogenesis and Angiogenic Sprouting. International Review of Cell and Molecular Biology. 288 101-165. Amsterdam, Netherlands, Elsevier. https://doi.org/10.1016/b978-0-12-386041-5.00003-0
• Davis, G.E., Stratman, A.N., Sacharidou, A. (2011). Molecular Control of Vascular Tube Morphogenesis and Stabilization: Regulation by Extracellular Matrix, Matrix Metalloproteinases, and Endothelial Cell–Pericyte Interactions. Biological and Medical Physics, Biomedical Engineering. (978-1-4419-7834-9 (print) and 978-1-4419-7835-6 (online)) 17-47. New York, New York, Springer New York. https://doi.org/10.1007/978-1-4419-7835-6_2
• Koh, W., Stratman, A.N., Sacharidou, A., Davis, G.E. (2008). Chapter 5 In Vitro Three Dimensional Collagen Matrix Models of Endothelial Lumen Formation During Vasculogenesis and Angiogenesis. Methods in Enzymology. 443 (ISSN 0076-6879) 83-101. New York, New York (NY), Elsevier. https://doi.org/10.1016/s0076-6879(08)02005-3

Critical Review

• Sacharidou, A., Shaul, P.W., Mineo, C. (2018). New Insights in the Pathophysiology of Antiphospholipid Syndrome. No. 44 (5) 475-482. New York, NY, Thieme Medical Publishers. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://pmc.ncbi.nlm.nih.gov/articles/PMC6333209/pdf/nihms-1005491.pdf
• Sacharidou, A., Stratman, A.N., Davis, G.E. (2012). Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices. Other. No. 195 (1-2) 122-143. Basel-Stadt, Switzerland, S. Karger AG. https://doi.org/10.1159/000331410

Current Cardiology Reviews

• Papaetis, G.S., Sacharidou, A., Michaelides, I.C., Mikellidis, K.C., Karvounaris, S.A. (2024). Insulin Resistance, Hyperinsulinemia and Atherosclerosis: Insights into Pathophysiological Aspects and Future Therapeutic Prospects. Other. No. 21 (1) 19. Potomac, Maryland (MD), Bentham Science Publishers Ltd.. https://doi.org/10.2174/011573403x314035241006185109

Journal Article

• Yu, L., Xu, L., Peng, J., Sacharidou, A., Hsieh, H., Weinstock, A., Khan, S., Ma, L., Duran, J.G., McDonald, J., Nelson, E.R., Park, S., McDonnell, D.P., Moore, K.J., Huang, L.J., Fisher, E.A., Mineo, C., Huang, L., Shaul, P.W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature Communications. No. 14 (1401) 17. Ney York, NY, Nature Portofolio (part of Springer Nature). https://www.nature.com/articles/s41467-023-39586-z
• Sacharidou, A., Chambliss, K., Peng, J., Barrera, J., Tanigaki, K., Luby-Phelps, K., Özdemir, İ., Khan, S., Sirsi, S.R., Kim, S.H., Katzenellenbogen, B.S., Katzenellenbogen, J.A., Kanchwala, M., Sathe, A.A., Lemoff, A., Xing, C., Hoyt, K., Mineo, C., Shaul, P.W. (2023). Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Nature Communications. No. 14 (1) 15. New York, New York (NY), Springer Science and Business Media LLC. https://doi.org/10.1038/s41467-023-40562-w
• Sacharidou, A., Chu, H., Nguyen, A., Li, C., Chambliss, K.L., Salmon, J.E., Shen, Y., Lo, J., Leone, G.W., Herz, J., Hui, D.Y., Marciano, D.K., Abrahams, V.M., Natale, B.V., Montalbano, A.P., Xiao, X., Xu, L., Natale, D.R., Shaul, P.W., Mineo, C. (2021). Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circulation Research. No. 129 (7) 16. Philadelphia, Pennsylvania, Lippincott Williams & Wilkins. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318941?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
• Calvier, L., Manouchehri, N., Sacharidou, A., Mineo, C., Shaul, P.W., Hui, D.Y., Kounnas, M.Z., Stüve, O., Herz, J. (2021). Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis. Other. No. 6 (62) Washington, DC, American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/sciimmunol.abd0931
• Calvier, L., Demuth, G., Manoucherhri, N., Wong, C., Sacharidou, A., Mineo, C., Shaul, P.W., Monson, N.L., Kounnas, M.Z., Stuve, O., Herz, J. (2020). Reelin Depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes. No. 12 (556) 22. Washington, DC, American Association for the Advancement of Science. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://pmc.ncbi.nlm.nih.gov/articles/PMC7860587/pdf/nihms-1651677.pdf
• Peng, J., Vongpatanasin, W., Sacharidou, A., Kifer, D., Yuhanna, I.S., Banerjee, S., Tanigaki, K., Polasek, O., Chu, H., Sundgren, N.C., Rohatgi, A., Chambliss, K.L., Lauc, G., Mineo, C., Shaul, P.W. (2019). Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. No. 140 (24) 2005-2018. New York, NY, Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circulationaha.119.043490
• Sacharidou, A., Chambliss, K.L., Ulrich, V., Salmon, J.E., Shen, Y., Herz, J., Hui, D.Y., Terada, L.S., Shaul, P.W., Mineo, C. (2018). Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium (Plenary Paper). Blood. No. 131 (19) 2097-2110. Washington, DC, American Society of Hematology. https://pubmed.ncbi.nlm.nih.gov/29500169/
• Tanigaki, K., Sacharidou, A., Peng, J., Chambliss, K.L., Yuhanna, I.S., Ghosh, D., Ahmed, M., Szalai, A.J., Vongpatanasin, W., Mattrey, R.F., Chen, Q., Azadi, P., Lingvay, I., Botto, M., Holland, W.L., Kohler, J.J., Sirsi, S.R., Hoyt, K., Shaul, P.W., Mineo, C. (2017). Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance. Other. No. 128 (1) 309-322. Iowa City, Iowa, American Society for Clinical Investigation. https://doi.org/10.1172/jci89333
• Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y., Salmon, J.E., Brekken, R.A., Huang, X., Thorpe, P.E., Shaul, P.W., Zenclussen, A.C. (2016). Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis. PLOS One. No. 11 (7) e0158757. San Francisco, CA, Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0158757
• Ulrich, V., Gelber, S.E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R.T., de Groot, P.G., Natale, D.R., Harihara, A., Redecha, P., Abrahams, V.M., Shaul, P.W., Salmon, J.E., Mineo, C. (2016). ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Other. No. 68 (3) 730-739. Hoboken, New Jersey, Wiley. https://doi.org/10.1002/art.39453
• Lee, E.E., Ma, J., Sacharidou, A., Mi, W., Salato, V.K., Nguyen, N., Jiang, Y., Pascual, J.M., North, P.E., Shaul, P.W., Mettlen, M., Wang, R.C. (2015). A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome. Molecular Cell. No. 58 (5) 845-853. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1016/j.molcel.2015.04.015
• Yuan, L., Le Bras, A., Sacharidou, A., Itagaki, K., Zhan, Y., Kondo, M., Carman, C.V., Davis, G.E., Aird, W.C., Oettgen, P. (2012). ETS-related Gene (ERG) Controls Endothelial Cell Permeability via Transcriptional Regulation of the Claudin 5 (CLDN5) Gene. Journal of Biological Chemistry. No. 287 (9) 6582-6591. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1074/jbc.m111.300236
• Chan, A.C., Drakos, S.G., Ruiz, O.E., Smith, A.C., Gibson, C.C., Ling, J., Passi, S.F., Stratman, A.N., Sacharidou, A., Revelo, M.P., Grossmann, A.H., Diakos, N.A., Davis, G.E., Metzstein, M.M., Whitehead, K.J., Li, D.Y. (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. Other. No. 121 (5) 1871-1881. Iowa City, Iowa, American Society for Clinical Investigation. https://doi.org/10.1172/jci44393
• Xu, K., Sacharidou, A., Fu, S., Chong, D.C., Skaug, B., Chen, Z.J., Davis, G.E., Cleaver, O. (2011). Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling. Developmental Cell. No. 20 (4) 526-539. Amsterdam, Netherlands, Elsevier BV. https://doi.org/10.1016/j.devcel.2011.02.010
• Sacharidou, A., Koh, W., Stratman, A.N., Mayo, A.M., Fisher, K.E., Davis, G.E. (2010). Endothelial lumen signaling complexes control 3D matrix–specific tubulogenesis through interdependent Cdc42- and MT1-MMP–mediated events. Blood. No. 115 (25) 5259-5269. Washington, District of Columbia (DC), American Society of Hematology. https://doi.org/10.1182/blood-2009-11-252692
• Fisher, K.E., Sacharidou, A., Stratman, A.N., Mayo, A.M., Fisher, S.B., Mahan, R.D., Davis, M.J., Davis, G.E. (2009). MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. Journal of Cell Science. No. 122 (24) 4558-4569. Cambridge, United Kingdom, The Company of Biologists. https://doi.org/10.1242/jcs.050724
• Stratman, A.N., Saunders, W.B., Sacharidou, A., Koh, W., Fisher, K.E., Zawieja, D.C., Davis, M.J., Davis, G.E. (2009). Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP–dependent proteolysis in 3-dimensional collagen matrices. Blood. No. 114 (2) 237-247. Washington, DC, American Society of Hematology. https://doi.org/10.1182/blood-2008-12-196451
• Koh, W., Sachidanandam, K., Stratman, A.N., Sacharidou, A., Mayo, A.M., Murphy, E.A., Cheresh, D.A., Davis, G.E. (2009). Formation of endothelial lumens requires a coordinated PKCϵ-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal of Cell Science. No. 122 (11) 1812-1822. Cambridge, The Company of Biologists. https://doi.org/10.1242/jcs.045799

Journal Article in the Journal "Diabetes"

• Tanigaki, K., Chambliss, K.L., Yuhanna, I.S., Sacharidou, A., Ahmed, M., Atochin, B.N., Huang, P.L., Shaul, P.W., Mineo, C. (2016). Endothelial FCg Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice. No. 65 (7) 1996-2005. Crystal City, Virginia, American Diabetes Association. https://diabetesjournals.org/diabetes/article/65/7/1996/16156/Endothelial-Fc-Receptor-IIB-Activation-Blunts