Brian R. Meckes

Previous Scheduled Teaching

Published Intellectual Contributions

Journal Article

• Kohon, A.I., Man, K., Hessami, A., Webb, J., Fang, J., Radfar, P., Yang, Y., Meckes, B.R. (2024). Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models. iScience. 27 (10)
• Mathis, K., Chan, T., Meckes, B.R. (2024). Controlling Cell Interactions with DNA Directed Assembly. Advanced Healthcare Materials. Wiley. http://dx.doi.org/10.1002/adhm.202402876
• Kinshuk, S., Li, L., Meckes, B.R., Chan, T. (2024). Sequence-Based Protein Design: A Review of Using Statistical Models to Characterize Coevolutionary Traits for Developing Hybrid Proteins as Genetic Sensors. International Journal of Molecular Sciences. 25 8320.
• Mathis, K., Gaddam, S., Koneru, R., Sunkavalli, N., Wang, C., Patel, M., Kohon, A.I., Meckes, B.R. (2024). Multifunctional hydrogels with spatially controlled light activation with photocaged oligonucleotides. Other. 5 (5) 101922. Elsevier BV. http://dx.doi.org/10.1016/j.xcrp.2024.101922
• Man, K., Liu, J., Liang, C., Corona, C., Story, M.D., Meckes, B.R., Yang, Y. (2023). Biomimetic human lung alveolar interstitium chip with extended longevity. Other. 15 (30) 36888--36898. ACS Publications.
• Wang, K., Man, K., Liu, J., Meckes, B.R., Yang, Y. (2023). Dissecting Physical and Biochemical Effects in Nanotopographical Regulation of Cell Behavior. ACS Nano. 17 (3) 2124--2133. American Chemical Society.
• Kohon, A.I., Man, K., Mathis, K., Webb, J., Yang, Y., Meckes, B.R. (2023). Nanoparticle targeting of mechanically modulated glycocalyx. Other. 10--1101. Cold Spring Harbor Laboratory.
• Mathis, K., Kohon, A.I., Black, S., Meckes, B.R. (2023). Light-Controlled Cell-Cell Assembly Using Photocaged Oligonucleotides. 3 (4) 386-393.
• Man, K., Liu, J., Liang, C., Corona, C., Story, M.D., Meckes, B.R., Yang, Y. (2022). Biomimetic Human Lung Alveolar Interstitium Chip with Extended Longevity. Cold Spring Harbor Laboratory. https://www.biorxiv.org/content/10.1101/2022.12.23.521822v1
• Lin, M., Meckes, B.R., Chen, C., Teplensky, M.H., Mirkin, C.A. (2022). Controlling Intracellular Machinery via Polymer Pen Lithography Molecular Patterning. Other. 8 (9) 1282-1289. American Chemical Society (ACS). http://dx.doi.org/10.1021/acscentsci.2c00683
• Zhang, W., Callmann, C.E., Meckes, B.R., Mirkin, C.A. (2022). Tumor-Associated Enzyme-Activatable Spherical Nucleic Acids. ACS Nano. 16 (7) 10931-10942. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsnano.2c03323
• Oh, E., Meckes, B.R., Chang, J., Shin, D., Mirkin, C.A. (2021). Controlled Glioma Cell Migration and Confinement Using Biomimetic-Patterned Hydrogels. Other. 2100131. Wiley Online Library.
• Ponedal, A., Zhu, S., Sprangers, A.J., Wang, X., Yeo, D.C., Lio, D.C., Zheng, M., Capek, M., Narayan, S.P., Meckes, B.R., Paller, A.S., Xu, C., Mirkin, C.A. (2020). Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1. Other. 3 (12) 8603-8610. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsabm.0c00990
• Chen, P., Liu, Y., Du, J.S., Meckes, B.R., Dravid, V.P., Mirkin, C.A. (2020). Chain-End Functionalized Polymers for the Controlled Synthesis of Sub-2 nm Particles. Journal of the American Chemical Society. 142 (16) 7350-7355. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.0c02244
• Zhang, W., Meckes, B.R., Mirkin, C.A. (2019). Spherical Nucleic Acids with Tailored and Active Protein Coronae. Other. 5 (12) 1983-1990. https://doi.org/10.1021/acscentsci.9b01105
• Cabezas, M.D., Meckes, B.R., Mirkin, C.A., Mrksich, M. (2019). Subcellular Control over Focal Adhesion Anisotropy, Independent of Cell Morphology, Dictates Stem Cell Fate. ACS Nano. https://doi.org/10.1021/acsnano.9b03937
• Chen, P., Liu, M., Du, J.S., Meckes, B.R., Wang, S., Lin, H., Dravid, V.P., Wolverton, C., Mirkin, C.A. (2019). Interface and heterostructure design in polyelemental nanoparticles. Science. 363 (6430) 959-964. American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/science.aav4302
• Kluender, E.J., Hedrick, J.L., Brown, K.A., Rao, R., Meckes, B.R., Du, J.S., Moreau, L.M., Maruyama, B., Mirkin, C.A. (2019). Catalyst discovery through megalibraries of nanomaterials. Proceedings of the National Academy of Sciences. 116 (1) 40-45. Proceedings of the National Academy of Sciences. http://dx.doi.org/10.1073/pnas.1815358116
• Du, J.S., Chen, P., Meckes, B.R., Kluender, E.J., Xie, Z., Dravid, V.P., Mirkin, C.A. (2018). Windowless Observation of Evaporation-Induced Coarsening of Au–Pt Nanoparticles in Polymer Nanoreactors. Journal of the American Chemical Society. 140 (23) 7213-7221. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.8b03105
• Meckes, B.R., Banga, R.J., Nguyen, S.T., Mirkin, C.A. (2018). Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid-Tail DNA Modifications. Small. 14 (5) 1702909. Wiley. http://dx.doi.org/10.1002/smll.201702909
• Xie, Z., Gordiichuk, P., Lin, Q., Meckes, B.R., Chen, P., Sun, L., Du, J.S., Zhu, J., Liu, Y., Dravid, V.P., Mirkin, C.A. (2017). Solution-Phase Photochemical Nanopatterning Enabled by High-Refractive-Index Beam Pen Arrays. ACS Nano. 11 (8) 8231-8241. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsnano.7b03282
• Chen, P., Du, J.S., Meckes, B.R., Huang, L., Xie, Z., Hedrick, J.L., Dravid, V.P., Mirkin, C.A. (2017). Structural Evolution of Three-Component Nanoparticles in Polymer Nanoreactors. Journal of the American Chemical Society. 139 (29) 9876-9884. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.7b03163
• Du, J.S., Chen, P., Meckes, B.R., Xie, Z., Zhu, J., Liu, Y., Dravid, V.P., Mirkin, C.A. (2017). The Structural Fate of Individual Multicomponent Metal-Oxide Nanoparticles in Polymer Nanoreactors. Angewandte Chemie International Edition. 56 (26) 7625-7629. Wiley. http://dx.doi.org/10.1002/anie.201703296
• Du, J.S., Chen, P., Meckes, B.R., Xie, Z., Zhu, J., Liu, Y., Dravid, V.P., Mirkin, C.A. (2017). The Structural Fate of Individual Multicomponent Metal-Oxide Nanoparticles in Polymer Nanoreactors. Other. 129 (26) 7733-7737. Wiley. http://dx.doi.org/10.1002/ange.201703296
• Banga, R.J., Meckes, B.R., Narayan, S.P., Sprangers, A.J., Nguyen, S.T., Mirkin, C.A. (2017). Cross-Linked Micellar Spherical Nucleic Acids from Thermoresponsive Templates. Journal of the American Chemical Society. 139 (12) 4278-4281. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.6b13359
• Hwang, M.T., Landon, P.B., Lee, J., Mo, A., Meckes, B.R., Glinsky, G., Lal, R. (2015). DNA nano-carrier for repeatable capture and release of biomolecules. Nanoscale. 7 (41) 17397-17403. Royal Society of Chemistry (RSC). http://dx.doi.org/10.1039/c5nr05124j
• Meckes, B.R., Arce, F.T., Connelly, L.S., Lal, R. (2015). Insulated Conducting Cantilevered Nanotips and Two-Chamber Recording System for High Resolution Ion Sensing AFM. Scientific Reports. 4 (1) Springer Science and Business Media LLC. http://dx.doi.org/10.1038/srep04454
• Meckes, B.R., Ambrosi, C., Barnard, H., Arce, F.T., Sosinsky, G.E., Lal, R. (2014). Atomic Force Microscopy Shows Connexin26 Hemichannel Clustering in Purified Membrane Fragments. Biochemistry. 53 (47) 7407-7414. American Chemical Society (ACS). http://dx.doi.org/10.1021/bi501265p
• Kwok, J., Grogan, S., Meckes, B.R., Arce, F., Lal, R., D’Lima, D. (2014). Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. Other. 10 (8) 1777-1785. Elsevier BV. http://dx.doi.org/10.1016/j.nano.2014.06.010
• Landon, P.B., Lee, J., Hwang, M.T., Mo, A.H., Zhang, C., Neuberger, A., Meckes, B.R., Gutierrez, J.J., Glinsky, G., Lal, R. (2014). Energetically Biased DNA Motor Containing a Thermodynamically Stable Partial Strand Displacement State. Langmuir. 30 (46) 14073-14078. American Chemical Society (ACS). http://dx.doi.org/10.1021/la503711g
• Alfonta, L., Meckes, B.R., Amir, L., Schlesinger, O., Ramachandran, S., Lal, R. (2014). Measuring Localized Redox Enzyme Electron Transfer in a Live Cell with Conducting Atomic Force Microscopy. Analytical Chemistry. 86 (15) 7674-7680. American Chemical Society (ACS). http://dx.doi.org/10.1021/ac5015645
• Connelly, L.S., Meckes, B.R., Larkin, J., Gillman, A.L., Wanunu, M., Lal, R. (2014). Graphene Nanopore Support System for Simultaneous High-Resolution AFM Imaging and Conductance Measurements. ACS Applied Materials & Interfaces. 6 (7) 5290-5296. American Chemical Society (ACS). http://dx.doi.org/10.1021/am500639q
• Mo, A.H., Landon, P.B., Meckes, B.R., Yang, M.M., Glinsky, G.V., Lal, R. (2013). An on-demand four-way junction DNAzyme nanoswitch driven by inosine-based partial strand displacement. Nanoscale. 6 (3) 1462-1466. Royal Society of Chemistry (RSC). http://dx.doi.org/10.1039/c3nr05365b
• Arce, F.T., Meckes, B.R., Camp, S.M., Garcia, J.G., Dudek, S.M., Lal, R. (2013). Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Other. 9 (7) 875-884. Elsevier BV. http://dx.doi.org/10.1016/j.nano.2013.03.006
• Leiske, D.L., Meckes, B.R., Miller, C.E., Wu, C., Walker, T.W., Lin, B., Meron, M., Ketelson, H.A., Toney, M.F., Fuller, G.G. (2011). Insertion Mechanism of a Poly(ethylene oxide)-poly(butylene oxide) Block Copolymer into a DPPC Monolayer. Langmuir. 27 (18) 11444-11450. American Chemical Society (ACS). http://dx.doi.org/10.1021/la2016879

Proceedings

• Montoya, B., Mittal, I., Scofield, S., Shah, J., Meckes, B. (2022). Spherical Nucleic Acids for Fusarium graminearum gene regulatio. Other. Minneapolis, Minnesota, US Wheat and Barley Scab Initiative.
• Montoya, B., Mittal, I., Shah, J., Meckes, B. (2021). Development of Biocompatible siRNA Nanoparticles to Mitigate FHB in Wheat. Other. 50. US Wheat and Barley Scab Initiative. https://scabusa.org/forum/2021/2021NFHBForumProceedings.pdf

Contracts, Grants and Sponsored Research

Fellowship

• Meckes, B., "Scanning Ion Conductance Microscope-array for the Study of Ion Channel Clusters," sponsored by NIH/NIDA, Federal, $103000 Funded. (2013 - 2015).
• Meckes, B., "Scanning Ion Conductance Microscope-array for the Study of Ion Channel Clusters," sponsored by NIH/NIDA, Federal, Funded. (2013 - 2015).

Grant - Research

• Meckes, B.R. (Principal), Yang, Y. (Co-Principal), "Lipidomics of Lung Fibrosis for Therapeutic Targeting," sponsored by University of North Texas, University of North Texas, $3000 Funded. (2023).
• Meckes, B.R., "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces," sponsored by NIH/NIGMS, Federal, $1798070 Funded. (2023 - 2028).
• Shah, J. (Principal), Meckes, B. (Co-Principal), "Spherical nucleic acid nanomaterials as fungicide and FHB resistance-promoting agents," sponsored by Agricultural Research Service, Federal, $115942 Funded. (2022 - 2024).
• Meckes, B., "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding," sponsored by NIH/NIGMS, Federal, $383151 Funded. (2021 - 2023).
• Meckes, B. (Principal), Li, L. (Principal), "Nanoparticles for Blood Brain Barrier Delivery," sponsored by University of North Texas, University of North Texas, $10000 Funded. (2022 - 2023).
• Meckes, B. (Principal), "Ralph Powe Junior Faculty Enhancement," sponsored by ORAU, Private, $10000 Funded. (2021 - 2022).
• Meckes, B. (Co-Principal), Shah, J. (Co-Principal), "Plant Exosome Mimics for Gene Regulation in Fungal Species Affecting Crops," sponsored by COS-CENG, University of North Texas, $10000 Funded. (2021 - 2021).
• Meckes, B.R. (Principal), "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding," sponsored by National Institutes of Health, FED, Funded. (2021 - 2023).
• Meckes, B.R. (Co-Principal), Shah, J. (Principal), "Molecular-genetic approaches to mitigate Fusarium head blight disease in wheat," sponsored by Agricultural Research Service, FED, Funded. (2021 - 2022).
• Meckes, B.R. (Principal), "Development of Nanolithographic Approaches to Determine Actin Force Regulation of Lipid Domains," sponsored by Oak Ridge Associated Universities, NFP, Funded. (2021 - 2022).