Faculty Profile

Brian Meckes

Title
Assistant Professor
Department
Biomedical Engineering
College
College of Engineering

    

Education

PhD, University of California, San Diego, 2015.
Major: Bioengineering
BS, Rice University, 2009.
Major: Bioengineering

Current Scheduled Teaching*

BMEN 6950.010, Biomedical Engineering Doctoral Dissertation, Fall 2024
BMEN 4007.001, Biomedical Experimental Design and Data Analysis, Fall 2024
BMEN 6910.008, Individual Research, Fall 2024
BMEN 5007.001, Research Methods in Biomedical Engineering, Fall 2024
BMEN 5007.601, Research Methods in Biomedical Engineering, Fall 2024
BMEN 5900.008, Special Problems in Biomedical Engineering, Summer 2024

* Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.

Previous Scheduled Teaching*

BMEN 5317.001, Advanced Biotechnology, Spring 2024 SPOT
BMEN 6950.008, Biomedical Engineering Doctoral Dissertation, Spring 2024
BMEN 5950.008, Master's Thesis, Spring 2024
BIOL 4900.781, Special Problems, Spring 2024
BMEN 5900.017, Special Problems in Biomedical Engineering, Spring 8W2 2024
BMEN 6950.010, Biomedical Engineering Doctoral Dissertation, Fall 2023
BMEN 4007.001, Biomedical Experimental Design and Data Analysis, Fall 2023 Syllabus SPOT
BMEN 6910.008, Individual Research, Fall 2023
BMEN 5950.003, Master's Thesis, Fall 2023
BMEN 5007.001, Research Methods in Biomedical Engineering, Fall 2023 Syllabus SPOT
BMEN 5007.601, Research Methods in Biomedical Engineering, Fall 2023 SPOT
BMEN 2900.009, Special Problems in Biomedical Engineering, Fall 2023
BMEN 5900.003, Special Problems in Biomedical Engineering, Fall 2023
BMEN 5950.004, Master's Thesis, Summer 10W 2023
BMEN 5317.001, Advanced Biotechnology, Spring 2023 SPOT
BMEN 6950.008, Biomedical Engineering Doctoral Dissertation, Spring 2023
BMEN 6910.008, Individual Research, Spring 2023
BMEN 5950.008, Master's Thesis, Spring 2023
BMEN 2900.008, Special Problems in Biomedical Engineering, Spring 2023
BMEN 6950.010, Biomedical Engineering Doctoral Dissertation, Fall 2022
BMEN 4980.001, Experimental Course, Fall 2022 Syllabus SPOT
BMEN 6910.008, Individual Research, Fall 2022
BMEN 5950.003, Master's Thesis, Fall 2022
BMEN 5007.001, Research Methods in Biomedical Engineering, Fall 2022 SPOT
BMEN 2900.009, Special Problems in Biomedical Engineering, Fall 2022
BMEN 5900.003, Special Problems in Biomedical Engineering, Fall 2022
BMEN 5900.008, Special Problems in Biomedical Engineering, Summer 5W2 2022
BMEN 5317.001, Advanced Biotechnology, Spring 2022 SPOT
BMEN 6950.008, Biomedical Engineering Doctoral Dissertation, Spring 2022
BMEN 6910.008, Individual Research, Spring 2022
BMEN 5950.008, Master's Thesis, Spring 2022
BMEN 2900.008, Special Problems in Biomedical Engineering, Spring 2022
BMEN 4310.001, Biomedical Modeling, Fall 2021 Syllabus SPOT
BMEN 4310.301, Biomedical Modeling, Fall 2021 SPOT
BMEN 4310.302, Biomedical Modeling, Fall 2021 SPOT
BMEN 4310.303, Biomedical Modeling, Fall 2021 SPOT
BMEN 5315.001, Computational Methods in Biomedical Engineering, Fall 2021 Syllabus SPOT
BMEN 5315.301, Computational Methods in Biomedical Engineering, Fall 2021 SPOT
BMEN 5315.601, Computational Methods in Biomedical Engineering, Fall 2021 SPOT
BMEN 6910.008, Individual Research, Fall 2021
BMEN 5950.003, Master's Thesis, Fall 2021
BMEN 5900.003, Special Problems in Biomedical Engineering, Fall 2021
BMEN 5950.004, Master's Thesis, Summer 10W 2021
BMEN 5900.008, Special Problems in Biomedical Engineering, Summer 5W2 2021
BMEN 5317.001, Advanced Biotechnology, Spring 2021 SPOT
BMEN 5900.003, Special Problems in Biomedical Engineering, Spring 2021
BMEN 4310.001, Biomedical Modeling, Fall 2020 Syllabus SPOT
BMEN 4310.301, Biomedical Modeling, Fall 2020 SPOT
BMEN 4310.302, Biomedical Modeling, Fall 2020 SPOT
BMEN 5315.001, Computational Methods in Biomedical Engineering, Fall 2020 Syllabus SPOT
BMEN 5315.301, Computational Methods in Biomedical Engineering, Fall 2020 SPOT
BMEN 5315.601, Computational Methods in Biomedical Engineering, Fall 2020 Syllabus SPOT
BMEN 2900.003, Special Problems in Biomedical Engineering, Fall 2020
BMEN 5900.003, Special Problems in Biomedical Engineering, Fall 2020
BMEN 2900.004, Special Problems in Biomedical Engineering, Spring 2020
BMEN 5900.003, Special Problems in Biomedical Engineering, Spring 2020
BMEN 5800.002, Topics in Biomedical Engineering, Spring 2020 Syllabus
BMEN 5315.001, Computational Methods in Biomedical Engineering, Fall 2019 Syllabus SPOT
BMEN 5315.601, Computational Methods in Biomedical Engineering, Fall 2019 Syllabus SPOT
MTSE 6940.040, Individual Research, Fall 2019
MTSE 6940.041, Individual Research, Fall 2019

* Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.

Published Publications

Published Intellectual Contributions

Journal Article
Man, K., Liu, J., Liang, C., Corona, C., Story, M. D., Meckes, B. R., Yang, Y. (2023). Biomimetic human lung alveolar interstitium chip with extended longevity. Other. 15(30), 36888--36898. ACS Publications.
Wang, K., Man, K., Liu, J., Meckes, B. R., Yang, Y. (2023). Dissecting Physical and Biochemical Effects in Nanotopographical Regulation of Cell Behavior. ACS Nano. 17(3), 2124--2133. American Chemical Society.
Kohon, A. I., Man, K., Mathis, K., Webb, J., Yang, Y., Meckes, B. R. (2023). Nanoparticle targeting of mechanically modulated glycocalyx. Other. 10--1101. Cold Spring Harbor Laboratory.
Man, K., Liu, J., Liang, C., Corona, C., Story, M. D., Meckes, B. R., Yang, Y. (2022). Biomimetic Human Lung Alveolar Interstitium Chip with Extended Longevity. Cold Spring Harbor Laboratory. https://www.biorxiv.org/content/10.1101/2022.12.23.521822v1
Lin, M., Meckes, B. R., Chen, C., Teplensky, M. H., Mirkin, C. A. (2022). Controlling Intracellular Machinery via Polymer Pen Lithography Molecular Patterning. Other. 8(9), 1282-1289. American Chemical Society (ACS). http://dx.doi.org/10.1021/acscentsci.2c00683
Zhang, W., Callmann, C. E., Meckes, B. R., Mirkin, C. A. (2022). Tumor-Associated Enzyme-Activatable Spherical Nucleic Acids. ACS Nano. 16(7), 10931-10942. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsnano.2c03323
Oh, E., Meckes, B. R., Chang, J., Shin, D., Mirkin, C. A. (2021). Controlled Glioma Cell Migration and Confinement Using Biomimetic-Patterned Hydrogels. Other. 2100131. Wiley Online Library.
Ponedal, A., Zhu, S., Sprangers, A. J., Wang, X., Yeo, D. C., Lio, D. C., Zheng, M., Capek, M., Narayan, S. P., Meckes, B. R., Paller, A. S., Xu, C., Mirkin, C. A. (2020). Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1. Other. 3(12), 8603-8610. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsabm.0c00990
Chen, P., Liu, Y., Du, J. S., Meckes, B. R., Dravid, V. P., Mirkin, C. A. (2020). Chain-End Functionalized Polymers for the Controlled Synthesis of Sub-2 nm Particles. Journal of the American Chemical Society. 142(16), 7350-7355. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.0c02244
Zhang, W., Meckes, B. R., Mirkin, C. A. (2019). Spherical Nucleic Acids with Tailored and Active Protein Coronae. Other. 5(12), 1983-1990. https://doi.org/10.1021/acscentsci.9b01105
Cabezas, M. D., Meckes, B. R., Mirkin, C. A., Mrksich, M. (2019). Subcellular Control over Focal Adhesion Anisotropy, Independent of Cell Morphology, Dictates Stem Cell Fate. ACS Nano. https://doi.org/10.1021/acsnano.9b03937
Chen, P., Liu, M., Du, J. S., Meckes, B. R., Wang, S., Lin, H., Dravid, V. P., Wolverton, C., Mirkin, C. A. (2019). Interface and heterostructure design in polyelemental nanoparticles. Science. 363(6430), 959-964. American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/science.aav4302
Kluender, E. J., Hedrick, J. L., Brown, K. A., Rao, R., Meckes, B. R., Du, J. S., Moreau, L. M., Maruyama, B., Mirkin, C. A. (2019). Catalyst discovery through megalibraries of nanomaterials. Proceedings of the National Academy of Sciences. 116(1), 40-45. Proceedings of the National Academy of Sciences. http://dx.doi.org/10.1073/pnas.1815358116
Du, J. S., Chen, P., Meckes, B. R., Kluender, E. J., Xie, Z., Dravid, V. P., Mirkin, C. A. (2018). Windowless Observation of Evaporation-Induced Coarsening of Au–Pt Nanoparticles in Polymer Nanoreactors. Journal of the American Chemical Society. 140(23), 7213-7221. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.8b03105
Meckes, B. R., Banga, R. J., Nguyen, S. T., Mirkin, C. A. (2018). Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid-Tail DNA Modifications. Small. 14(5), 1702909. Wiley. http://dx.doi.org/10.1002/smll.201702909
Xie, Z., Gordiichuk, P., Lin, Q., Meckes, B. R., Chen, P., Sun, L., Du, J. S., Zhu, J., Liu, Y., Dravid, V. P., Mirkin, C. A. (2017). Solution-Phase Photochemical Nanopatterning Enabled by High-Refractive-Index Beam Pen Arrays. ACS Nano. 11(8), 8231-8241. American Chemical Society (ACS). http://dx.doi.org/10.1021/acsnano.7b03282
Chen, P., Du, J. S., Meckes, B. R., Huang, L., Xie, Z., Hedrick, J. L., Dravid, V. P., Mirkin, C. A. (2017). Structural Evolution of Three-Component Nanoparticles in Polymer Nanoreactors. Journal of the American Chemical Society. 139(29), 9876-9884. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.7b03163
Du, J. S., Chen, P., Meckes, B. R., Xie, Z., Zhu, J., Liu, Y., Dravid, V. P., Mirkin, C. A. (2017). The Structural Fate of Individual Multicomponent Metal-Oxide Nanoparticles in Polymer Nanoreactors. Angewandte Chemie International Edition. 56(26), 7625-7629. Wiley. http://dx.doi.org/10.1002/anie.201703296
Du, J. S., Chen, P., Meckes, B. R., Xie, Z., Zhu, J., Liu, Y., Dravid, V. P., Mirkin, C. A. (2017). The Structural Fate of Individual Multicomponent Metal-Oxide Nanoparticles in Polymer Nanoreactors. Other. 129(26), 7733-7737. Wiley. http://dx.doi.org/10.1002/ange.201703296
Banga, R. J., Meckes, B. R., Narayan, S. P., Sprangers, A. J., Nguyen, S. T., Mirkin, C. A. (2017). Cross-Linked Micellar Spherical Nucleic Acids from Thermoresponsive Templates. Journal of the American Chemical Society. 139(12), 4278-4281. American Chemical Society (ACS). http://dx.doi.org/10.1021/jacs.6b13359
Hwang, M. T., Landon, P. B., Lee, J., Mo, A., Meckes, B. R., Glinsky, G., Lal, R. (2015). DNA nano-carrier for repeatable capture and release of biomolecules. Nanoscale. 7(41), 17397-17403. Royal Society of Chemistry (RSC). http://dx.doi.org/10.1039/c5nr05124j
Meckes, B. R., Arce, F. T., Connelly, L. S., Lal, R. (2015). Insulated Conducting Cantilevered Nanotips and Two-Chamber Recording System for High Resolution Ion Sensing AFM. Scientific Reports. 4(1), . Springer Science and Business Media LLC. http://dx.doi.org/10.1038/srep04454
Meckes, B. R., Ambrosi, C., Barnard, H., Arce, F. T., Sosinsky, G. E., Lal, R. (2014). Atomic Force Microscopy Shows Connexin26 Hemichannel Clustering in Purified Membrane Fragments. Biochemistry. 53(47), 7407-7414. American Chemical Society (ACS). http://dx.doi.org/10.1021/bi501265p
Kwok, J., Grogan, S., Meckes, B. R., Arce, F., Lal, R., D’Lima, D. (2014). Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. Other. 10(8), 1777-1785. Elsevier BV. http://dx.doi.org/10.1016/j.nano.2014.06.010
Landon, P. B., Lee, J., Hwang, M. T., Mo, A. H., Zhang, C., Neuberger, A., Meckes, B. R., Gutierrez, J. J., Glinsky, G., Lal, R. (2014). Energetically Biased DNA Motor Containing a Thermodynamically Stable Partial Strand Displacement State. Langmuir. 30(46), 14073-14078. American Chemical Society (ACS). http://dx.doi.org/10.1021/la503711g
Alfonta, L., Meckes, B. R., Amir, L., Schlesinger, O., Ramachandran, S., Lal, R. (2014). Measuring Localized Redox Enzyme Electron Transfer in a Live Cell with Conducting Atomic Force Microscopy. Analytical Chemistry. 86(15), 7674-7680. American Chemical Society (ACS). http://dx.doi.org/10.1021/ac5015645
Connelly, L. S., Meckes, B. R., Larkin, J., Gillman, A. L., Wanunu, M., Lal, R. (2014). Graphene Nanopore Support System for Simultaneous High-Resolution AFM Imaging and Conductance Measurements. ACS Applied Materials & Interfaces. 6(7), 5290-5296. American Chemical Society (ACS). http://dx.doi.org/10.1021/am500639q
Mo, A. H., Landon, P. B., Meckes, B. R., Yang, M. M., Glinsky, G. V., Lal, R. (2013). An on-demand four-way junction DNAzyme nanoswitch driven by inosine-based partial strand displacement. Nanoscale. 6(3), 1462-1466. Royal Society of Chemistry (RSC). http://dx.doi.org/10.1039/c3nr05365b
Arce, F. T., Meckes, B. R., Camp, S. M., Garcia, J. G., Dudek, S. M., Lal, R. (2013). Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Other. 9(7), 875-884. Elsevier BV. http://dx.doi.org/10.1016/j.nano.2013.03.006
Leiske, D. L., Meckes, B. R., Miller, C. E., Wu, C., Walker, T. W., Lin, B., Meron, M., Ketelson, H. A., Toney, M. F., Fuller, G. G. (2011). Insertion Mechanism of a Poly(ethylene oxide)-poly(butylene oxide) Block Copolymer into a DPPC Monolayer. Langmuir. 27(18), 11444-11450. American Chemical Society (ACS). http://dx.doi.org/10.1021/la2016879
Proceedings
Montoya, B., Mittal, I., Scofield, S., Shah, J., Meckes, B. (2022). Spherical Nucleic Acids for Fusarium graminearum gene regulatio. Other. Minneapolis, Minnesota: US Wheat and Barley Scab Initiative.
Montoya, B., Mittal, I., Shah, J., Meckes, B. (2021). Development of Biocompatible siRNA Nanoparticles to Mitigate FHB in Wheat. Other. 50. US Wheat and Barley Scab Initiative. https://scabusa.org/forum/2021/2021NFHBForumProceedings.pdf

Awarded Grants

Contracts, Grants and Sponsored Research

Fellowship
Meckes, B., "Scanning Ion Conductance Microscope-array for the Study of Ion Channel Clusters," Sponsored by NIH/NIDA, Federal, $103000 Funded. (January 14, 2013October 1, 2015).
Grant - Research
Meckes, B. R. (Principal), Yang, Y. (Co-Principal), "Lipidomics of Lung Fibrosis for Therapeutic Targeting," Sponsored by University of North Texas, University of North Texas, $3000 Funded. (June 1, 2023 – Present).
Meckes, B. R., "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces," Sponsored by NIH/NIGMS, Federal, $1798070 Funded. (September 1, 2023July 31, 2028).
Shah, J. (Principal), Meckes, B. (Co-Principal), "Spherical nucleic acid nanomaterials as fungicide and FHB resistance-promoting agents," Sponsored by Agricultural Research Service, Federal, $115942 Funded. (August 1, 2022July 31, 2024).
Meckes, B., "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding," Sponsored by NIH/NIGMS, Federal, $383151 Funded. (September 1, 2021August 31, 2023).
Meckes, B. (Principal), Li, L. (Principal), "Nanoparticles for Blood Brain Barrier Delivery," Sponsored by University of North Texas, University of North Texas, $10000 Funded. (February 7, 2022February 28, 2023).
Meckes, B. (Principal), "Ralph Powe Junior Faculty Enhancement," Sponsored by ORAU, Private, $10000 Funded. (June 1, 2021May 31, 2022).
Meckes, B. (Co-Principal), Shah, J. (Co-Principal), "Plant Exosome Mimics for Gene Regulation in Fungal Species Affecting Crops," Sponsored by COS-CENG, University of North Texas, $10000 Funded. (June 16, 2021March 15, 2021).
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Overall
Summative Rating
Challenge and
Engagement Index
Response Rate

out of 5

out of 7
%
of
students responded
  • Overall Summative Rating (median):
    This rating represents the combined responses of students to the four global summative items and is presented to provide an overall index of the class’s quality. Overall summative statements include the following (response options include a Likert scale ranging from 5 = Excellent, 3 = Good, and 1= Very poor):
    • The course as a whole was
    • The course content was
    • The instructor’s contribution to the course was
    • The instructor’s effectiveness in teaching the subject matter was
  • Challenge and Engagement Index:
    This rating combines student responses to several SPOT items relating to how academically challenging students found the course to be and how engaged they were. Challenge and Engagement Index items include the following (response options include a Likert scale ranging from 7 = Much higher, 4 = Average, and 1 = Much lower):
    • Do you expect your grade in this course to be
    • The intellectual challenge presented was
    • The amount of effort you put into this course was
    • The amount of effort to succeed in this course was
    • Your involvement in course (doing assignments, attending classes, etc.) was
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