Faculty Profile

Douglas Root

Title
Associate Professor
Department
Biological Sciences
College
College of Science

    

    

      


                          

            
Curriculum Vitae

            

              Click Here to View Faculty CV
            

          

        
                          

            
Education

            



  

  


  
PhD, UCLA, 1992. 
Major: Molecular Biology/"Structural Determinants of Actomyosin Interactions and Protein Quantification by Copper Iodide Staining."
BS, University of California, Irvine, 1985. 
Major: Biological Sciences





          

        
                

          
Current Scheduled Teaching*


          
BIOC 6940.705, Individual Research, Fall 2023 
BIOC 5950.705, Master's Thesis, Fall 2023 
BIOC 6630.001, Protein Structure and Function, Fall 2023 Syllabus
BIOC 4900.705, Special Problems, Fall 2023 


          
*
  Texas Education Code 51.974 (HB 2504) requires each institution of
  higher education to make available to the public, a syllabus for
  undergraduate lecture courses offered for credit by the institution.
  

        

      

    

  


    

    

      


        


          


            
Previous Scheduled Teaching*


            
                    

                    BIOC 6950.705, Doctoral Dissertation, Summer 5W1 2023 
                    

                    BIOL 4900.705, Special Problems, Summer 5W2 2023 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2023 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2023 Syllabus SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2023 
                    

                    BIOC 4900.705, Special Problems, Spring 2023 
                    

                    BIOL 4900.705, Special Problems, Spring 2023 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2022 Syllabus SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2022 
                    

                    BIOL 6940.705, Individual Research, Fall 2022 
                    

                    BIOC 4900.705, Special Problems, Fall 2022 
                    

                    BIOC 5950.705, Master's Thesis, Summer 5W2 2022 
                    

                    BIOC 5950.705, Master's Thesis, Summer 5W1 2022 
                    

                    BIOC 4900.705, Special Problems, Summer 10W 2022 
                    

                    BIOC 5900.705, Special Problems, Summer 5W2 2022 
                    

                    BIOC 5910.705, Special Problems, Summer 5W2 2022 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2022 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2022 Syllabus SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2022 
                    

                    BIOC 6940.705, Individual Research, Spring 2022 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2021 
                    

                    BIOC 6940.705, Individual Research, Fall 2021 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2021 Syllabus SPOT
                    

                    BIOC 4900.705, Special Problems, Fall 2021 
                    

                    BIOC 6900.705, Special Problems, Fall 2021 
                    

                    BIOC 4900.705, Special Problems, Summer 10W 2021 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2021 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2021 Syllabus SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2021 
                    

                    BIOC 6940.705, Individual Research, Spring 2021 
                    

                    BIOC 4900.705, Special Problems, Spring 2021 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2020 Syllabus SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2020 
                    

                    BIOL 4951.705, Honors College Capstone Thesis, Fall 2020 
                    

                    BIOC 6940.705, Individual Research, Fall 2020 
                    

                    BIOL 4900.705, Special Problems, Fall 2020 
                    

                    BIOC 6950.705, Doctoral Dissertation, Summer 5W2 2020 
                    

                    BIOC 4900.705, Special Problems, Summer 5W2 2020 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2020 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2020 Syllabus
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2020 
                    

                    BIOC 6940.705, Individual Research, Spring 2020 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2019 
                    

                    BIOC 6940.705, Individual Research, Fall 2019 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2019 Syllabus SPOT
                    

                    BIOL 4900.705, Special Problems, Fall 2019 
                    

                    BIOC 4900.705, Special Problems, Summer 10W 2019 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2019 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2019  SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2019 
                    

                    BIOC 6940.705, Individual Research, Spring 2019 
                    

                    BIOC 5900.705, Special Problems, Spring 2019 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2018  SPOT
                    

                    BIOL 6200.791, Bioinstrumentation and Analytical Techniques, Fall 2018  SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2018 
                    

                    BIOC 6940.705, Individual Research, Fall 2018 
                    

                    BIOC 5900.705, Special Problems, Fall 2018 
                    

                    BIOL 4900.705, Special Problems, Fall 2018 
                    

                    BIOC 4900.705, Special Problems, Summer 10W 2018 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2018 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2018 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2018  SPOT
                    

                    BIOC 5550.791, Biochemistry II, Spring 2018  SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2018 
                    

                    BIOC 6940.705, Individual Research, Spring 2018 
                    

                    BIOL 6940.705, Individual Research, Spring 2018 
                    

                    BIOC 5900.705, Special Problems, Spring 2018 
                    

                    BIOL 4900.705, Special Problems, Spring 2018 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2017 
                    

                    BIOC 6940.705, Individual Research, Fall 2017 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2017  SPOT
                    

                    BIOC 5900.705, Special Problems, Fall 2017 
                    

                    BIOC 6950.705, Doctoral Dissertation, Summer 10W 2017 
                    

                    BIOC 4900.705, Special Problems, Summer 5W1 2017 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2017 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2017 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2017  SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2017 
                    

                    BIOC 3996.001, Honors College Mentored Research Experience, Spring 2017 
                    

                    BIOC 6940.705, Individual Research, Spring 2017 
                    

                    BIOC 4900.705, Special Problems, Spring 2017 
                    

                    BIOL 4900.705, Special Problems, Spring 2017 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2016  SPOT
                    

                    BIOL 6200.791, Bioinstrumentation and Analytical Techniques, Fall 2016  SPOT
                    

                    BIOL 6950.705, Doctoral Dissertation, Fall 2016 
                    

                    BIOC 6940.705, Individual Research, Fall 2016 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2016 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2016 Syllabus SPOT
                    

                    BIOC 5550.001, Biochemistry II, Spring 2016  SPOT
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2016 
                    

                    BIOL 6950.705, Doctoral Dissertation, Spring 2016 
                    

                    BIOC 6940.705, Individual Research, Spring 2016 
                    

                    BIOC 6900.705, Special Problems, Spring 2016 
                    

                    BIOL 4900.705, Special Problems, Spring 2016 
                    

                    BIOL 6950.705, Doctoral Dissertation, Fall 2015 
                    

                    BIOC 6940.705, Individual Research, Fall 2015 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2015  SPOT
                    

                    BIOC 6900.705, Special Problems, Fall 2015 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2015 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2015 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2015 
                    

                    BIOL 6950.705, Doctoral Dissertation, Spring 2015 
                    

                    BIOC 6940.705, Individual Research, Spring 2015 
                    

                    BIOC 6900.705, Special Problems, Spring 2015 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2014 
                    

                    BIOL 6950.705, Doctoral Dissertation, Fall 2014 
                    

                    BIOC 6940.705, Individual Research, Fall 2014 
                    

                    BIOC 6900.705, Special Problems, Fall 2014 
                    

                    BIOC 6910.705, Special Problems, Fall 2014 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2014 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2014 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2014 
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2014 
                    

                    BIOC 6940.705, Individual Research, Spring 2014 
                    

                    BIOC 4900.705, Special Problems, Spring 2014 
                    

                    BIOL 4900.705, Special Problems, Spring 2014 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2013 
                    

                    BIOC 6940.705, Individual Research, Fall 2013 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2013 
                    

                    BIOC 4900.705, Special Problems, Fall 2013 
                    

                    BIOC 6910.705, Special Problems, Fall 2013 
                    

                    BIOL 4900.705, Special Problems, Fall 2013 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2013 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2013 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2013 
                    

                    BIOC 6940.705, Individual Research, Spring 2013 
                    

                    BIOC 5950.705, Master's Thesis, Spring 2013 
                    

                    BIOL 4900.705, Special Problems, Spring 2013 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2012 
                    

                    BIOC 6940.705, Individual Research, Fall 2012 
                    

                    BIOL 6940.705, Individual Research, Fall 2012 
                    

                    BIOC 4900.705, Special Problems, Fall 2012 
                    

                    BIOC 5900.705, Special Problems, Fall 2012 
                    

                    BIOL 4900.705, Special Problems, Fall 2012 
                    

                    BIOL 4910.705, Special Problems, Fall 2012 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2012 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2012 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2012 
                    

                    BIOC 6940.705, Individual Research, Spring 2012 
                    

                    BIOC 5900.705, Special Problems, Spring 2012 
                    

                    BIOC 5910.705, Special Problems, Spring 2012 
                    

                    BIOL 4900.705, Special Problems, Spring 2012 
                    

                    BIOC 5950.705, Master's Thesis, Fall 2011 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2011 
                    

                    BIOC 5900.705, Special Problems, Fall 2011 
                    

                    BIOC 6900.705, Special Problems, Fall 2011 
                    

                    BIOC 6910.705, Special Problems, Fall 2011 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2011 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2011 Syllabus
                    

                    BIOC 5550.001, Biochemistry II, Spring 2011 
                    

                    BIOC 6940.705, Individual Research, Spring 2011 
                    

                    BIOC 5950.705, Master's Thesis, Spring 2011 
                    

                    BIOC 5900.705, Special Problems, Spring 2011 
                    

                    BIOC 6900.705, Special Problems, Spring 2011 
                    

                    BIOC 6910.705, Special Problems, Spring 2011 
                    

                    BIOL 4900.705, Special Problems, Spring 2011 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2010 
                    

                    BIOC 5950.705, Master's Thesis, Fall 2010 
                    

                    BIOC 4900.705, Special Problems, Fall 2010 
                    

                    BIOC 6900.705, Special Problems, Fall 2010 
                    

                    BIOC 6910.705, Special Problems, Fall 2010 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2010 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2010 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2010 
                    

                    BIOC 5950.705, Master's Thesis, Spring 2010 
                    

                    BIOC 5900.705, Special Problems, Spring 2010 
                    

                    BIOC 6900.705, Special Problems, Spring 2010 
                    

                    BIOC 6910.705, Special Problems, Spring 2010 
                    

                    BIOL 4900.705, Special Problems, Spring 2010 
                    

                    BIOC 5950.705, Master's Thesis, Fall 2009 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2009 
                    

                    BIOC 5900.705, Special Problems, Fall 2009 
                    

                    BIOL 4900.705, Special Problems, Fall 2009 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2009 
                    

                    BIOL 4900.705, Special Problems, Summer 5W2 2009 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2009 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2009 
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2009 
                    

                    BIOC 5950.705, Master's Thesis, Spring 2009 
                    

                    BIOC 5900.705, Special Problems, Spring 2009 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2008 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2008 
                    

                    BIOC 6940.705, Individual Research, Fall 2008 
                    

                    BIOC 5900.705, Special Problems, Fall 2008 
                    

                    BIOC 5910.705, Special Problems, Fall 2008 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2008 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2008 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2008 
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2008 
                    

                    BIOC 6940.705, Individual Research, Spring 2008 
                    

                    BIOC 4900.705, Special Problems, Spring 2008 
                    

                    BIOC 5900.705, Special Problems, Spring 2008 
                    

                    BIOL 4900.705, Special Problems, Spring 2008 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2007 
                    

                    BIOC 6940.705, Individual Research, Fall 2007 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2007 
                    

                    BIOC 5900.705, Special Problems, Fall 2007 
                    

                    BIOL 4900.705, Special Problems, Fall 2007 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2007 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2007 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2007 
                    

                    BIOC 6950.705, Doctoral Dissertation, Spring 2007 
                    

                    BIOC 6940.705, Individual Research, Spring 2007 
                    

                    BIOL 4900.705, Special Problems, Spring 2007 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2006 
                    

                    BIOL 6950.705, Doctoral Dissertation, Fall 2006 
                    

                    BIOC 6940.705, Individual Research, Fall 2006 
                    

                    BIOC 5950.705, Master's Thesis, Fall 2006 
                    

                    BIOC 5900.705, Special Problems, Fall 2006 
                    

                    BIOC 5910.705, Special Problems, Fall 2006 
                    

                    BIOC 6910.705, Special Problems, Fall 2006 
                    

                    BIOL 4900.705, Special Problems, Summer 10W 2006 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2006 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2006 
                    

                    BIOC 6940.705, Individual Research, Spring 2006 
                    

                    BIOC 5950.705, Master's Thesis, Spring 2006 
                    

                    BIOC 4900.705, Special Problems, Spring 2006 
                    

                    BIOC 6910.705, Special Problems, Spring 2006 
                    

                    BIOC 6940.705, Individual Research, Fall 2005 
                    

                    BIOC 6630.001, Protein Structure and Function, Fall 2005 
                    

                    BIOC 4900.705, Special Problems, Fall 2005 
                    

                    BIOL 4900.705, Special Problems, Fall 2005 
                    

                    BIOL 6900.705, Special Problems, Fall 2005 
                    

                    BIOL 6910.705, Special Problems, Fall 2005 
                    

                    BIOC 4900.705, Special Problems, Summer 5W1 2005 
                    

                    BIOC 4900.705, Special Problems, Summer 5W2 2005 
                    

                    BIOC 4550.001, Biochemistry II, Spring 2005 
                    

                    BIOC 5550.001, Biochemistry II, Spring 2005 
                    

                    BIOC 6940.705, Individual Research, Spring 2005 
                    

                    BIOC 4900.705, Special Problems, Spring 2005 
                    

                    BIOC 6900.705, Special Problems, Spring 2005 
                    

                    BIOL 6200.001, Bioinstrumentation and Analytical Techniques, Fall 2004 
                    

                    BIOC 6950.705, Doctoral Dissertation, Fall 2004 
                    

                    BIOC 6940.705, Individual Research, Fall 2004 
                    

                    BIOC 6910.705, Special Problems, Fall 2004 
                    

                    BIOL 4910.705, Special Problems, Fall 2004 

          


          
*
  Texas Education Code 51.974 (HB 2504) requires each institution of
  higher education to make available to the public, a syllabus for
  undergraduate lecture courses offered for credit by the institution.
  

        

      

    

  

  
  	

	

	  

		

		   
Published Publications



  

  
Published Intellectual Contributions


  
Abstracts and Proceedings
Quedan, D. D., Root, D. D. (2022). ANTI-S2 PEPTIDES AND ANTIBODIES BIND COOPERATIVELY TO THE MYOSIN DIMER WITH HIGH AFFINITY AND STABILIZE THE UNFOLDED STATE OF S2. Biophysical Journal. 140(3), 22-A-1199-BPS.  Denton:. 
Root, D. D., Quedan, D. D., Qadan, M. D., Levitan, B. M., Thompson, M. S., Campbell, K.  (2022). ANTI-S2 PEPTIDES TARGET CARDIAC MYOSIN FOR IN VIVO RESPONSES. Biophysical Journal. 140, 22-A-1075-BPS.  Denton:. 
Migliore, J. R., Root, D. D. (2022). TRANSMITTED LIGHT IMAGING REVEALS SARCOMERIC ULTRASTRUCTURE IS PRESERVED IN EXPANSION MICROSCOPY. Biophysical Journal. 140(3), #22-A-1430-BPS. Cell. 
Qadan, M. D., Root, D. D. (2021). The Design of a Destabilizer Peptide to Disrupt SARS-CoV-2 Fusion with Its Targeted Cell Membrane. Biophysical Journal. 120(3), 204A. Cell. 
Migliore, J. R., Root, D. D. (2021). Using Enzyme-Linked Markers with Chromogenic Substrates in Expansion Microscopy. Biophysical Journal. Biophysical Journal. 120(3), 360A.  Denton: Cell. 
Root, D. D. (2020). BINDING SITE ANALYSIS OF AN ANTI-TROPOMYOSIN DESTABILIZING PEPTIDE USING FLUORESCENCE MICROSCOPY AND SPECTROSCOPY. Biophysical Journal. 108(3), 276A-277A. 
Aboonsrshiraz, N., Root, D. D. (2020). IMPACT OF ANTI-S2 PEPTIDES ON MYOSIN S2 ISOFORMS AND HCM MUTANTS.. Biophysical Journal. 108(3), 427A. Cell. 
Tanner, B., Campbell, K., Qadan, M., Aboonsrshiraz, N., Quedan, D., Awinda, P., Bernardino-Shafer, A., Guglin, M., Root, D. D. (2019). ANTI-S2 PEPTIDES MODULATE MYOSIN COILED-COIL STRUCTURE AND SHIFT FORCE-pCa CURVES IN HUMAN CARDIAC MUSCLE. Biophysical Journal. Biophysical Journal. 116(3), 263a. Cell. 
Quedan, D., Bernardino-Schaefer, A., Singh, R., Thang, C., Bhaskaruni, M., Srivastava, R., Root, D. D. (2018). Cooperative Activation of Striated Muscle Thick Filaments by S2 Binding. Texas Journal of Microscopy. 49(1), 13.  Texas: Texas Society of Microscopy. www.texasmicroscopy.org
Quedan, D., Bernardino-Schaefer, A., singh, R., Thang, C., Bhaskaruni, M., Srivastava, R., Root, D. D. (2018). Cooperative activation of the striated muscle thick filament via S2 binding. Biophysical Journal. 114(3), 646a.  Cambridge, MA: Cell Press. www.cell.com/biophysj/home
Singh, R., Qadan, M., Aboonsrshiraz, N., Quedan, D., Wang, D., Root, D. D. (2017). Peptide designed to destabilize the myosin coiled coil enhance myofibril shortening while peptides that stabilize the coiled coil inhibit myofibril shortening. Biophysical Journal. 112, 557a. 
Singh, R., Zheng, V., Ma, C., Root, D. D. (2016). Competitive Binding to Myosin S2 by C-Protein, Anti-S2 Peptides, and Antibodies Modulate Myosin Coiled-Coil Stability and Myofibril Contractility.. Biophysical Journal. 110, 292a. 
Aboonsrshiraz, N., Huang, A., Ma, C., Root, D. D. (2016). Development of High Affinity Anti-S2 Peptides for Stabilizing the Myosin Coiled-Coil. Biophysical Journal. 110, 292a. 
Dunn, J., Bih, M., Singh, R., Root, D. D. (2015). Peptide Modulation of Myosin Coiled Coil Stability Monitored with Optical and Force Spectroscopy. Biophysical Journal. 108(2), 446a. 
Root, D. D. (2009). "Photoactivatable Quantum Dots in Super-Resolution 3D Microscopy of Myofibrils .". 
Root, D. D. (2008). "Computational Estimation of the Energy Requirements for Conformational Transitions in Skeletal Muscle Myosin .". 
Root, D. D. (2008). "Troponin/Tropomyosin Determines Myosin Target Zones Along the Thin Filament .". 
Root, D. D. (2007). "Fluorescent labeling of the myosin strut.". 
Root, D. D. (2006). "A Novel Fluorescent Nanocircuit Reports Nanometer Scale Conformational Changes Between the Interacting Molecules of Muscle Contraction". 
Root, D. D. (2006). "A Novel Fluorescent Nanocircuit Reports on the Lever Arm Position of Thin Filament Bound Myosin S1 ". 
Root, D. D. (2006). "LRET-Based 3-D Mapping of Skeletal Troponin T Relative to Myosin S1 Bound to Regulated Actin". 
Root, D. D. (2006). "Measured Variability in the Unwinding of the Myosin Coiled Coil"

Related Links:. 
Root, D. D. (2006). "Nanomanipulations and Molecular Simulations of Single Fibrous Muscle Myosin Proteins". 
Root, D. D. (2005). " The structural relationship of muscle myosin to thin filament regulatory proteins". 
Root, D. D. (2005). "Computational estimation of the consequences of cleft movement in skeletal muscle myosin.". 
Root, D. D. (2005). "Nanomechanics of Coiled-Coil Domains in Myosin". 
Root, D. D. (2005). "The Structure of Troponin T N-terminal Tx Motifs upon Ca2+ Binding". 
Root, D. D. (2004). " Resonance Energy Transfer of Pre- and Post-Powerstroke States of Myosin to Troponin.". 
Root, D. D. (2004). "Does Muscle Crossbridge Flexibility Reside Mostly in the Myosin Head or Subfragment 2?". 
Root, D. D. (2004). "Lanthanide Probes for Detecting Insertion, Deletion, or Alternative Splicing Variants.". 
Root, D. D. (2004). "Structural Prediction and Calcium Binding Analysis of a Novel Troponin T N-terminal Fragment.". 
Root, D. D. (2003). "A Single Molecule Fluorescent Assay Detects Nucleotide-Dependent Effects on Actin and Myosin Crossbridge Flexibility ". 
Root, D. D. (2003). "Binding of Calcium to Avian Pectoral Troponin T". 
Root, D. D. (2002). " Spectroscopic and Computational Analysis of the Actomyosin Interface". 
Root, D. D. (2002). "First Contact of Myosin Binding Actin". 
Root, D. D. (2002). "Myosin Twisting on Actin". 
Root, D. D. (2001). "D ocking Atomic Models of Actin and Myosin". 
Root, D. D. (2001). "D ocking Atomic Models of Weak and Strong Binding States of Actomyosin by Resonance Energy Transfer". 
Root, D. D. (2001). "Spectroscopic Mapping of Troponin T Reveals Site-Specific Conformational Perturbations by Thin Filament Proteins". 
Root, D. D. (2000). "Conformational States of Myosin Subfragment-1 on Actin,". 
Root, D. D. (2000). "N-terminal Variable Region-Based Modulation of Conformation and Flexibility of Troponin T: A Fluorescence Spectral Study,". 
Root, D. D. (2000). "Noncovalent Crosslinking of SH1 and SH2 in Myosin Demonstrates Dynamic Flexibility of the Melted SH1-SH2 -Helix,". 
Root, D. D. (1999). " Structural Changes at the Actomyosin Interface,". 
Root, D. D. (1999). "Determination of Fluorescent Probe Orientations on Macromolecules by Conformational Searching,". 
Root, D. D. (1999). "Hydrophobic Modulation Liquid Chromatography for the Purification of Myosin Subfragments.". 
Root, D. D. (1999). "Structural Transitions at the Actomyosin Interface,". 
Root, D. D. (1998). "Calibrations and Corrections for Probe Size Effects in Resonance Energy Transfer Measurements,". 
Root, D. D. (1998). "Long-Distance Resonance Energy Transfer Between the Regulatory Light Chain and Nucleotide Analogs in Skeletal Muscle Myosin,". 
Root, D. D. (1998). "Sensitized Emission Immuno-Resonance Energy Transfer (SEIRET) Microscopy: Applications to Actin-Associated Proteins,". 
Root, D. D. (1997). "In Situ Molecular Association of Dystrophin with Actin Revealed by Sensitized Emission Immuno-Resonance Energy Transfer,". 
Root, D. D. (1996). "Nebulin Fragment Alters Rigor Binding of Myosin Subfragment-1 to Actin,". 
Root, D. D. (1995). "Nebulin Fragment Binds Both S-1 and Prevents Binding to Actin,". 
Root, D. D. (1995). "Single Nebulin Superrepeat Affects Multiple Actin Protomers in Actomyosin Interaction and Actin Polymerization,". 
Root, D. D. (1994). "Nebulin-Calmodulin As A New Calcium Regulatory System On The Thin Filament Of Skeletal Muscle,". 
Root, D. D. (1993). "Highly Sensitive Silver and Copper-Based Staining Assays for Protein on Blots and Microtiter Plates,". 
Root, D. D. (1993). "Nebulin is a Giant Actin-Binding Protein: High Affinity Binding Sites and Videomicroscopy of Actin-Nebulin,". 
Root, D. D. (1992). "Catalytic Cooperativity of Modified Myosin Filaments,". 
Root, D. D. (1991). "Fluorescence Quenching of Etheno-Nucleotides in G- and F-Actin,". 
Root, D. D. (1990). "Copper Iodide Staining and Determination of Proteins Adsorbed to Microtiter Plates,". 
Root, D. D. (1987). "Disturbance in Colonic Contraction in Colonic Muscle Removed from Patients with Ulcerative-Colitis". 
Book
Berg et al., J. M., Root, D. D. (2015). Clinical Companion to Biochemistry 8th ed.. 2015(8th), 179 out of 637 pp.  New York, NY: W. H. Freeman & Company. https://reg.macmillanhighered.com/Account/Unauthenticated?TargetURL=http%3a%2f%2fwww.macmillanhighered.com%2flaunchpad%2fberg8e%2f1597451
Book Chapter
Root, D. D. (2002). "Copper Iodide Staining of Proteins," In Basic Protein and Peptide Protocols Second Ed. (Ed. John M. Walker). 
Root, D. D. (2002). "Kinetic Silver Staining of Proteins," In Basic Protein and Peptide Protocols Second Ed. (Ed. John M. Walker). 
Root, D. D. (1996). "Copper Iodide Staining of Proteins on Solid Phases," In Basic Protein and Peptide Protocols (Ed. John M. Walker).. 
Root, D. D. (1996). "Kinetic Silver Staining of Proteins Adsorbed to Microtiter Plates," In Basic Protein and Peptide Protocols (Ed. John M. Walker). 
Journal Article
Singh, R. R., Dunn, J. W., Qadan, M. M., Hall, N., Wang, K. K., Root, D. D. (2018). Data on whole length myosin binding protein C stabilizes myosin S2 as measured by gravitational force spectroscopy. 18, 1099-1106.  New York: Data in Brief (Elsevier). https://www.sciencedirect.com/science/article/pii/S2352340918303536
Mondal, H., Louis, J., Archer, L., Patel, M., Nalam, V., Sarowar, S., Sivapalan, V., Root, D. D., Shah, J.  (2018). Arabidopsis thaliana ACTIN DEPOLYMERISING FACTOR 3 is required for controlling aphid feeding from the phloem. Plant Physiology. 176, 879-890. American Society of Plant Biologists. 
Singh, R. R., Dunn, J. W., Qadan, M. M., Hall, N., Wang, K. K., Root, D. D. (2018). Whole length myosin binding protein C stabilizes myosin S2 as measured by gravitational force spectroscopy. Archives of Biochemistry and Biophysics. 638, 41-51.  Amsterdam, The Netherlands: Elsevier. https://www.journals.elsevier.com/archives-of-biochemistry-and-biophysics
Root, D. D. (2013). Asymmetric Myosin Binding to the Thin Filament as Revealed by a Fluorescent Nanocircuit. Archives of Biochemistry and Biophysics. 535(1), 14-21. 
Root, D. D. (2011). Demonstrating the uses of the novel Gravitational Force Spectrometer to stretch and measure fibrous proteins. 
Root, D. D. (2009). " Close Proximity of Myosin Loop 3 to Troponin Determined by Triangulation of Resonance Energy Transfer Distance Measurements,". 
Root, D. D. (2006). " Coiled-coil Nanomechanics and Uncoiling and Unfolding of the Superhelix and Alpha-Helices of Myosin". 
Root, D. D. (2006). " Downscaling Functional Bioassays by Single Molecule Techniques". 
Root, D. D. (2006). " Fluorescence labeling and computational analysis of the strut of myosin's 50 kDa cleft". 
Root, D. D. (2005). "High Flexibility of the Actomyosin Crossbridge Resides in Skeletal Muscle Myosin Subfragment-2 as Demonstrated by a New Single Molecule Assay". 
Root, D. D. (2004). " Binding of Calcium Ions to an Avian flight Muscle Troponin T,". 
Root, D. D. (2004). " Detection of Single Nucleotide Variations by a Hybridization Proximity Assay Based on Molecular Beacons and Luminescence Resonance Energy Transfer.". 
Root, D. D. (2002). " A Computational Comparison of the Atomic Models of the Actomyosin Interface". 
Root, D. D. (2002). " Dynamic Docking of Myosin and Actin Observed with Resonance Energy Transfer.". 
Root, D. D. (2002). " The Dance of Actin and Myosin: A Review of the Mechanism of Actomyosin Motility.". 
Root, D. D. (2001). "High-Affinity Actin-Binding Nebulin Fragments Influence the ActoS1 Complex,". 
Root, D. D. (2000). "Conformational Selection during Weak Binding at the Actin and Myosin Interface.". 
Root, D. D. (2000). "Modulation of Troponin T Molecular Conformation and Flexibility by Metal Ion Binding to the N-Terminal Variable Region.". 
Root, D. D. (2000). "Native Purification of Biomolecules with Temperature Mediated Hydrophobic Modulation Liquid Chromatography,". 
Root, D. D. (1999). " Determination of Fluorescent Probe Orientations on Biomolecules by Conformational Searching: Algorithm Testing and Applications to the Atomic Model of Myosin,". 
Root, D. D. (1998). "Domain Motion between the Regulatory Light Chain and the Nucleotide Site in Skeletal Muscle Myosin,". 
Root, D. D. (1997). "In Situ Molecular Association of Dystrophin with Actin Revealed by Sensitized Emission Immuno-Resonance Energy Transfer,". 
Root, D. D. (1994). "Calmodulin-Sensitive Interaction of Human Nebulin Fragments With Actin And Myosin,". 
Root, D. D. (1993). "Enhanced Stimulation of Myosin Subfragment 1 ATPase Activity by Addition of Negatively Charged Residues to the Yeast Actin N-Terminus.". 
Root, D. D. (1993). "Kinetic Silverstaining and Calibration of Proteins Adsorbed to Microtiter Plates.". 
Root, D. D. (1993). "Silver-Enhanced Copper Staining of Protein Blots.". 
Root, D. D. (1992). "Cooperativity of Thiol-Modified Myosin Filaments: ATPase and Motility Assays of Myosin Function,". 
Root, D. D. (1992). "The Accessibilities of Etheno-Nucleotides to Collisional Quenchers and the Nucleotide Cleft in G- and F-Actin,". 
Root, D. D. (1991). "Catalytic Cooperativity Induced by SH1 Labeling of Myosin Filaments,". 
Root, D. D. (1990). "Copper Iodide Staining and Determination of Proteins Adsorbed to Microtiter Plates,". 
Root, D. D. (1989). "Copper Iodide Staining of Protein Blots on Nitrocellulose Membranes,". 
Root, D. D. (1989). "Response of Smooth Muscle from Proximal and Distal Human Colon,". 
Root, D. D. (1987). "Calcium Dependence of Neurotensin Stimulation of Circular Colonic Muscle of the Rabbit,". 



	
		
		
	  

	

	

  
    
	

	

	  

		

		   
Awarded Grants



  
  
  	  
          
Contracts, Grants and Sponsored Research  

 	 
	 	 
  
Grant - Research   
Root, D. D. (Co-Principal), Campbell, K. (Principal), Tanner, B. (Co-Principal), McDonald, K. (Co-Principal), Kampourakis, T. (Co-Principal), "Length-dependent activation in human myocardium," Sponsored by NIH, University of North Texas, $2981821 Funded. (September 2020 – June 2024).
Root, D. D. (Principal), Verbeck, G. (Co-Principal), "Development of Heart-Targeted Therapeutic Peptides and their Characterization by Mass Spectroscopy," Sponsored by COS, University of North Texas, $9000 Funded. (June 1, 2019 – December 31, 2019).
Root, D. D. (Other), "Faculty Research Grants," University of North Texas, $40100 Funded. (1996 – 2014).
Root, D. D. (Other), "UNT Excellence," Sponsored by UNT, University of North Texas, $438343 Funded. (2005 – 2007).
Neogi, A., Omary, M. A., Root, D. D., Gorman, B., "NSF MRI, Development of Near-field optical microscope," Sponsored by National Science Foundation, Federal, $520000 Funded. (September 9, 2006 – August 8, 2007).
Root, D. D. (Other), "Junior Faculty Summer Research Fellowships," University of North Texas, $10500 Funded. (1996 – 1997).



	
		
		
	  

	

	

	
	

  
  
  

  	

		

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					Overall
Summative Rating		
					Challenge and
Engagement Index		
					Response Rate
					
				

			
			
				

					
					
out of 5		
					
out of 7		
					%
 of 
students responded		
					
					
				

			
		


		
    
			
  • Overall Summative Rating (median):
    
			This rating represents the combined responses of students to the four global summative items and is presented to provide an overall index of the class’s quality. Overall summative statements include the following (response options include a Likert scale ranging from 5 = Excellent, 3 = Good, and 1= Very poor):
				
      
					
    • The course as a whole was
      • 
					
    • The course content was
      • 
					
    • The instructor’s contribution to the course was
      • 
					
    • The instructor’s effectiveness in teaching the subject matter was
      • 
				
    
			
    • 
			
  • Challenge and Engagement Index:
    
			This rating combines student responses to several SPOT items relating to how academically challenging students found the course to be and how engaged they were. Challenge and Engagement Index items include the following (response options include a Likert scale ranging from 7 = Much higher, 4 = Average, and 1 = Much lower):
				
      
					
    • Do you expect your grade in this course to be
      • 
					
    • The intellectual challenge presented was
      • 
					
    • The amount of effort you put into this course was
      • 
					
    • The amount of effort to succeed in this course was
      • 
					
    • Your involvement in course (doing assignments, attending classes, etc.) was
      • 
				
    
			
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