Elizabeth J. Skellam

Previous Scheduled Teaching

Published Intellectual Contributions

Book

• Skellam, E. (2022). Methods in Molecular Biology: Engineering Natural Products Biosynthesis. 2489 Springer Nature. https://link.springer.com/book/9781071622728

Book Chapter

• Skellam, E. (2021). Analysis of the secondary metabolism in Magnaporthe oryzae. Methods in Molecular Biology: Magnaporthe.
• Cox, R., Skellam, E. (2020). 1.09 Fungal Non-Reducing Polyketide Synthases. Comprehensive Natural Products III. https://books.google.com/books?hl=en&lr=&id=xXHhDwAAQBAJ&oi=fnd&pg=PA266&ots=Egc1U2N61r&sig=bO7YvGQG9pBfa-dhK1EL57D7Bao#v=onepage&q&f=false
• Cox, R., Skellam, E., Williams, K. (2018). Biosynthesis of fungal polyketides. The Mycota -,Physiology and,Genetics XV.

Journal Article

• Skellam, E. (2022). Subcellular compartmentalization of fungal biosynthetic enzymes. 9 Springer Link. https://link.springer.com/article/10.1186/s40694-022-00140-z
• Shenouda, M., Ambilika, M., Skellam, E.J., Cox, R.J. (2022). Heterologous Expression of Secondary Metabolite Genes in Trichoderma reesei for Waste Valorization.
• Kahlert, L., Villanueva, M., Cox, R., Skellam, E. Biosynthesis of 6-Hydroxymellein Requires a Collaborating Polyketide Synthase-like Enzyme. Angewandte Chemie International Edition. 60 (20) 11423-11429. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202100969
• Feng, J., hauser, m., Cox, R., Skellam, E. (2021). Engineering Aspergillus oryzae for the Heterologous Expression of a Bacterial Modular Polyketide Synthase. 7 (12) MPDI. https://www.mdpi.com/2309-608X/7/12/1085
• Skellam, E.J. (2021). Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes. 39 RSC. https://pubs.rsc.org/en/content/articlelanding/2022/np/d1np00056j/unauth
• Kahlert, L., Bernardi, D., Hauser, M., Ioca, L., Berlinck, R., Skellam, E., Cox, R. (2021). Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. 27 (46) 11895-11903. Wiley. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101447
• Zhang, H., Hantke, V., Brunhke, P., Skellam, E., Cox, R. (2020). Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans. Chemistry: A European Journal.
• Kahlert, L., Cox, R., Skellam, E. (2020). The Same but Different: Multiple Functions of the Fungal Flavin Dependent Monooxygenase SorD from Penicillium chrysogenum. Chemical Communications. 56 10934-10937.
• Wang, C., Lambert, C., Hauser, M., Deuschmann, A., Zeilinger, C., Stradal, T., Rottner, K., Stadler, M., Skellam, E., Cox, R. (2020). Diversely functionalised cytochalasins via mutasynthesis and semi-synthesis. Chemistry: A European Journal. 26 (60) 13578-13583.
• Kahlert, L., Bassiony, E., Cox, R., Skellam, E. (2020). Diels-Alder reactions during the biosynthesis of sorbicillinoids. Angewandte Chemie International Edition. 59 (14) 5816-5822.
• Hantke, V., Skellam, E., Cox, R. (2020). Evidence for Enzyme Catalysed Intramolecular [4+2] Diels-Alder Cyclization During the Biosynthesis of Pyrichalasin H. Chemical Communications. 56 2925-2928.
• Hantke, V., Wang, C., Skellam, E., Cox, R. (2019). Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters. RSC Advances. 9 35797-35802.
• Wang, C., Becker, K., Pfuetze, S., Kuhnert, E., Stadler, M., Cox, R., Skellam, E. (2019). Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis. Organic Letters. 21 (21) 8756–8760.
• Wang, C., Hantke, V., Cox, R., Skellam, E. (2019). Targeted gene inactivations expose silent cytochalasans in Magnaporthe grisea NI980. Organic Letters. 21 (11) 4163–4167. ACS.
• Skellam, E. (2019). Strategies for engineering natural product biosynthesis in fungi. Trends in Biotechnology. 37 (4) 416-427.
• Skellam, E. (2017). The biosynthesis of cytochalasans. 343 1252-1263. RSC.
• Song, Z., Bakeer, W., Marshall, J., Yakasai, A., Khalid, R., Collemare, J., Skellam, E., Therreau, D., Lebrun, M., Lazarus, C., Bailey, A., Simpson, T., Cox, R. (2015). Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae. Chemical Science. 6 4837-4845.
• Skellam, E., Stewart, A., Strangman, W., Wright, J. (2013). Identification of micromonolactam, a new polyene lactam from two marine Micromonospora strains using chemical and molecular methods: Clarification of the biosynthetic pathway from a glutamate starter unit.
• Fisch, K., Skellam, E., Ivson, D., Cox, R., Bailey, A., Lazarus, C., Simpson, T. (2010). Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase.
• Skellam, E., Hurley, D., Davison, J., Lazarus, C., Simpson, T., Cox, R. (2010). Mutation of key residues in the C-methytransferase domain of a fungal highly reducing polyketide synthase.
• Bailey, A., Cox, R., Harley, K., Lazarus, C., Simpson, T., Skellam, E. (2007). Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.
• Smith, B., Skellam, E., Oxley, S., Graham, A. (2007). Highly selective synthesis of oxabicycloalkanes by indium tribromide mediated cyclization reactions of epoxyalkanes.

Contracts, Grants and Sponsored Research

Grant - Research

• Skellam, E.J., Wang, X., "Molecular and structural studies of the first fungal polyketide synthase / non-ribosomal peptide synthetase adenylation domain toward biomolecular probes design," sponsored by UNT BDI, University of North Texas, $10000 Funded. (2022).
• Skellam, E.J. (Principal), "Investigating the Scope and Mode of Dimerization Reactions Catalyzed by Fungal Flavin-dependent Monooxygenases," sponsored by Welch Foundation, Private, $300000 Funded. (2023 - 2026).
• Skellam, E., "Greenhouse-based Production of Fungal-Derived Medicines," sponsored by Keck Foundation, Private, $1400000 Funded. (2022 - 2025).
• Skellam, E.J. (Principal), longo, a. (Co-Principal), "Exploring drug-resistant transporters as a mechanism to identify potent bioactive molecules in potential biocontrol agents," sponsored by BDI, University of North Texas, $30000 Funded. (2023 - 2024).
• Skellam, E., "Developing a Biomanufacturing Platform for the Site-Selective Functionalization and Structural Diversification of Cytochalasan-Based Carbon Skeletons," sponsored by NSF, Federal, $309778 Funded. (2021 - 2024).
• Skellam, E.J., "The chemistry and biology of specialized metabolites produced by the endophytic fungi Acremonium zeae (Sarocladium zeae)," sponsored by Bayer AG / Grants4Ag Initiative, Private, $10000 Funded. (2020 - 2021).
• Cox, R.J., "Understanding and Exploiting Fungal Bisorbicillinoid Biosynthesis," sponsored by German Research Foundation, Federal, $275000 Funded. (2018 - 2021).
• Skellam, E.J. (Principal), "Developing a Biomanufacturing Platform for the Site-Selective Functionalization and Structural Diversification of Cytochalasan-Based Carbon Skeletons," sponsored by National Science Foundation, FED, Funded. (2021 - 2024).
• Skellam, E.J. (Principal), "Grants4Ag," sponsored by Bayer AG, IND, Funded. (2021 - 2023).
• Skellam, E., "The chemistry and biology of specialized metabolites produced by the endophytic fungi Acremonium zeae (Sarocladium zeae)," sponsored by Bayer AG / Grants4Ag Initiative, Private, Funded. (2020 - 2021).
• Cox, R.J., "Understanding and Exploiting Fungal Bisorbicillinoid Biosynthesis," sponsored by German Research Foundation, Federal, Funded. (2018).