Daniel Afosah

Previous Scheduled Teaching

Published Intellectual Contributions

Abstracts and Proceedings

• Afosah, D. (2023). Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis.. 83 3394.
• Afosah, D. (2022). Non-Saccharide Glycosaminoglycan Mimetics as Inhibitors of Cathepsin G. 32 1016-1017.
• Afosah, D. (2021). Quantitative Analysis of Highly Sulfated, Lipid-conjugated Mimetics of Glycosaminoglycans in Human Plasma. 31 1753.
• Afosah, D. (2020). Cholesterol modification enhances potency and pharmacokinetic properties of a selective cancer stem cell targeting agent. 80 6353.
• Afosah, D. (2019). A small, synthetic glycosaminoglycan mimetic as an inhibitor of human heparinase.. FASEB Journal. 33 (Suppl 1) 675.12-675.12.
• Afosah, D. (2019). Computational modeling of 2-O, 3-O-desulfated heparin interaction with p300 histone acetyl transferase.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 257
• Afosah, D. (2019). Glycosaminoglycans and Glycosaminoglycan Mimetics as Human Neutrophil Elastase Inhibitors for Cystic Fibrosis Management. FASEB Journal. 33 (Suppl 1) 782.2-782.2.
• Afosah, D. (2019). Lipophilic Modification of an Anti‐Cancer Stem Cell Agent Improves Pharmacokinetic and Anti‐Cancer Properties.. FASEB Journal. 33 (Suppl 1) 782.17-782.17.
• Afosah, D. (2019). Many Apparently Non-Selective GAG – Protein Systems May Exhibit Interesting Selectivity Features: The Case of Human Neutrophil Elastase.. 29 953.
• Afosah, D. (2019). Relationship between modified heparin-derived oligosaccharide non-polar surface areas and electrospray ionization response. 29 951.
• Afosah, D. (2019). Selective Inhibition of a Panel of Cancer Stem Cell Lines by Novel Glycosaminoglycan Mimetics. FASEB Journal. 33 (Suppl 1) 675.11-675.11.
• Afosah, D. (2017). Molecular Determinants of Neutrophil Elastase Inhibition By 2-O, 3-O Desulfated Heparin. American Journal of Respiratory and Critical Care Medicine. 195 A1287.
• Afosah, D. (2017). Neutrophil Elastase Inhibition by DNA or Heparin is Polymer Length Dependent.. American Journal of Respiratory and Critical Care Medicine. 195 A1286.
• Afosah, D. (2016). 2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box1 Release from Macrophages by Inhibition of P300 Acetyltransferase Activity. American Journal of Respiratory and Critical Care Medicine. 193 A5566.
• Afosah, D. (2016). Computational modeling of 2-O, 3-O-desulfated heparin interaction with p300 histone acetyl transferase.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 252
• Afosah, D. (2016). Reducing bleeding risks of anticoagulants through a novel partial inhibition approach. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 252

Book Chapter

• Afosah, D., Morla, S., Campbell, C., Desai, U. (2021). Natural products for Cardiovascular Diseases Treatment.. 1 San Diego, Cognella.

Journal Article

• Dumas, A., Goyal, N., Mottamal, M., Afosah, D., Al-Horani, R. (2024). Discovery of a New Lead Molecule to Develop a Novel Class of Human Factor XIIa Inhibitors.. 57 (8) 1308-1314. Springer Nature. https://link.springer.com/article/10.1007/s11239-024-03054-2
• Vu, K., Kar, S., Mottamal, M., Afosah, D., Al-Horani, R. (2024). Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa. ACS Omega. 9 (28) 31105-31119. Washington, DC, American Chemical Society. https://pubs.acs.org/doi/10.1021/acsomega.4c04518
• Woodland, M., , A.T., , A.L., Goyal, N., Schexnaildre , J., Mottamal , M., Afosah, D., Al-Horani, R. (2024). New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants.. ACS Omega. 9 (9) 10694-10708. Washington, DC, American Chemical Society.
• Pradhan, A., Modi, J., Maji, S., Kumar, A., Bhoopathi, P., Mannangatti, P., Gu, C., Afosah, D., Mochel, M., Mukhopadhya, N., Kirkwood, J., Wang, X., Desai, U., Sarkar, D., Emdad, L., Das, S., Fisher, P. (2023). Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis. 22 (10) 1115-1127. Philadelphia, PA, American Association for Cancer Research. https://aacrjournals.org/mct/article/22/10/1115/729311/Dual-Targeting-of-the-PDZ1-and-PDZ2-Domains-of-MDA
• Chiles, R., Afosah, D., Al-Horani, R. (2023). Investigation of the Anticoagulant Activity of Cyclic Sulfated Glycosaminoglycan Mimetics.. 529 108831. Amsterdam, Elsevier. https://linkinghub.elsevier.com/retrieve/pii/S0008621523000939
• Afosah, D.K., Fayyadd, R., Puliafico, V., Merrell, S., Langmia, E., Diagne, S., Al-h, R., Umesh, D. (2023). Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G. 13 (5) 760. Basel, MDPI. https://www.mdpi.com/2218-273X/13/5/760
• Afosah, D., Abdelfadiel, E., Gunta, R., villuri, B., Sanakaranarayanan, N., Desai, U. (2023). Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors. 66 (7) 4503–4531. Washington, DC, American Chemical Society. https://doi.org/10.1021/acs.jmedchem.3c00132
• Morla, S., Ongolu, R., O'Hara, C., Vera, A., Abdelfadiel, E., Fayadd, R., Afosah, D., Sharon, C., Fernandez, L., Shah, S., Patel, B., Desai, U. (2023). Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. 66 (2) 1321-1338. Washington, DC, American Chemical Society. https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01511
• Al-Horani, R., Afosah, D., Kar, S., Aliter, K., Mottamal, M. (2023). Sulphated Penta-Galloyl Glucopyranoside (SPGG) Is Glycosaminoglycan Mimetic Allosteric Inhibitor of Cathepsin G. 2 (1) 1–9. Oxford, Oxford Press. https://academic.oup.com/rpsppr/article/2/1/rqad001/6972762
• Al-Horani, R., Afosah, D., Mottamal, M. (2022). Triazol-1-Yl Benzamides Promote Anticoagulant Activity via Inhibition of Factor XIIa.. 21 (2) 108-119. Sharjah, Bentham Science Publishers. https://www.eurekaselect.com/article/127299
• Boothello, R., Sankaranarayanan, N., Sisthla, J., Nagarajan, B., Sharon, C., Chittum, J., Niyaz, R., Roy, S., Nandi, A., O'Harra, C., Gangji, R., Afosah, D., Ongolu, R., Patel, B., Desai, U. (2022). Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor. Angewandte Chemie International Edition. 134 (49) e202211320. Weinheim, Wiley-VCH GmbH. https://onlinelibrary.wiley.com/doi/10.1002/anie.202211320
• Afosah, D., Ofori, E., Mottamal, M., Al-Horani, R. (2022). Factor IX(a) Inhibitors: An Updated Patent Review (2003-Present). 32 (4) 381-400. Oxford, Taylor & Francis. https://www.tandfonline.com/doi/full/10.1080/13543776.2022.2026926
• Afosah, D., Kar, S., , R., Bankston, P. (2021). Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa. 14 (9) 886. Basel, MDPI. https://www.mdpi.com/1424-8247/14/9/886
• Boothello, R., Sankaranarayanan, N., Afosah, D., Al-Horani, R., Karuturi, R., Desai, U. (2020). Studies on Fragment-Based Design of Allosteric Inhibitors of Human Factor XIa. Bioorganic & Medicinal Chemistry. 28 (23) 1101-1105. Oxford, Elsevier.
• Afosah, D., , R. (2020). Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies. 27 (21) 3412-3447. Sharjah, Bentham Science Publishers.
• Al-Horani, R., Abdelfadiel, E., Afosah, D., Morla, S., Sisthla, J., Mohammed, B., Martin, E., Brophy, D., Sakagami, M. (2019). A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. Journal of Thrombosis and Haemostasis. 17 (12) 2110-2122. Philadelphia, PA, Elsevier.
• Afosah, D., Morla, S., Sankaranarayanan, N., Kumar, M., Kummarapurugu, A., Voynow, J., Desai, U. (2019). On the Process of Discovering Leads that Target the Heparin‐Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients. 62 (11) 5501 – 5511. Washington, DC, American Chemical Society.
• Patel, N., Patel, D., Kanhed, A., Patel, S., Patel, K., Afosah, D., Desai, U., Karpoormath, R., Yadav, M. (2019). 2‐Aminobenzamide‐Based Factor Xa Inhibitors with Novel Mono‐ and Bi‐Aryls as S4 Binding Elements.. 4 (3) 802-809. Weinheim, Wiley-VCH.
• Gangji, R., Sankaranarayanan, N., Elste, J., Al-Horani, R., Afosah, D., Joshi, R., Tiwari, V., Desai, U. (2018). Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Non-Saccharide Glycosaminoglycan Mimetics.. 9 (8) 797-802. Washington, DC, American Chemical Society.
• Kumarapurugu, A., Afosah, D., Sankaranarayanan, N., Gangji, R., Zheng, S., Kennedy, T., Rubin, B., Desai, U., Voynow, J. (2018). Molecular Principles for Heparin Oligosaccharide-Based Inhibition of Neutrophil Elastase in Cystic Fibrosis. Journal of Biological Chemistry. 293 (32) 12480 – 12490. Rockville, MD, American Society for Biochemistry and Molecular Biology.
• Al-Horani, R., Afosah, D. (2018). Recent Advances in the Discovery and Development of Factor XI/XIa Inhibitors.. 38 (6) 1974-2023. Hoboken, NJ, John Wiley & Sons, Inc..
• Afosah, D., Verespy, S., Al-Horani, R., Boothello, R., Karuturi, R., Desai, U. (2018). A Small Group of Sulfated Benzofurans Induce Steady-State Submaximal Inhibition of Thrombin.. 28 (6) 1101-1105. Oxford, Elsevier Ltd.
• Afosah, D., Al-Horani, R., Sankaranarayanan, N., Desai, U. (2016). Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. 60 641-657. Washington, DC, American Chemical Society.
• Zheng, S., Kumarapurugu, A., Afosah, D., Sankaranarayanan, N., Boothello, R., Desai, U., Kennedy, T., Voynow, J. (2016). 2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity. 56 (1) 90-98. New York, NY, American Thoracic Society.
• Karuturi, R., Al-Horani, R., Lee, M., Afosah, D., Desai, U. (2016). Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.. PLOS One. 11 (7) e0160189. San Francisco, CA, Public Library of Science.
• Verespy, S., Mehta, A., Afosah, D., Al-Horani, R., Desai, U. (2016). Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, Not Just Inhibition, of Thrombin. Scientific Reports. 6 24043. London, Nature Publishing Group.

Manuscript

• Afosah, D., Ongolu, R., Fayyadd, R., Hawkridge, A., Desai, U. (2025). A Robust Proteomics-Based Method for Identifying Preferred Protein Targets of Synthetic Glycosaminoglycan Mimetics. Cold Spring Harbor Laboratory. https://www.biorxiv.org/content/10.1101/2025.01.23.634492v1

Contracts, Grants and Sponsored Research

Grant - Research

• Afosah, D. (Principal), Jagadeeswaran, P. (Supporting), "Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis," sponsored by NIH-NHLBI, Federal, $682552 Funded. (2024 - 2027).
• Afosah, D. (Principal), "Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis," sponsored by NIH-NHLBI, Federal, $358776 Funded. (2022 - 2024).