PhD, Ohio State University, 2015 Major: Biochemistry Dissertation: Role of the Conserved GT Pase LepA in Escherichia Coli
Current Scheduled Teaching
BIOL 4801.001
Microbial Genetics
Spring 2025
Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.
Previous Scheduled Teaching
No previous courses scheduled.
Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.
Published Intellectual Contributions
Journal Article
Fleming, I.M., Paris, Z., Gaston, K.W., Balakrishnan, R., Fredrick, K., Rubio, M.A., Alfonzo, J.D. A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. Scientific Reports. 6 (1) Springer Science and Business Media LLC. http://dx.doi.org/10.1038/srep21438
Guessous, G., Patsalo, V., Balakrishnan, R., Çağlar, T., Williamson, J.R., Hwa, T. Inherited chitinases enable sustained growth and rapid dispersal of bacteria from chitin particles. Nature Microbiology. 8 (9) 1695-1705. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/s41564-023-01444-5
Dai, X., Zhu, M., Warren, M., Balakrishnan, R., Patsalo, V., Okano, H., Williamson, J.R., Fredrick, K., Wang, Y., Hwa, T. Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nature Microbiology. 2 (2) Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nmicrobiol.2016.231
Balakrishnan, R., Mori, M., Segota, I., Zhang, Z., Aebersold, R., Ludwig, C., Hwa, T. (2022). Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria. Science. 378 (6624) American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/science.abk2066
Balakrishnan, R., de Silva, R.T., Hwa, T., Cremer, J. (2021). Suboptimal resource allocation in changing environments constrains response and growth in bacteria. Other. 17 (12) Springer Science and Business Media LLC. http://dx.doi.org/10.15252/msb.202110597
Dai, X., Zhu, M., Warren, M., Balakrishnan, R., Okano, H., Williamson, J.R., Fredrick, K., Hwa, T., Lee, S.Y. (2018). Slowdown of Translational Elongation in
Escherichia coli
under Hyperosmotic Stress. mBio. 9 (1) American Society for Microbiology. http://dx.doi.org/10.1128/mbio.02375-17
Gibbs, M.R., Moon, K., Chen, M., Balakrishnan, R., Foster, L.J., Fredrick, K. (2017). Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome. Proceedings of the National Academy of Sciences. 114 (5) 980-985. Proceedings of the National Academy of Sciences. http://dx.doi.org/10.1073/pnas.1613665114
Balakrishnan, R., Oman, K., Shoji, S., Bundschuh, R., Fredrick, K. (2014). The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli. Other. 42 (21) 13370-13383. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gku1098
posted-content
Wu, C., Balakrishnan, R., Braniff, N., Mori, M., Manzanarez, G., Zhang, Z., Hwa, T. Cellular perception of growth rate and the mechanistic origin of bacterial growth law. Cold Spring Harbor Laboratory. http://dx.doi.org/10.1101/2021.10.16.464649
Overall Summative Rating (median):
This rating represents the combined responses of students to the four global summative items and is presented to provide an overall index of the class’s quality. Overall summative statements include the following (response options include a Likert scale ranging from 5 = Excellent, 3 = Good, and 1= Very poor):
The course as a whole was
The course content was
The instructor’s contribution to the course was
The instructor’s effectiveness in teaching the subject matter was
Challenge and Engagement Index:
This rating combines student responses to several SPOT items relating to how academically challenging students found the course to be and how engaged they were. Challenge and Engagement Index items include the following (response options include a Likert scale ranging from 7 = Much higher, 4 = Average, and 1 = Much lower):
Do you expect your grade in this course to be
The intellectual challenge presented was
The amount of effort you put into this course was
The amount of effort to succeed in this course was
Your involvement in course (doing assignments, attending classes, etc.) was