Faculty Profile

Tsz Yan Clement Chan

Title
Assistant Professor
Department
Biomedical Engineering
College
College of Engineering

    

Education

PhD, Massachusetts Institute of Technology, 2011.
Major: Biological Chemistry
Dissertation Title: A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
BS, University of Wisconsin-Madison, 2005.
Major: Biochemistry

Current Scheduled Teaching*

No current or future courses scheduled.

* Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.

Previous Scheduled Teaching*

BMEN 5326.001, Biomolecular Engineering, Spring 2022 Syllabus
BMEN 5950.001, Master's Thesis, Spring 2022
BMEN 4326.001, Principles of Biomolecular Engineering, Spring 2022 Syllabus
BMEN 2900.001, Special Problems in Biomedical Engineering, Spring 2022
BMEN 5900.001, Special Problems in Biomedical Engineering, Spring 2022
BMEN 5313.001, Bioengineering of Cellular Systems, Fall 2021 Syllabus SPOT
BMEN 5313.601, Bioengineering of Cellular Systems, Fall 2021 Syllabus SPOT
BMEN 4313.001, Cellular Engineering, Fall 2021 Syllabus SPOT
BMEN 5950.006, Master's Thesis, Fall 2021
BMEN 4980.001, Experimental Course, Spring 2021 Syllabus SPOT
BMEN 5800.001, Topics in Biomedical Engineering, Spring 2021 Syllabus SPOT
BMEN 4980.003, Experimental Course, Fall 2020 Syllabus SPOT
BMEN 5800.003, Topics in Biomedical Engineering, Fall 2020 Syllabus SPOT
BMEN 5800.603, Topics in Biomedical Engineering, Fall 2020 Syllabus SPOT

* Texas Education Code 51.974 (HB 2504) requires each institution of higher education to make available to the public, a syllabus for undergraduate lecture courses offered for credit by the institution.

Published Publications

Published Intellectual Contributions

Journal Article
You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12, . Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
Jiang, X., Dimas, R. P., Chan, C. T., Morcos, F. (2021). Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions. Nature Communications. 12, 5592. https://doi.org/10.1038/s41467-021-25851-6
Dimas, R. P., Jordan, B. R., Jiang, X., Martini, C., Glavy, J. S., Patterson, D. P., Morcos, F., Chan, T. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Other. 47(16), 8913-8925. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz666
Dimas, R. P., Jiang, X., Alberto de la Paz, J., Morcos, F., Chan, T. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Other. 47(10), 5449-5463. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz280
Lee, J. W., Chan, T., Slomovic, S., Collins, J. J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14(6), 530-537. https://api.elsevier.com/content/abstract/scopus_id/85047020981
Chan, T., Lee, J. W., Cameron, D. E., Bashor, C. J., Collins, J. J. (2016). 'Deadman' and 'Passcode' microbial kill switches for bacterial containment. Nature Chemical Biology. 12(2), 82-86. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nchembio.1979
Chan, T., Deng, W., Li, F., Demott, M. S., Babu, I. R., Begley, T. J., Dedon, P. C. (2015). Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28(5), 978-988. https://api.elsevier.com/content/abstract/scopus_id/84929408617
Dwyer, D. J., Belenky, P. A., Yang, J. H., Cody MacDonald,, Martell, J. D., Takahashi, N., Chan, T., Lobritz, M. A., Braff, D., Schwarz, E. G., Ye, J. D., Pati, M., Vercruysse, M., Ralifo, P. S., Allison, K. R., Khalil, A. S., Ting, A. Y., Walker, G. C., Collins, J. J. (2014). Antibiotics induce redox-related physi. Proceedings of the National Academy of Sciences of the United States of America. 111(20), . https://api.elsevier.com/content/abstract/scopus_id/84901059678
Mandal, D., Köhrer, C., Su, D., Babu, I. R., Chan, T., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P. C., Rajbhandary, U. L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Other. 20(2), 177-188. https://api.elsevier.com/content/abstract/scopus_id/84892739139
Su, D., Chan, T., Gu, C., Lim, K. S., Chionh, Y. H., McBee, M. E., Russell, B. S., Babu, I. R., Begley, T. J., Dedon, P. C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Other. 9(4), 828-841. https://api.elsevier.com/content/abstract/scopus_id/84897129376
Begley, U., Sosa, M. S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, T., Su, D., Dedon, P. C., Aguirre-Ghiso, J. A., Begley, T. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Other. 5(3), 366-383. https://api.elsevier.com/content/abstract/scopus_id/84874750617
Patil, A., Dyavaiah, M., Joseph, F., Rooney, J. P., Chan, T., Dedon, P. C., Begley, T. J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Other. 11(19), 3656-3665. https://api.elsevier.com/content/abstract/scopus_id/84867259656
Chan, T., Pang, Y. L., Deng, W., Babu, I. R., Dyavaiah, M., Begley, T. J., Dedon, P. C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3, . https://api.elsevier.com/content/abstract/scopus_id/84864828979
Patil, A., Chan, T., Dyavaiah, M., Rooney, J. P., Dedon, P. C., Begley, T. J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Other. 9(7), 990-1001. https://api.elsevier.com/content/abstract/scopus_id/84865298780
Chan, T., Chionh, Y. H., Ho, C., Lim, K. S., Babu, I. R., Ang, E., Wenwei, L., Alonso, S., Dedon, P. C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis bacille calmette-guérin. Molecules. 16(6), 5168-5181. https://api.elsevier.com/content/abstract/scopus_id/79959627017
Chan, T., Dyavaiah, M., DeMott, M. S., Taghizadeh, K., Dedon, P. C., Begley, T. J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Other. 6(12), 1-9. https://api.elsevier.com/content/abstract/scopus_id/78650683942
Fu, D., Brophy, J. A., Chan, T., Atmore, K. A., Begley, U., Paules, R. S., Dedon, P. C., Begley, T. J., Samson, L. D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30(10), 2449-2459. https://api.elsevier.com/content/abstract/scopus_id/77951981033
Seyedsayamdost, M. R., Chan, T., Mugnaini, V., Stubbe, J., Bennati, M. (2007). PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129(51), 15748-15749. https://api.elsevier.com/content/abstract/scopus_id/37549042071
Seyedsayamdost, M. R., Xie, J., Chan, T., Schultz, P. G., Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129(48), 15060-15071. https://api.elsevier.com/content/abstract/scopus_id/36849004028

Awarded Grants

Contracts, Grants and Sponsored Research

Grant - Research
Chan, C. (Principal), "DESIGN AND CONSTRUCT MODULAR TRANSCRIPTIONAL REPRESSORS TO FACILITATE THE DEVELOPMENT OF LIVING DIAGNOSTICS," Sponsored by National Institutes of Health (Award # 1R15GM135813-01), Federal, $391722 Funded. (December 1, 2020November 30, 2023).
Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," Sponsored by National Science Foundation (Award # 1914538), Federal, $441684 Funded. (July 1, 2019August 30, 2020).
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Overall
Summative Rating
Challenge and
Engagement Index
Response Rate

out of 5

out of 7
%
of
students responded
  • Overall Summative Rating (median):
    This rating represents the combined responses of students to the four global summative items and is presented to provide an overall index of the class’s quality. Overall summative statements include the following (response options include a Likert scale ranging from 5 = Excellent, 3 = Good, and 1= Very poor):
    • The course as a whole was
    • The course content was
    • The instructor’s contribution to the course was
    • The instructor’s effectiveness in teaching the subject matter was
  • Challenge and Engagement Index:
    This rating combines student responses to several SPOT items relating to how academically challenging students found the course to be and how engaged they were. Challenge and Engagement Index items include the following (response options include a Likert scale ranging from 7 = Much higher, 4 = Average, and 1 = Much lower):
    • Do you expect your grade in this course to be
    • The intellectual challenge presented was
    • The amount of effort you put into this course was
    • The amount of effort to succeed in this course was
    • Your involvement in course (doing assignments, attending classes, etc.) was
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