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Tsz Yan Clement Chan

Title: Assistant Professor

Department: Biomedical Engineering

College: College of Engineering

Curriculum Vitae

Curriculum Vitae Link

Education

  • PhD, Massachusetts Institute of Technology, 2011
    Major: Biological Chemistry
    Dissertation: A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
  • BS, University of Wisconsin-Madison, 2005
    Major: Biochemistry

Current Scheduled Teaching

BMEN 5313.001Bioengineering of Cellular SystemsFall 2024
BMEN 6950.017Biomedical Engineering Doctoral DissertationFall 2024
BMEN 4313.001Cellular EngineeringFall 2024
BMEN 6910.018Individual ResearchFall 8W2 2024
BMEN 5950.006Master's ThesisFall 2024

Previous Scheduled Teaching

BMEN 6910.015Individual ResearchSpring 2024
BMEN 5950.001Master's ThesisSpring 2024
BMEN 5800.003Topics in Biomedical EngineeringSpring 2024 SPOT
BMEN 6930.001Translational Biomedical EngineeringSpring 2024 SPOT
BMEN 5313.001Bioengineering of Cellular SystemsFall 2023 SPOT
BMEN 5313.601Bioengineering of Cellular SystemsFall 2023 SPOT
BMEN 4313.001Cellular EngineeringFall 2023 Syllabus SPOT
BMEN 6910.011Individual ResearchFall 2023
BMEN 6910.018Individual ResearchFall 8W2 2023
BMEN 5950.006Master's ThesisFall 2023
BMEN 2900.014Special Problems in Biomedical EngineeringFall 2023
BMEN 5950.006Master's ThesisSummer 10W 2023
BMEN 5800.003Topics in Biomedical EngineeringSpring 2023 SPOT
BMEN 6930.001Translational Biomedical EngineeringSpring 2023 SPOT
BMEN 5313.001Bioengineering of Cellular SystemsFall 2022 SPOT
BMEN 5313.601Bioengineering of Cellular SystemsFall 2022 SPOT
BMEN 4313.001Cellular EngineeringFall 2022 Syllabus SPOT
BMEN 6910.011Individual ResearchFall 2022
BMEN 5326.001Biomolecular EngineeringSpring 2022 SPOT
BMEN 5950.001Master's ThesisSpring 2022
BMEN 4326.001Principles of Biomolecular EngineeringSpring 2022 Syllabus SPOT
BMEN 2900.001Special Problems in Biomedical EngineeringSpring 2022
BMEN 5900.001Special Problems in Biomedical EngineeringSpring 2022
BMEN 5313.001Bioengineering of Cellular SystemsFall 2021 SPOT
BMEN 5313.601Bioengineering of Cellular SystemsFall 2021 SPOT
BMEN 4313.001Cellular EngineeringFall 2021 Syllabus SPOT
BMEN 5950.006Master's ThesisFall 2021
BMEN 4980.001Experimental CourseSpring 2021 Syllabus SPOT
BMEN 5800.001Topics in Biomedical EngineeringSpring 2021 SPOT
BMEN 4980.003Experimental CourseFall 2020 Syllabus SPOT
BMEN 5800.003Topics in Biomedical EngineeringFall 2020 SPOT
BMEN 5800.603Topics in Biomedical EngineeringFall 2020 SPOT

Published Intellectual Contributions

    Journal Article

  • You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12 Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
  • Jiang, X., Dimas, R.P., Chan, C.T., Morcos, F. (2021). Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions. Nature Communications. 12 5592. https://doi.org/10.1038/s41467-021-25851-6
  • Dimas, R.P., Jordan, B.R., Jiang, X., Martini, C., Glavy, J.S., Patterson, D.P., Morcos, F., Chan, T. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Other. 47 (16) 8913-8925. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz666
  • Dimas, R.P., Jiang, X., Alberto de la Paz, J., Morcos, F., Chan, T. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Other. 47 (10) 5449-5463. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz280
  • Lee, J.W., Chan, T., Slomovic, S., Collins, J.J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14 (6) 530-537. https://api.elsevier.com/content/abstract/scopus_id/85047020981
  • Chan, T., Lee, J.W., Cameron, D.E., Bashor, C.J., Collins, J.J. (2016). 'Deadman' and 'Passcode' microbial kill switches for bacterial containment. Nature Chemical Biology. 12 (2) 82-86. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nchembio.1979
  • Chan, T., Deng, W., Li, F., Demott, M.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2015). Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28 (5) 978-988. https://api.elsevier.com/content/abstract/scopus_id/84929408617
  • Dwyer, D.J., Belenky, P.A., Yang, J.H., Cody MacDonald, Martell, J.D., Takahashi, N., Chan, T., Lobritz, M.A., Braff, D., Schwarz, E.G., Ye, J.D., Pati, M., Vercruysse, M., Ralifo, P.S., Allison, K.R., Khalil, A.S., Ting, A.Y., Walker, G.C., Collins, J.J. (2014). Antibiotics induce redox-related physi. Proceedings of the National Academy of Sciences of the United States of America. 111 (20) https://api.elsevier.com/content/abstract/scopus_id/84901059678
  • Mandal, D., Köhrer, C., Su, D., Babu, I.R., Chan, T., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P.C., Rajbhandary, U.L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Other. 20 (2) 177-188. https://api.elsevier.com/content/abstract/scopus_id/84892739139
  • Su, D., Chan, T., Gu, C., Lim, K.S., Chionh, Y.H., McBee, M.E., Russell, B.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Other. 9 (4) 828-841. https://api.elsevier.com/content/abstract/scopus_id/84897129376
  • Begley, U., Sosa, M.S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, T., Su, D., Dedon, P.C., Aguirre-Ghiso, J.A., Begley, T. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Other. 5 (3) 366-383. https://api.elsevier.com/content/abstract/scopus_id/84874750617
  • Patil, A., Dyavaiah, M., Joseph, F., Rooney, J.P., Chan, T., Dedon, P.C., Begley, T.J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Other. 11 (19) 3656-3665. https://api.elsevier.com/content/abstract/scopus_id/84867259656
  • Chan, T., Pang, Y.L., Deng, W., Babu, I.R., Dyavaiah, M., Begley, T.J., Dedon, P.C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3 https://api.elsevier.com/content/abstract/scopus_id/84864828979
  • Patil, A., Chan, T., Dyavaiah, M., Rooney, J.P., Dedon, P.C., Begley, T.J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Other. 9 (7) 990-1001. https://api.elsevier.com/content/abstract/scopus_id/84865298780
  • Chan, T., Chionh, Y.H., Ho, C., Lim, K.S., Babu, I.R., Ang, E., Wenwei, L., Alonso, S., Dedon, P.C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis bacille calmette-guérin. Molecules. 16 (6) 5168-5181. https://api.elsevier.com/content/abstract/scopus_id/79959627017
  • Chan, T., Dyavaiah, M., DeMott, M.S., Taghizadeh, K., Dedon, P.C., Begley, T.J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Other. 6 (12) 1-9. https://api.elsevier.com/content/abstract/scopus_id/78650683942
  • Fu, D., Brophy, J.A., Chan, T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J., Samson, L.D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30 (10) 2449-2459. https://api.elsevier.com/content/abstract/scopus_id/77951981033
  • Seyedsayamdost, M.R., Chan, T., Mugnaini, V., Stubbe, J., Bennati, M. (2007). PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129 (51) 15748-15749. https://api.elsevier.com/content/abstract/scopus_id/37549042071
  • Seyedsayamdost, M.R., Xie, J., Chan, T., Schultz, P.G., Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129 (48) 15060-15071. https://api.elsevier.com/content/abstract/scopus_id/36849004028

Contracts, Grants and Sponsored Research

    Grant - Research

  • Chan, T., "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institute of Health (Award # R35GM142421), Federal, $1525588 Funded. (2021 - 2026).
  • Chan, T., "NIH Instrument Supplement R35GM142421-03S1," sponsored by NIH National Institute of General Medical Sciences, Federal, $247975 Funded. (2023 - 2024).
  • Singh, R. (Principal), Chan, T. (Principal), Hu, M. (Principal), "Genetic Biocontainment Switch to Improve the Safety of Drug Detoxifying Bacteria in Preventing Chemotherapy-induced Diarrhea," sponsored by National Institutes of Health/National Cancer Institute (R41CA275454), Federal, $399999 Funded. (2023 - 2024).
  • Chan, C. (Principal), "DESIGN AND CONSTRUCT MODULAR TRANSCRIPTIONAL REPRESSORS TO FACILITATE THE DEVELOPMENT OF LIVING DIAGNOSTICS," sponsored by National Institutes of Health (Award # 1R15GM135813-01), Federal, $391722 Funded. (2020 - 2023).
  • Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, $441684 Funded. (2019 - 2020).
  • Chan, T. (Principal), "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institutes of Health, FED, Funded. (2021 - 2026).
  • Chan, T. (Principal), "Design and construct modular transcriptional repressors to facilitate the development of living diagnostics," sponsored by National Institutes of Health, FED, Funded. (2020 - 2023).
  • Chan, T. (Supporting), Wang, X. (Principal), "Development of Drug Detoxifying Bacteria for Chemotherapy Induced Gut Injury," sponsored by Sanarentero LLC, IND, Funded. (2021 - 2022).
  • Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, Funded. (2019 - 2020).
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Overall
Summative Rating
Challenge and
Engagement Index
Response Rate

out of 5

out of 7
%
of
students responded
  • Overall Summative Rating (median):
    This rating represents the combined responses of students to the four global summative items and is presented to provide an overall index of the class’s quality. Overall summative statements include the following (response options include a Likert scale ranging from 5 = Excellent, 3 = Good, and 1= Very poor):
    • The course as a whole was
    • The course content was
    • The instructor’s contribution to the course was
    • The instructor’s effectiveness in teaching the subject matter was
  • Challenge and Engagement Index:
    This rating combines student responses to several SPOT items relating to how academically challenging students found the course to be and how engaged they were. Challenge and Engagement Index items include the following (response options include a Likert scale ranging from 7 = Much higher, 4 = Average, and 1 = Much lower):
    • Do you expect your grade in this course to be
    • The intellectual challenge presented was
    • The amount of effort you put into this course was
    • The amount of effort to succeed in this course was
    • Your involvement in course (doing assignments, attending classes, etc.) was
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