Tsz Yan Clement Chan

Previous Scheduled Teaching

Published Intellectual Contributions

Journal Article

• Mathis, K., Chan, T., Meckes, B.R. (2024). Controlling Cell Interactions with DNA Directed Assembly. Advanced Healthcare Materials. Wiley. http://dx.doi.org/10.1002/adhm.202402876
• Kinshuk, S., Li, L., Meckes, B.R., Chan, T. (2024). Sequence-Based Protein Design: A Review of Using Statistical Models to Characterize Coevolutionary Traits for Developing Hybrid Proteins as Genetic Sensors. International Journal of Molecular Sciences. 25 8320.
• You, J., Huang, H., Chan, T., Li, L. (2022). Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale. Other. 12 Frontiers Media SA. http://dx.doi.org/10.3389/fneur.2021.779558
• Jiang, X., Dimas, R.P., Chan, C.T., Morcos, F. (2021). Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions. Nature Communications. 12 5592. https://doi.org/10.1038/s41467-021-25851-6
• Dimas, R.P., Jordan, B.R., Jiang, X., Martini, C., Glavy, J.S., Patterson, D.P., Morcos, F., Chan, T. (2019). Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy. Other. 47 (16) 8913-8925. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz666
• Dimas, R.P., Jiang, X., Alberto de la Paz, J., Morcos, F., Chan, T. (2019). Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset. Other. 47 (10) 5449-5463. Oxford University Press (OUP). http://dx.doi.org/10.1093/nar/gkz280
• Lee, J.W., Chan, T., Slomovic, S., Collins, J.J. (2018). Next-generation biocontainment systems for engineered organisms. Nature Chemical Biology. 14 (6) 530-537. https://api.elsevier.com/content/abstract/scopus_id/85047020981
• Chan, T., Lee, J.W., Cameron, D.E., Bashor, C.J., Collins, J.J. (2016). 'Deadman' and 'Passcode' microbial kill switches for bacterial containment. Nature Chemical Biology. 12 (2) 82-86. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nchembio.1979
• Chan, T., Deng, W., Li, F., Demott, M.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2015). Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28 (5) 978-988. https://api.elsevier.com/content/abstract/scopus_id/84929408617
• Dwyer, D.J., Belenky, P.A., Yang, J.H., Cody MacDonald, Martell, J.D., Takahashi, N., Chan, T., Lobritz, M.A., Braff, D., Schwarz, E.G., Ye, J.D., Pati, M., Vercruysse, M., Ralifo, P.S., Allison, K.R., Khalil, A.S., Ting, A.Y., Walker, G.C., Collins, J.J. (2014). Antibiotics induce redox-related physi. Proceedings of the National Academy of Sciences of the United States of America. 111 (20) https://api.elsevier.com/content/abstract/scopus_id/84901059678
• Mandal, D., Köhrer, C., Su, D., Babu, I.R., Chan, T., Liu, Y., Söll, D., Blum, P., Kuwahara, M., Dedon, P.C., Rajbhandary, U.L. (2014). Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Other. 20 (2) 177-188. https://api.elsevier.com/content/abstract/scopus_id/84892739139
• Su, D., Chan, T., Gu, C., Lim, K.S., Chionh, Y.H., McBee, M.E., Russell, B.S., Babu, I.R., Begley, T.J., Dedon, P.C. (2014). Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Other. 9 (4) 828-841. https://api.elsevier.com/content/abstract/scopus_id/84897129376
• Begley, U., Sosa, M.S., Avivar-Valderas, A., Patil, A., Endres, L., Estrada, Y., Chan, T., Su, D., Dedon, P.C., Aguirre-Ghiso, J.A., Begley, T. (2013). A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Other. 5 (3) 366-383. https://api.elsevier.com/content/abstract/scopus_id/84874750617
• Patil, A., Dyavaiah, M., Joseph, F., Rooney, J.P., Chan, T., Dedon, P.C., Begley, T.J. (2012). Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Other. 11 (19) 3656-3665. https://api.elsevier.com/content/abstract/scopus_id/84867259656
• Chan, T., Pang, Y.L., Deng, W., Babu, I.R., Dyavaiah, M., Begley, T.J., Dedon, P.C. (2012). Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3 https://api.elsevier.com/content/abstract/scopus_id/84864828979
• Patil, A., Chan, T., Dyavaiah, M., Rooney, J.P., Dedon, P.C., Begley, T.J. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Other. 9 (7) 990-1001. https://api.elsevier.com/content/abstract/scopus_id/84865298780
• Chan, T., Chionh, Y.H., Ho, C., Lim, K.S., Babu, I.R., Ang, E., Wenwei, L., Alonso, S., Dedon, P.C. (2011). Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis bacille calmette-guérin. Molecules. 16 (6) 5168-5181. https://api.elsevier.com/content/abstract/scopus_id/79959627017
• Chan, T., Dyavaiah, M., DeMott, M.S., Taghizadeh, K., Dedon, P.C., Begley, T.J. (2010). A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Other. 6 (12) 1-9. https://api.elsevier.com/content/abstract/scopus_id/78650683942
• Fu, D., Brophy, J.A., Chan, T., Atmore, K.A., Begley, U., Paules, R.S., Dedon, P.C., Begley, T.J., Samson, L.D. (2010). Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30 (10) 2449-2459. https://api.elsevier.com/content/abstract/scopus_id/77951981033
• Seyedsayamdost, M.R., Chan, T., Mugnaini, V., Stubbe, J., Bennati, M. (2007). PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 129 (51) 15748-15749. https://api.elsevier.com/content/abstract/scopus_id/37549042071
• Seyedsayamdost, M.R., Xie, J., Chan, T., Schultz, P.G., Stubbe, J. (2007). Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: Direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129 (48) 15060-15071. https://api.elsevier.com/content/abstract/scopus_id/36849004028

Contracts, Grants and Sponsored Research

Grant - Research

• Chan, T., "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institute of Health (Award # R35GM142421), Federal, $1525588 Funded. (2021 - 2026).
• Chan, T., "NIH Instrument Supplement R35GM142421-03S1," sponsored by NIH National Institute of General Medical Sciences, Federal, $247975 Funded. (2023 - 2024).
• Singh, R. (Principal), Chan, T. (Principal), Hu, M. (Principal), "Genetic Biocontainment Switch to Improve the Safety of Drug Detoxifying Bacteria in Preventing Chemotherapy-induced Diarrhea," sponsored by National Institutes of Health/National Cancer Institute (R41CA275454), Federal, $399999 Funded. (2023 - 2024).
• Chan, C. (Principal), "DESIGN AND CONSTRUCT MODULAR TRANSCRIPTIONAL REPRESSORS TO FACILITATE THE DEVELOPMENT OF LIVING DIAGNOSTICS," sponsored by National Institutes of Health (Award # 1R15GM135813-01), Federal, $391722 Funded. (2020 - 2023).
• Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, $441684 Funded. (2019 - 2020).
• Chan, T. (Principal), "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors," sponsored by National Institutes of Health, FED, Funded. (2021 - 2026).
• Chan, T. (Principal), "Design and construct modular transcriptional repressors to facilitate the development of living diagnostics," sponsored by National Institutes of Health, FED, Funded. (2020 - 2023).
• Chan, T. (Supporting), Wang, X. (Principal), "Development of Drug Detoxifying Bacteria for Chemotherapy Induced Gut Injury," sponsored by Sanarentero LLC, IND, Funded. (2021 - 2022).
• Chan, C. (Principal), "RUI: Developing modular repressors as in vivo biosensors in various organisms," sponsored by National Science Foundation (Award # 1914538), Federal, Funded. (2019 - 2020).