Anastasia Sacharidou

Previous Scheduled Teaching

Published Intellectual Contributions

Abstracts and Proceedings

• Koh, W., Sacharidou, A., Fisher, K.E., Davis, G.E. (2008). Cdc42/alpha2beta1 integrin/membrane type‐1 metalloproteinase complexes regulate endothelial lumen formation in 3D collagen matrices. Other. 22 (S1) 1. Rockville, Maryland, Wiley. https://doi.org/10.1096/fasebj.22.1_supplement.49.7
• Davis, G.E., Stratman, A.N., Koh, W., Sacharidou, A., Davis, M.J. (2008). Control of microvascular tube assembly by endothelial cell‐pericyte interactions. Other. 22 (S1) 1. Rockville, Maryland, Wiley. https://doi.org/10.1096/fasebj.22.1_supplement.383.1
• Davis, G.E., Koh, W., Sacharidou, A., Fisher, K.E. (2007). Role of extracellular matrix in vascular morphogenesis. Other. 21 (5) 1. Rockville, Maryland, Wiley. https://doi.org/10.1096/fasebj.21.5.a82-b

Atherosclerosis Thrombosis Vascular Biology

• Calvier, L., Xian, X., Lee, R.G., Sacharidou, A., Mineo, C., Shaul, P.W., Kounnas, M.Z., Tsai, S., Herz, J. (2021). Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. No. 41 (4) 1309-1318. Philadephia, Pennsylvania, Lippincott Williams & Wilkins. https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.121.316000?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Book Chapter

• Stratman, A.N., Kim, D.J., Sacharidou, A., Speichinger, K.R., Davis, G.E. (2012). Methodologic Approaches to Investigate Vascular Tube Morphogenesis and Maturation Events in 3D Extracellular Matrices In Vitro and In Vivo. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. (978-94-007-4580-3 (print) and 978-94-007-4581-0 (online)) 101-126. Dordrecht, Springer Netherlands. https://doi.org/10.1007/978-94-007-4581-0_6
• Davis, G.E., Stratman, A.N., Sacharidou, A. (2011). Molecular Control of Vascular Tube Morphogenesis and Stabilization: Regulation by Extracellular Matrix, Matrix Metalloproteinases, and Endothelial Cell–Pericyte Interactions. Biological and Medical Physics, Biomedical Engineering. (978-1-4419-7834-9 (print) and 978-1-4419-7835-6 (online)) 17-47. New York, New York, Springer New York. https://doi.org/10.1007/978-1-4419-7835-6_2
• Koh, W., Stratman, A.N., Sacharidou, A., Davis, G.E. (2008). Chapter 5 In Vitro Three Dimensional Collagen Matrix Models of Endothelial Lumen Formation During Vasculogenesis and Angiogenesis. Methods in Enzymology. 443 (ISSN 0076-6879) 83-101. Cambridge, Massachusetts, Elsevier. https://doi.org/10.1016/s0076-6879(08)02005-3

Critical Review

• Papaetis, G.S., Picolos, M.K., Sacharidou, A. (2025). Pioglitazone with SGLT2 inhibitors or GLP-1 receptor agonists in patients with type 2 diabetes and non-alcoholic fatty liver disease: could the combinations of an old friend with new players yield better outcomes?. Other. 10 (1) 1-15. Poznan, Termedia Publishing House. https://doi.org/10.5114/amsad/202298
• Papaetis, G.S., Sacharidou, A., Michaelides, I.C., Mikellidis, K.C., Karvounaris, S.A. (2025). Insulin Resistance, Hyperinsulinemia and Atherosclerosis: Insights into Pathophysiological Aspects and Future Therapeutic Prospects. Other. No. 21 (1) 19. Dubai, Bentham Science Publishers Ltd.. https://doi.org/10.2174/011573403x314035241006185109
• Sacharidou, A., Shaul, P.W., Mineo, C. (2018). New Insights in the Pathophysiology of Antiphospholipid Syndrome. Other. No. 44 (5) 475-482. New York, NY, Thieme Medical Publishers. https://doi.org/10.1055/s-0036-1597286
• Sacharidou, A., Stratman, A.N., Davis, G.E. (2012). Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices. Other. No. 195 (1-2) 122-143. Basel-Stadt, Switzerland, S. Karger AG. https://doi.org/10.1159/000331410
• Davis, G.E., Stratman, A.N., Sacharidou, A., Koh, W. (2011). Molecular Basis for Endothelial Lumen Formation and Tubulogenesis During Vasculogenesis and Angiogenic Sprouting. no. 288 (n/a) 101-165. Amsterdam, Elsevier. https://doi.org/10.1016/b978-0-12-386041-5.00003-0

Journal Article

• Sacharidou, A., Chambliss, K.L., Peng, J., Tanigaki, K., Islam, M.N., Sirsi, S., Lemoff, A., Hoyt, K., Mineo, C., Shaul, P.W. (2025). Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle. Other. No. 101 (102238) 9. Munich, Elsevier BV. https://doi.org/10.1016/j.molmet.2025.102238
• Sacharidou, A., Chambliss, K., Peng, J., Barrera, J., Tanigaki, K., Luby-Phelps, K., Özdemir, İ., Khan, S., Sirsi, S.R., Kim, S.H., Katzenellenbogen, B.S., Katzenellenbogen, J.A., Kanchwala, M., Sathe, A.A., Lemoff, A., Xing, C., Hoyt, K., Mineo, C., Shaul, P.W. (2023). Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Nature Communications. No. 14 (1) 15. New York, New York (NY), Springer Science and Business Media LLC. https://doi.org/10.1038/s41467-023-40562-w
• Yu, L., Xu, L., Chu, H., Peng, J., Sacharidou, A., Hsieh, H., Weinstock, A., Khan, S., Ma, L., Durán, J.G., McDonald, J., Nelson, E.R., Park, S., McDonnell, D.P., Moore, K.J., Huang, L.J., Fisher, E.A., Mineo, C., Huang, L., Shaul, P.W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature Communications. No. 14 (1) 17. Ney York, NY, Nature Portofolio (part of Springer Nature). https://doi.org/10.1038/s41467-023-39586-z
• Sacharidou, A., Chu, H., Nguyen, A., Li, C., Chambliss, K.L., Salmon, J.E., Shen, Y., Lo, J., Leone, G.W., Herz, J., Hui, D.Y., Marciano, D.K., Abrahams, V.M., Natale, B.V., Montalbano, A.P., Xiao, X., Xu, L., Natale, D.R., Shaul, P.W., Mineo, C. (2021). Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circulation Research. No. 129 (7) 735-750. Philadelphia, Pennsylvania, Lippincott Williams & Wilkins. https://doi.org/10.1161/circresaha.120.318941
• Calvier, L., Manouchehri, N., Sacharidou, A., Mineo, C., Shaul, P.W., Hui, D.Y., Kounnas, M.Z., Stüve, O., Herz, J. (2021). Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis. Other. No. 6 (62) 15. Washington, DC, American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/sciimmunol.abd0931
• Calvier, L., Xian, X., Lee, R.G., Sacharidou, A., Mineo, C., Shaul, P.W., Kounnas, M.Z., Tsai, S., Herz, J. (2021). Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. Other. 41 (4) 1309-1318. Baltimore, Maryland, Lippincott Williams & Wilkins (Wolters Kluwer Health). https://doi.org/10.1161/atvbaha.121.316000
• Calvier, L., Demuth, G., Manoucherhri, N., Wong, C., Sacharidou, A., Mineo, C., Shaul, P.W., Monson, N.L., Kounnas, M.Z., Stuve, O., Herz, J. (2020). Reelin Depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes. Other. No. 12 (556) 22. Washington, DC, American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/scitranslmed.aay7675
• Peng, J., Vongpatanasin, W., Sacharidou, A., Kifer, D., Yuhanna, I.S., Banerjee, S., Tanigaki, K., Polasek, O., Chu, H., Sundgren, N.C., Rohatgi, A., Chambliss, K.L., Lauc, G., Mineo, C., Shaul, P.W. (2019). Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. No. 140 (24) 2005-2018. Philadelphia, Pennsylvania, Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circulationaha.119.043490
• Sacharidou, A., Chambliss, K.L., Ulrich, V., Salmon, J.E., Shen, Y., Herz, J., Hui, D.Y., Terada, L.S., Shaul, P.W., Mineo, C. (2018). Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium (Plenary Paper). Blood. No. 131 (19) 2097-2110. Washington, DC, American Society of Hematology. https://doi.org/10.1182/blood-2017-11-814681
• Tanigaki, K., Sacharidou, A., Peng, J., Chambliss, K.L., Yuhanna, I.S., Ghosh, D., Ahmed, M., Szalai, A.J., Vongpatanasin, W., Mattrey, R.F., Chen, Q., Azadi, P., Lingvay, I., Botto, M., Holland, W.L., Kohler, J.J., Sirsi, S.R., Hoyt, K., Shaul, P.W., Mineo, C. (2017). Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance. Other. No. 128 (1) 309-322. Ann Arbor, Michigan, American Society for Clinical Investigation. https://doi.org/10.1172/jci89333
• Tanigaki, K., Chambliss, K.L., Yuhanna, I.S., Sacharidou, A., Ahmed, M., Atochin, D.N., Huang, P.L., Shaul, P.W., Mineo, C. (2016). Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice. Other. no. 65 (7) 1996-2005. Alexandria, Virginia, American Diabetes Association. https://doi.org/10.2337/db15-1605
• Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y., Salmon, J.E., Brekken, R.A., Huang, X., Thorpe, P.E., Shaul, P.W., Zenclussen, A.C. (2016). Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis. PLOS One. No. 11 (7) e0158757. San Francisco, CA, Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0158757
• Ulrich, V., Gelber, S.E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R.T., de Groot, P.G., Natale, D.R., Harihara, A., Redecha, P., Abrahams, V.M., Shaul, P.W., Salmon, J.E., Mineo, C. (2016). ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Other. No. 68 (3) 730-739. Malden, MA, Wiley. https://doi.org/10.1002/art.39453
• Lee, E.E., Ma, J., Sacharidou, A., Mi, W., Salato, V.K., Nguyen, N., Jiang, Y., Pascual, J.M., North, P.E., Shaul, P.W., Mettlen, M., Wang, R.C. (2015). A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome. Molecular Cell. No. 58 (5) 845-853. Cambridge, Massachusetts, Elsevier BV. https://doi.org/10.1016/j.molcel.2015.04.015
• Lee, W.R., Sacharidou, A., Behling-Kelly, E., Oltmann, S.C., Zhu, W., Ahmed, M., Gerard, R.D., Hui, D.Y., Abe, J., Shaul, P.W., Mineo, C., Zernecke, A. (2015). PDZK1 Prevents Neointima Formation via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle. PLOS One. 10 (4) 16. San Francisco, California, Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0124494
• Yuan, L., Le Bras, A., Sacharidou, A., Itagaki, K., Zhan, Y., Kondo, M., Carman, C.V., Davis, G.E., Aird, W.C., Oettgen, P. (2012). ETS-related Gene (ERG) Controls Endothelial Cell Permeability via Transcriptional Regulation of the Claudin 5 (CLDN5) Gene. Journal of Biological Chemistry. No. 287 (9) 6582-6591. Rockville, Maryland, Elsevier BV. https://doi.org/10.1074/jbc.m111.300236
• Yuan, L., Sacharidou, A., Stratman, A.N., Le Bras, A., Zwiers, P.J., Spokes, K., Bhasin, M., Shih, S., Nagy, J.A., Molema, G., Aird, W.C., Davis, G.E., Oettgen, P. (2011). RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. no. 118 (4) 1145-1153. Washington, DC, American Society of Hematology. https://doi.org/10.1182/blood-2010-10-315275
• Chan, A.C., Drakos, S.G., Ruiz, O.E., Smith, A.C., Gibson, C.C., Ling, J., Passi, S.F., Stratman, A.N., Sacharidou, A., Revelo, M.P., Grossmann, A.H., Diakos, N.A., Davis, G.E., Metzstein, M.M., Whitehead, K.J., Li, D.Y. (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. Other. No. 121 (5) 1871-1881. Ann Arbor, Michigan, American Society for Clinical Investigation. https://doi.org/10.1172/jci44393
• Xu, K., Sacharidou, A., Fu, S., Chong, D.C., Skaug, B., Chen, Z.J., Davis, G.E., Cleaver, O. (2011). Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling. Developmental Cell. No. 20 (4) 526-539. Cambridge, Massachusetts, Elsevier BV. https://doi.org/10.1016/j.devcel.2011.02.010
• Sacharidou, A., Koh, W., Stratman, A.N., Mayo, A.M., Fisher, K.E., Davis, G.E. (2010). Endothelial lumen signaling complexes control 3D matrix–specific tubulogenesis through interdependent Cdc42- and MT1-MMP–mediated events. Blood. No. 115 (25) 5259-5269. Washington, District of Columbia (DC), American Society of Hematology. https://doi.org/10.1182/blood-2009-11-252692
• Fisher, K.E., Sacharidou, A., Stratman, A.N., Mayo, A.M., Fisher, S.B., Mahan, R.D., Davis, M.J., Davis, G.E. (2009). MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. Journal of Cell Science. No. 122 (24) 4558-4569. Cambridge, United Kingdom, The Company of Biologists. https://doi.org/10.1242/jcs.050724
• Stratman, A.N., Saunders, W.B., Sacharidou, A., Koh, W., Fisher, K.E., Zawieja, D.C., Davis, M.J., Davis, G.E. (2009). Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP–dependent proteolysis in 3-dimensional collagen matrices. Blood. No. 114 (2) 237-247. Washington, DC, American Society of Hematology. https://doi.org/10.1182/blood-2008-12-196451
• Koh, W., Sachidanandam, K., Stratman, A.N., Sacharidou, A., Mayo, A.M., Murphy, E.A., Cheresh, D.A., Davis, G.E. (2009). Formation of endothelial lumens requires a coordinated PKCϵ-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. Journal of Cell Science. No. 122 (11) 1812-1822. Cambridge, The Company of Biologists. https://doi.org/10.1242/jcs.045799
• Koh, W., Sacharidou, A., Fisher, K.E., Davis, G.E. (2007). Coordinated regulation by Cdc42, integrin alpha2beta1, and membrane type‐1 metalloproteinase‐dependant signaling of capillary tube formation in 3D collagen matrices. Other. 21 (5) 1. Rockville, Maryland, Wiley. https://doi.org/10.1096/fasebj.21.5.a14-b
• Halbig, K., Sacharidou, A., De Nova-Ocampo, M., Cruz-Reyes, J. (2006). Preferential interaction of a 25 kDa protein with an A6 pre-mRNA substrate for RNA editing in Trypanosoma brucei. International Journal for Parasitology. 36 (12) 1295-1304. Oxford, Oxfordshire, Elsevier BV. https://doi.org/10.1016/j.ijpara.2006.05.011
• RASIDAKIS, A., ORPHANIDOU, D., KALOMENIDIS, J., PAPAMICHALIS, G., TOUMBIS, M., LAMBADLOS, J., Sacharidou, A., PAPASTAMATIOU, H., JORDANOGLOU, J. (1998). Expression of mdm-2 Protein in Neoplastic, Preneoplastic, and Normal Bronchial Mucosa Specimens: Comparative Study with p53 Expression. Other. No. 17 (4) 339-345. New Rochelle, New York, Mary Ann Liebert Inc. https://doi.org/10.1089/hyb.1998.17.339