Huaxiao Yang

Previous Scheduled Teaching

Published Intellectual Contributions

Conference Proceeding

• Medisetti, G., Compson, Z.G., Fan, H., Yang, H., Feng, Y. (2024). LitAI: Enhancing Multimodal Literature Understanding and Mining with Generative AI. 471-476. San Jose, CA, 2024 IEEE 7th International Conference on Multimedia Information Processing and Retrieval (MIPR).
• Jahed, Z., Yang, Y., Yang, H., McGuire, A., Liu, A., Li, X., Cui, B. (2020). Developing Nanoelectrodes into Robust Electrophysiological Tools for Accurate and Parallel Recording of Action Potentials from Single Cells. Biophysical Journal. 118 (3) 28A-28A.
• Wu, H., Yang, H., Rhee, J., Zhang, J., Lam, C.K., Sallam, K., Chang, A.C., Ma, N., Blau, H., Bers, D., Wu, J. (2018). Modeling of Diastolic Dysfunction in Induced Pluripotent Stem Cell-derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients. Circulation Research. 123
• Wu, H., Yang, H., Zhang, J., Lam, C.K., Rhee, J., Seeger, T., Sallam, K., Ma, N., Wu, J. (2017). Restoration of Impaired Diastolic Function in Hypertrophic Cardiomyopathy Induced Pluripotent Stem Cell-derived Cardiomyocytes by Re-balancing the Calcium Homeostasis. Circulation Research. 121
• Qin, X., Chen, H., Li, K., Yang, H., Wu, H., Zhao, X., Daldrup-Link, H., Wu, J.C. (2017). Tracking Human Pluripotent Stem Cell-Derived Cardiomyocytes in Post-Myocardial Infarction Heart with Photoacoustic Imaging. Circulation Research. 121
• Wu, H., Yang, H., Seeger, T., Lam, C.K., Zhang, J.Z., Wu, J.C. (2016). Restoration of Impaired Diastolic Function in Induced Pluripotent Stem Cell Derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients by Re-Balancing the Calcium Homeostasis. Circulation. 134
• Zhao, M., Chen, H., Liu, Q., Sayed, N., Shao, N., Kim, Y., Yang, H., Chour, T., Ma, H., Tippner-Hedges, R., Mitalipov, S., Snyder, M., Wu, J. (2016). Transcriptomic and Epigenomic Resemblance of Terminally Differentiated Cells Derived From Isogenic Human iPSCs and Nuclear Transfer Derived ESCs. Circulation. 134
• Zhao, M., Chen, H., Liu, Q., Sayed, N., Shao, N., Kim, Y., Yang, H., Chour, T., Ma, H., Tippner-Hedges, R., Mitalipov, S., Snyder, M., Wu, J. (2016). Transcriptomic and Epigenomic Resemblance of Terminally Differentiated Cells Derived From Isogenic Human iPSCs and Nuclear Transfer Derived ESCs. Circulation. 134
• Yang, H., Runyan, R.B., Borg, T.K., Markwald, R., Xu, M., Gao, B.Z. (2014). Myocardial Rescue by Mesenchymal Stem Cell via Tunneling Nanotube Formation. Circulation. 130

Journal Article

• Liu, C., Shen, M., Liu, Y., Manhas, A., Zhao, S.R., Zhang, M., Belbachir, N., Ren, L., Zhang, J.Z., Caudal, A., Nishiga, M., Thomas, D., Zhang, A., Yang, H., Zhou, Y., Ameen, M., Sayed, N., Rhee, J., Qi, L.S., Wu, J.C. (2024). CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity. Other. 31 (12) 1760-1776.e9. Elsevier BV. https://doi.org/10.1016/j.stem.2024.10.007
• Yang, Y., Valencia, L.A., Lu, C., Nakamoto, M.L., Tsai, C., Liu, C., Yang, H., Zhang, W., Jahed, Z., Lee, W., Santoro, F., Liou, J., Wu, J.C., Cui, B. (2024). Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum. Other. 26 (11) 1878-1891. Springer Science and Business Media LLC. https://doi.org/10.1038/s41556-024-01511-x
• Kandula AKR, Phamornratanakun, T., Gomez, A.H., El-Mokahal, M., Ma, Z., Feng, Y., Yang, H. (2024). Generative AI for Cell Type-Specific Fluorescence Image Generation of hPSC-derived Cardiac Organoid.. Other.
• Medisetti, G., Compson, Z.G., Fan, H., Yang, H., Feng, Y. (2024). LitAI: Enhancing Multimodal Literature Understanding and Mining with Generative AI.. Other. 2024 471-476.
• Wen, Y., Yang, H., Hong, Y. (2024). Transcriptomic Approaches to Cardiomyocyte-Biomaterial Interactions: A Review.. ACS Biomaterials Science & Engineering. 10 (7) 4175-4194.
• Kowalczewski, A., Sun, S., Mai, N.Y., Song, Y., Hoang, P., Liu, X., Yang, H., Ma, Z. (2024). Design optimization of geometrically confined cardiac organoids enabled by machine learning techniques.. Other. 4 (6) 100798.
• Taylor, A., Xu, J., Rogozinski, N., Fu, H., Molina Cortez, L., McMahan, S., Chang, Y., Pan, Z., Yang, H., Liao, J., Hong, Y. (2024). Reduced Graphene-Oxide-Doped Elastic Biodegradable Polyurethane Fibers for Cardiomyocyte Maturation.. ACS Biomaterials Science & Engineering. 10 (6) 3759-3774.
• Shi, H., Kowalczewski, A., Vu, D., Liu, X., Salekin, A., Yang, H., Ma, Z. (2024). Organoid intelligence: Integration of organoid technology and artificial intelligence in the new era of in vitro models.. Other. 21
• Fouladgar, F., Moslabeh, F.G., Kasani, Y.V., Rogozinski, N., Torres, M., Ecker, M.J., Yang, H., Yang, Y., Habibi, N. (2024). Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels. Other. 10 (1) e23953. https://www.sciencedirect.com/science/article/pii/S2405844023111613
• Maramraju, S., Kowalczewski, A., Kaza, A., Liu, X., Singaraju, J.P., Albert, M.V., Ma, Z., Yang, H. (2024). AI-organoid integrated systems for biomedical studies and applications.. Other. 9 (2) e10641.
• Singaraju, J.P., Kadiresan, A., Bhoi, R.K., Gomez, A.H., Ma, Z., Yang, H. (2023). Organalysis: Multifunctional Image Preprocessing and Analysis Software for Cardiac Organoid Studies.. Other. 29 (12) 572-582.
• Tu, C., Caudal, A., Liu, Y., Gorgodze, N., Zhang, H., Lam, C.K., Dai, Y., Zhang, A., Wnorowski, A., Wu, M.A., Yang, H., Abilez, O.J., Lyu, X., Narayan, S.M., Mestroni, L., Taylor MRG, Recchia, F.A., Wu, J.C. (2023). Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction.. Other.
• Liu, C., Shen, M., Tan WLW, Chen, I.Y., Liu, Y., Yu, X., Yang, H., Zhang, A., Liu, Y., Zhao, M.T., Ameen, M., Zhang, M., Gross, E.R., Qi, L.S., Sayed, N., Wu, J.C. (2023). Statins improve endothelial function via suppression of epigenetic-driven EndMT.. Other. 2 (5) 467-485.
• Rogozinski, N., Yanez, A., Bhoi, R., Lee, M., Yang, H. (2022). Current methods for fabricating 3D cardiac engineered constructs. iScience.
• Strimaityte, D., Tu, C., Yanez, A., Itzhaki, I., Wu, H., Wu, J.C., Yang, H. (2022). Contractility and Calcium Transient Maturation in the Human iPSC-Derived Cardiac Microfibers.. ACS Applied Materials & Interfaces. 14 (31) 35376-35388.
• Wang, J., Soto, F., Ma, P., Ahmed, R., Yang, H., Chen, S., Wang, J., Liu, C., Akin, D., Fu, K., Cao, X., Chen, P., Hsu, E.C., Soh, H.T., Stoyanova, T., Wu, J.C., Demirci, U. (2022). Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots.. ACS Nano. 16 (7) 10219-10230.
• Jahed, Z., Yang, Y., Tsai, C.T., Foster, E.P., McGuire, A.F., Yang, H., Liu, A., Forro, C., Yan, Z., Jiang, X., Zhao, M.T., Zhang, W., Li , X., Li , T., Pawlosky, A., Wu, J.C., Cui, B. (2022). Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes.. Nature Communications. 13 (1) 2253.
• Gomez, A.H., Joshi, S., Yang, Y., Tune, J.D., Zhao, M., Yang, H. (2021). Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration. Journal of Cardiovascular Development and Disease. 8 (10) 125. MDPI.
• Gomez, A.H., Joshi, S., Yang, Y., Tune, J.D., Zhao, M.T., Yang, H. (2021). Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration.. Journal of Cardiovascular Development and Disease. 8 (10)
• Yang, H., Shao, N., Holmström, A., Zhao, X., Chour, T., Chen, H., Itzhaki, I., Wu, H., Ameen, M., Cunningham, N.J., Tu, C., Zhao, M.T., Tarantal, A.F., Abilez, O.J., Wu, J.C. (2021). Transcriptome analysis of non human primate-induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer culture vs. 3D engineered heart tissue.. Other. 117 (9) 2125-2136.
• Chen, H., Yang, H., Zhang, C., Chen, S., Zhao, X., Zhu, M., Wang, Z., Wang, Y., Wo, H.T., Li , K., Cheng, Z. (2021). Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker.. Other. 2021 9798580.
• Joshi, S., Lee, W.H., Chen, P., Serpooshan, V., Yang, H. (2021). Editorial: 3D Cell Culture Systems for Cardiovascular Tissue Engineering: In vitro Modelling and in vivo Regenerative Therapies.. Other. 8 675676.
• Wilson, K.D., Ameen, M., Guo, H., Abilez, O.J., Tian, L., Mumbach, M.R., Diecke, S., Qin, X., Liu, Y., Yang, H., Ma, N., Gaddam, S., Cunningham, N.J., Gu, M., Neofytou, E., Prado, M., Hildebrandt, T.B., Karakikes, I., Chang, H.Y., Wu, J.C. (2020). Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Developmental Cell. 54 (6) 694-+.
• Lee, S., Yang, H., Chen, C., Venkatraman, S., Darsha, A., Wu, S.M., Wu, J.C., Seeger, T. (2020). Simple Lithography-Free Single Cell Micropatterning using Laser-Cut Stencils. Other. (158)
• Seeger, T., Shrestha, R., Lam, C.K., Chen, C., McKeithan, W.L., Lau, E., Wnorowski, A., McMullen, G., Greenhaw, M., Lee, J., Oikonomopoulos, A., Lee, S., Yang, H., Mercola, M., Wheeler, M., Ashley, E.A., Yang, F., Karakikes, I., Wu, J.C. (2019). A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 139 (6) 799-811.
• Yang, H., Qin, X., Wang, H., Zhao, X., Liu, Y., Wo, H., Liu, C., Nishiga, M., Chen, H., Ge, J., Sayed, N., Abilez, O.J., Ding, D., Heilshorn, S.C., Li, K. (2019). An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium. ACS Nano. 13 (9) 9880-9894.
• Wu, H., Yang, H., Rhee, J., Zhang, J.Z., Lam, C.K., Sallam, K., Chang, Alex C. Y., Ma, N., Lee, J., Zhang, H., Blau, H.M., Bers, D.M., Wu, J.C. (2019). Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Other. 40 (45) 3685-+.
• Wnorowski, A., Yang, H., Wu, J.C. (2019). Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models. Other. 140 3-11.
• Zhao, X., Chen, H., Xiao, D., Yang, H., Itzhaki, I., Qin, X., Chour, T., Aguirre, A., Lehmann, K., Kim, Y., Shukla, P., Holmstrom, A., Zhang, J.Z., Yan Zhuge, Ndoye, B.C., Zhao, M., Neofytou, E., Zimmermann, W., Jain, M., Wu, J.C. (2018). Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Other. 10 (2) 422-435.
• Abilez, O.J., Tzatzalos, E., Yang, H., Zhao, M., Jung, G., Zollner, A.M., Tiburcy, M., Riegler, J., Matsa, E., Shukla, P., Yan Zhuge, Chour, T., Chen, V.C., Burridge, P.W., Karakikes, I., Kuhl, E., Bernstein, D., Couture, L.A., Gold, J.D., Zimmermann, W.H., Wu, J.C. (2018). Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling. Other. 36 (2) 265-277.
• Qin, X., Chen, H., Yang, H., Wu, H., Zhao, X., Wang, H., Chour, T., Neofytou, E., Ding, D., Daldrup-Link, H., Heilshorn, S.C., Li, K., Wu, J.C. (2018). Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles. Advanced Functional Materials. 28 (1)
• Zhao, M., Chen, H., Liu, Q., Shao, N., Sayed, N., Wo, H., Zhang, J.Z., Ong, S., Liu, C., Kim, Y., Yang, H., Chour, T., Ma, H., Gutierrez, N.M., Karakikes, I., Mitalipov, S., Snyder, M.P., Wu, J.C. (2017). Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proceedings of the National Academy of Sciences of the United States of America. 114 (52) E11111-E11120.
• Yang, H., Borg, T.K., Ma, Z., Xu, M., Wetzel, G., Saraf, L.V., Markwald, R., Runyan, R.B., Gao, B.Z. (2016). Biochip-based study of unidirectional mitochondrial transfer from stem cells to myocytes via tunneling nanotubes. Biofabrication. 8 (1)
• Yang, H., Schmidt, L.P., Wang, Z., Yang, X., Shao, Y., Borg, T.K., Markwald, R., Runyan, R., Gao, B.Z. (2016). Dynamic Myofibrillar Remodeling in Live Cardiomyocytes under Static Stretch. Scientific Reports. 6
• Yang, H., Borg, T.K., Liu, H., Gao, B.Z. (2015). Interactive relationship between basement-membrane development and sarcomerogenesis in single cardiomyocytes. Other. 330 (1) 222-232.
• Liu, H., Chen, R., Yang, H., Qin, W., Borg, T.K., Dean, D., Xu, M., Gao, B.Z. (2014). Enzyme-etching technique to fabricate micropatterns of aligned collagen fibrils. Other. 36 (6) 1245-1252.
• Yang, H., Borg, T.K., Schmidt, L.P., Gao, B.Z. (2014). Laser cell-micropatterned pair of cardiomyocytes: the relationship between basement membrane development and gap junction maturation. Biofabrication. 6 (4)
• Yang, H., Borg, T.K., Wang, Z., Ma, Z., Gao, B.Z. (2014). Role of the Basement Membrane in Regulation of Cardiac Electrical Properties. Annals of Biomedical Engineering. 42 (6) 1148-1157.
• Ma, Z., Liu, Q., Yang, H., Runyan, R.B., Eisenberg, C.A., Xu, M., Borg, T.K., Markwald, R., Wang, Y., Gao, B.Z. (2013). Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level. Other. 2
• Ma, Z., Yang, H., Liu, H., Xu, M., Runyan, R.B., Eisenberg, C.A., Markwald, R.R., Borg, T.K., Gao, B.Z. (2013). Mesenchymal Stem Cell-Cardiomyocyte Interactions under Defined Contact Modes on Laser-Patterned Biochips. PLOS One. 8 (2)
• Ma, Z., Liu, Q., Liu, H., Yang, H., Yun, J.X., Xu, M., Eisenberg, C.A., Borg, T.K., Markwald, R., Gao, B.Z. (2012). Cardiogenic Regulation of Stem-Cell Electrical Properties in a Laser-Patterned Biochip. Other. 5 (3) 327-336.
• Ma, Z., Liu, Q., Liu, H., Yang, H., Yun, J.X., Eisenberg, C., Borg, T.K., Xu, M., Gao, B.Z. (2012). Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Other. 12 (3) 566-573.
• Yang, H., Ma, Z. (2012). Microsystem for Stem Cell-Based Cardiovascular Research. Other. 2 (4) 305-315.
• Sun Min, Yang Huaxiao, Zhou Ping, Pan Luanfeng, Liu Shui. (2010). BIOCOMPATIBILITY OF PHBHHx AND SILK FIBROIN-MODIFIED PHBHHx SCAFFOLDS WITH HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. Other. (12) 1430-1436.
• Yang, H., Sun, M., Zhou, P. (2009). Investigation of water diffusion in poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by generalized two-dimensional correlation ATR-FTIR spectroscopy. Polymer. 50 (6) 1533-1540.

Contracts, Grants and Sponsored Research

Contract

• Yang, H. (Principal), "LOI-HFpEF in a Dish: Establishing a Human in vitro Model," sponsored by AHA, National, Funded. (2024 - 2027).

Fellowship

• Yang, H., "Interrogating the Cardiovascular Toxicity of Volatile Organic Compounds from E-Cigarettes in hiPSC-derived Vascularized Cardiac Organoids," sponsored by American Heart Association (AHA), National, $155716 Funded. (2018 - 2020).
• Yang, H., "Interrogating the Cardiovascular Toxicity of Volatile Organic Compounds from E-Cigarettes in hiPSC-derived Vascularized Cardiac Organoids," sponsored by American Heart Association (AHA), National, Funded. (2018 - 2020).

Grant - Research

• Yang, H. (Principal), "NIH R56 Bridge Funding," sponsored by NIH, Federal, $547020 Funded. (2024 - 2025).
• Yang, H. (Principal), "NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoids," sponsored by NIH, Federal, $444874 Funded. (2022 - 2025).
• Yang, H. (Principal), "Prototyping the Human Cardiac Fibrosis by Interfacing the 3D Bioprinting and Clinical Diagnosis for Early Detection of Cardiac Arrhythmogenicity," sponsored by Harry Moss Heart/BOA Trust, Private, $75000 Funded. (2023 - 2024).
• Yang, H., Tune, J., Albert, M., "Clinical trial in a dish for studying antihypertensive drug induced cardiovascular malformation and dysfunction in gestational hypertension," sponsored by University of North Texas, University of North Texas, $7800 Funded. (2021 - 2022).